6,144 research outputs found

    Storia della logica. 2

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    Le parti dovute a Silvio Bozzi riguardano in particolare il Cap.7 e lo sviluppo della Teoria degli Insiemi , della Teoria dei Modelli e in generale dell'indagine metamatematica sino agli anni 60 cercando di individuarne gli snodi fondamentale e le prospettive aperte

    Storia della logica. 1

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    Nelle parti opera esclusiva di Silvio Bozzi (la divisione è indicata nell'introduzione) si affrontano temi diversi riguardanti lo sviluppo della Logica da Boole alla Prima Guerra Mondiale. Sottolineo in particolare il capitolo dedicato al passaggio dall'Algebra della Logica alla Logica Algebrica (Cap.2,7 - 7.3.)

    Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine

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    Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Several lines of evidence demonstrate that inflammatory processes within the brain parenchyma contribute to recurrence and precipitation of seizures. In both epileptic patients and animal models, seizures upregulate inflammatory mediators, which in turn may enhance brain excitability. We recently showed that the C-C motif ligand 2 (CCL2) chemokine (also known as monocyte chemoattractant protein-1 [MCP-1]) mediates the seizure-promoting effects of inflammation. Systemic inflammatory challenge in chronically epileptic mice markedly enhanced seizure frequency and upregulated CCL2 expression in the brain. Selective pharmacological blockade of CCL2 synthesis or C-C chemokine receptor type 2 (CCR2) significantly suppressed inflammation-induced seizures. These results have important implications for the development of novel anticonvulsant therapies: drugs interfering with CCL2 signaling are used clinically for several human disorders and might be redirected for use in pharmacoresistant epilepsy. Here we review the role of CCL2/CCR2 signaling in linking systemic inflammation with seizure susceptibility and discuss some open questions that arise from our recent studies

    Microwave components realized by additive manufacturing techniques

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    This paper presents an overview of the use of additive manufacturing (AM) technologies for the implementation of microwave components. Two major technological solutions, based on the AM of plastic materials, are discussed: in the former case, the AM plastic is used as a dielectric material that constitutes the component. Conversely, in the latter case, the plastic material is a mere support of the metallization, thus avoiding the contact of the AM plastic with the electromagnetic field and reducing losses. Several examples are illustrated and discussed, to highlight benefits and limitations of AM techniques in the current scenario of microwave applications

    Safety of escitalopram in pregnancy: a case series

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    Cesario Bellantuono, Francesca Bozzi, Laura Orsolini Psychiatric Unit and DEGRA Center, United Hospital and Academic Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy Background: The aim of this paper is to report maternal and neonatal outcomes in pregnant women treated with escitalopram during pregnancy and breastfeeding. Methods: Women enrolled in the DEGRA Database at the Clinic of Affective Disorders in Pregnancy and Postpartum in Italy, treated during pregnancy with escitalopram and followed up throughout pregnancy, were included in this study. All patients provided written informed consent and the study was approved by the local ethics committee. Psychiatric diagnoses were assessed using the Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition) Axis I Disorders and symptoms were assessed using the Hamilton Rating Scale for Depression (17 items) and Hamilton Rating Scale for Anxiety (14 items). Clinical and sociodemographic characteristics as well as maternal and neonatal outcomes were recorded. Results: The case histories of seven pregnant women treated for depression and/or anxiety disorders with escitalopram were reported. Four women were also treated with benzodiazepines. All pregnancies were full-term and all newborns had normal Apgar scores. There were no major malformations or miscarriages following exposure to escitalopram. Mild withdrawal syndrome was reported only in a newborn who was also exposed to a benzodiazepine. Two infants exposed to escitalopram during breastfeeding did not show any health problems. Conclusion: Our experience with use of escitalopram in pregnant women did not reveal any maternal or neonatal concerns. However, considering the few cases analyzed and the paucity of published literature, no conclusions can be drawn on its safety profile in pregnancy and breastfeeding. Keywords: escitalopram, pregnancy, breastfeeding, major malformations, perinatal complication

    Osservazioni sull’indipendenza dell’esperienza immediata: da Frege alla «fenomenologia sperimentale» di Paolo Bozzi

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    Paolo Bozzi developed his «experimental phenomenology» from the Gestalt psychology tradition, particularly from Gaetano Kanizsa’s method. The distinction between «phenomenal description» and «causal explanation» of the «perception» springs up from the analysis of Bozzi’s «S-D psychophysical scheme». What Frege, who was well-known by Bozzi, deals with in paragraph 71 of The Thought theoretically mirrors what is outlined in the Scheme and could also be intended as its source. The juxtaposition between a «science of observable things» or «experimental phenomenology» – conceived as a science which is autonomous from what happens in the brain – and logics, which is set up autonomously from the thinking processes, is a programmatic element that is openly indicated by the author. Frege’s anti-psychologism and realism are both widely shared by Bozzi. The realism and the «naïve physics» Bozzi was a pioneer of lie at the basis of the so-called «New Realism». The following essay aims to localize and highlight some theoretical implications – up to their phenomenological origins – which can be detected particularly in paragraph 71 of The Thought. The present work tries to sketch out the boundaries and the autonomy of the «first person» perceptive experience and to define the scientific explanation that we can give of it. The distinction between science and experience, and the autonomy of experience from science and of the immediate experience of the content of consciousness from neuroscience, entail the impossibility of a naturalization of the phenomenological experience. In the examples taken from Frege can be found a theoretical bridge which connects the Gestalt perceptological tradition, Wittgenstein’s investigations of the philosophy of psychology, and the so called «New Realism».</p
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