433 research outputs found
Un frammento inedito di Leon Battista Alberti sul fuoco
No full textThe author publishes the initial fragment of an unknown treatise by Leon Battista Alberti on the casting of statues written around 1455 and preserved in cod. Ottob. lat. 1870. The fragment contains a discussion on the nature of light and the element of fire
Filosofia, scienza e ricette. Note su una miscellanea alchemico-farmaceutica (ms Modena, Biblioteca Estense, Campori, App. 186: Alpha P 4 14
No full textsi pubblicano delle ricette alchemiche in siciliano antico dei primi del XIII secolo provenienti dall'ambiente "dei musulmani di Lucera
Effects of early angiotensin-converting enzyme inhibition in patients with non-ST-elevation acute myocardial infarction.
No full textBACKGROUND:
No data are available on the clinical efficacy of the early administration (<24 hours from onset of chest pain) of angiotensin-converting enzyme inhibitors in non-thrombolysed patients with non-ST-elevation myocardial infarction (NSTEMI). We have addressed this issue in a subgroup of NSTEMI patients enrolled in the SMILE trial.
METHODS:
Of the overall population of 1556 patients, 526 (33.8%) had an anterior wall NSTEMI, defined as an ST elevation <1 mm or an ST depression in at least two contiguous precordial leads with or without new abnormal Q waves. No patient of the SMILE Study received thrombolytic therapy or was reperfused. Patients were randomized, double-blind, to zofenopril (n = 253) or placebo (n = 273) for 6 weeks. The primary end point was the effect of treatment on the 6-week combined occurrence of death and severe congestive heart failure (CHF). Secondary end points included the evaluation of the 6-week rate of severe CHF as well as the 1-year mortality rate.
RESULTS:
After 6 weeks of treatment, zofenopril significantly reduced both the incidence of the primary end point (risk reduction 65%, 95% CI 20-80, 2P = .003) and the 6-week incidence of severe CHF (84%, 95% CI 33-97, 2P = .006) in NSTEMI patients. One-year mortality was also significantly reduced by zofenopril treatment (43%, 95% CI 14-57, 2P = .036).
CONCLUSIONS:
Results of this post hoc analysis of the SMILE Study strongly suggest the benefit of the early administration of zofenopril even in patients with an anterior wall NSTEMI
Long-term clinical experience with zofenopril.
No full textAngiotensin-converting enzyme inhibitors are extensively used to improve clinical outcome of patients with several cardiovascular diseases. Zofenopril proved to be very effective in patients with coronary artery disease and myocardial infarction, thanks to its unique effective mechanism of action for improving blood pressure control, left ventricular function and myocardial ischemia burden, as well as angiotensin-converting enzyme inhibition. The SMILE project involved more than 3500 patients with coronary artery disease and demonstrated that zofenopril treatment may reduce mortality and morbidity in patients with myocardial infarction, also when combined with acetyl salicylic acid and to a greater extent than lisinopril and ramipril. In addition, the results of the SMILE-ISCHEMIA study have demonstrated an interesting anti-ischemic effect of zofenopril, and these properties largely contribute to the overall clinical benefit of the drug. The effects of zofenopril on blood pressure control and cardiovascular protection clearly support its primary role for prevention and treatment of cardiovascular disease
Positano in prosa
No full textGli autorevoli contributi, introdotti da un'ampia e articolata introduzione del curatore del volume, mirano a suggerire un'immagine fortemente letteraria della Costiera amalfitana e di una delle sue perle più preziose
Uniqueness in the inverse conductivity problem for thin imperfections weakly or strongly conducting
No full textOn the Effectiveness of Manual and Automatic Unit Test Generation
No full textThe importance of testing has recently seen a significant
growth, thanks to its benefits to software design (e.g. think
of T.D.D.), implementation and maintenance support. As
a consequence of this, nowadays it is quite common to in-
troduce a test suite into an existing system, which was not
designed for it. The software engineer must then decide
whether using tools which automatically generate unit tests
(test suites necessary foundations) and how.
This paper tries to deal with the issue of choosing the
best approach. We will describe how different generation
techniques (both manual and automatic) have been applied
to a real case study. We will compare achieved results us-
ing several metrics in order to identify different approaches
benefits and shortcomings. We will conclude showing the
measure how the adoption of tools for automatic test cre-
ation can shift the trade-off between time and quality
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