4,664 research outputs found
Deborah Harkness Book Talk and Signing
No full textThe Z. Smith Reynolds Library Lecture Series presents a talk and book signing by Deborah Harkness, author of the bestselling novels A Discovery of Witches and Shadow of Night. Deborah is a featured author at the 9th annual Bookmarks Festival of Books. Her Wake Forest appearance is co-sponsored by Bookmarks and ZSR Library as part of the Bookmarks Authors in Schools program
The role of calcium and actions of calcium antagonists in human colonic smooth muscle
No full textMacroscopically normal human colon was obtained from patients undergoing colonic resection. In muscle strips suspended under tension, KCl (20-120mM) induced biphasic activity, with peak phasic followed by sustained tonic components. Contracture was abolished in Ca2+-free/EGTA Krebs solution. Nitrendipine, verapamil and diltiazem (10-10-10-6M) caused concentration-dependent inhibition, with no significant discrimination between phasic and tonic KCl responses. Calmodulin antagonists, TMB8 and W7 (10-5-10-3M), also non-selectively suppressed KCl contracture. ACh rapidly stimulated human colonic muscle, inducing recurrent contraction/relaxation spiking over a tonic contraction. Ca2+ antagonists (5x10-6-10-5M) selectively abolished spike activity without reducing sustained tone. BAY K 8644 (10-8-10-6M) caused slow-developing contraction/relaxation spiking, but the effect was abolished at > 5 x 10-6M. Nitrendipine, verapamil and diltiazem (10-7-10-5M) inhibited BAY K 8644 contracture, indicating closely-linked drug receptor sites. [3H]-nitrendipine binding to human colonic membrane fractions was saturable, reversible, and of high affinity. Scatchard analysis of saturation studies gave an average Kd ofg 0.98nM, and Bmax of 161.5fmoles/mg protein, assuming a single dihydropyridine binding site. [3H]-nitrendipine binding, with Ki values of 1.82 x 10-13, 8.59 x 10-13 and 1.40 x 10-8M, respectively. Verapamil showed incomplete displacement and diltiazem caused specific binding enhancement, suggesting allosteric receptor interaction. 45Ca efflux was studied in 20mg muscle pieces, preloaded in 45Ca-Krebs solution (10μCi/ml). Perfusion with non-isotopic buffer (1.0ml/min) resulted in biphasic efflux, with fast extracellular Ca^2+ washout followed by slower removal of intracellular Ca^2+ stores. 80mM KCl stimulated slow ^45Ca efflux, with the response abolished in Ca^2+ free/EGTA or 20mMLa^3+ Krebs solution. Pretreatment with 10^-6M nitrendipine also inhibited KCl-stimulated efflux. Similarly ^45Ca influx, by the lanthanum method, could be stimulated by 60mM KCl and was significantly inhibited by 10^-6M nitrendipine (p < 0.05). Functionally intact, viable smooth muscle cells were successfully isolated from human colonic muscularis by collagenase (1.5mg/ml), hyaluronidase (0.75mg/ml) digestion. Muscle cell yield averaged 1.97 x 10^-5 cells/g wet weight tissue (viability, > 95% purity, 63%). Preliminary measurement of intracellular calcium transients was achieved in Fura-2 loaded, isolated muscle cells, confirming their functional integrity. It is concluded that activator calcium mobilisation, from both extracellular and intracellular sources, is central to the contractile response of human colonic muscle. The contribution of each depends upon the stimulant and phase of mechanical activity studied. Extracellular calcium influx is predominantly via voltage-dependent calcium channels.</p
Standardizing an Organizational Approach to CARF Survey Preparation: A Quality Improvement Project
No full textStandardizing an Organizational Approach to CARF Survey Preparation is a design-based research project that synthesizes the existing knowledge of four interdisciplinary communities of practice to create an effective and efficient program that is process-driven rather than person-dependent. As a quality improvement project, its final product consists of instruments that facilitate ongoing readiness for accreditation preparation and serve as the basis for better practices in the organization under study.ProQuest Traditional Publishing Optio
Medication Use in Pregnant Women with Chronic Medical Conditions
No full textDr. Deborah Zeitlin addresses medication options for pregnant women with chronic conditions such as: hypertension, asthma, diabetes, and depression. Risks of medication use to the fetus are addressed
Author Deborah Heffernan of Bridgton describes how secret plans to have a Queen
No full textAuthor Deborah Heffernan of Bridgton describes how secret plans to have a Queen Anne bonnet-top high boy built for her husband Jack Heffernan turned into a community affair, while yet remaining a secret. The actual design and construction of the high boy fell on Bob Dunning, with the help cabinetmaker Greg Marston. Others involved on the project included Mary and Don Johnson and their sons Tom and Eric. With descriptive details of elements included in the highboy
Lecture: Author Deborah Eisenberg reads from her story, "Some Other, Better Otto" Nov. 2 at Vanderbilt University
No full textIncludes descriptive metadata provided by producer in MP3 file: "Listen to author Deborah Eisenberg read from her story 'Some Other, Better Otto' from her collection Twilight of the Superheroes on Nov. 2 in Buttrick Hall. Introducing Eisenberg is Nancy Reisman, assistant professor of English.
Workplace Theft: A Proposed Model and Research Agenda
No full textLucy A. McClurg is an associate professor in the W. T. Beebe Institute of Personnel and Employment Relations, Georgia State University, Atlanta, Georgia 30303-4014
Deborah S. Butler is an associate professor in the Department of Management, Robinson College of Business. Georgia State University, Atlanta, Georgia 30303-4014
Feminismo (2019) de Deborah Cameron
No full textFeminism is a small compilation of the debates that have run through the movement, especially in the West. Narrated in a simple and entertaining style, based on compilations of different themes, studies and references, it addresses the main questions of feminism and exposes the answers that have been provided from different positions.
TECHNICAL SHEET OF THE BOOK
Title: Feminism. Author: Cameron, Deborah. Translation: Tercero, Maria Enguix. Publisher: Alianza Editorial. Language: Spanish. Pages: 176. Year: 2019. Place: Madrid. EBOOK ISBN: 978-84-9181-541-9. Original title: Feminism. 1st edition in English, 2018, Great Britain. Profile Books LTD.Feminismo es una pequeña compilación de los debates que han atravesado al movimiento, especialmente en occidente. Narrado en un estilo simple y llevadero, en base a recopilaciones de distintos temas, estudios y referentes, va abordando los principales interrogantes del feminismo y exponiendo las respuestas que se han brindado desde diferentes posiciones.
FICHA TÉCNICA DE LA OBRA
Título: Feminismo. Autora: Cameron, Deborah. Traducción: Tercero, María Enguix. Editorial: Alianza Editorial. Idioma: Castellano. Páginas: 176. Año: 2019. Lugar: Madrid. ISBN ebook: 978-84-9181-541-9. Título original: Feminism. 1° edición en inglés, 2018, Gran Bretaña. Profile Books LTD
Deborah Cheetham \u27It’s not over till the Black Lady Sings\u27.
No full textThis year’s annual Nulungu lecture at the University of Notre Dame Australia’s Broome Campus will be delivered by Deborah Cheetham, Indigenous Soprano, actor and author of the internationally acclaimed play, White Baptist Abba Fan. She is a graduate of the NSW Conservatorium of Music and Julliard School of Music.
Since her international debut in 1997 Ms Cheetham has performed in the theatres and concert halls of United States, Europe, the United Kingdom, New Zealand and throughout Australia. At the Sydney Olympics in 2000, Ms Cheetham performed her original composition, Dali Mana Gamarada.
During the 2001 Centenary of Federation celebrations Ms Cheetham performed in several major events including the January 1st Concert in Sydney’s Centennial Park when she appeared as a soloist and speaker. She performed with Argentine tenor, Jose Cura at the opening ceremony of the Rugby World Cup in 2003. This was broadcast to a worldwide audience of more than one billion. In 2005, Deborah added to her list of international credit engagements in Paris, including performances at the Australian Embassy and the La Cigale in the Marais
In 2006 Deborah was a recipient of the Australia Council, Aboriginal and Torres Strait Islander Arts fellowship. The fellowship enabled Deborah to write, direct and produce a 21st century Australian opera, Pecan Summer. The work created opportunities and demonstrated the talents of Indigenous singers and musicians, actors, writers and technicians.
On 22nd February this year Deborah performed the national anthem at the memorial service for the victims of the Black Saturday bushfires. Of the service Deborah said , ‘Joined by a massed choir of over 500 voices I was honoured to pay my respect to the victims and survivors of these terrible fires by singing Advance Australia Fair.’
Deborah will be delivering the Nulungu Lecture at the Broome Campus of The University of Notre Dame, 88 Guy Street, Broome, on Thursday 20 August at 5.00pm. The Nulungu Reconciliation Lecture is to be an annual event on the Broome Campus where key speakers will be invited to address issues of Reconciliation that shape contemporary Aboriginal and Australian thought and experience. The title of Deborah’s lecture is It’s not over till the Black Lady Sings
Pulmonary Embolism as an Adverse Drug Event of Intravenous Immunoglobulin Therapy
No full textTO THE EDITOR: Intravenous immunoglobulin (IVIG) therapy has gained popularity for the treatment of neuromuscular diseases (i.e., myasthenia gravis, inflammatory myopathy, chronic inflammatory demyelinating polyneuropathy), although adverse events are associated with high-dose IVIG infusions.1,2 Common adverse reactions to IVIG therapy are anxiety, headache, fever, chills, chest pain, dyspnea, nausea, and abdominal pain.3 More serious adverse events include anaphylaxis, hemolytic anemia, hepatitis C, and thrombosis.3 Studies have shown documented effects of IVIG on blood rheology. It increases plasma viscosity in a dose-related response and may also activate platelets.2–4 High-dose IVIG therapy is approximately 24–54 g/d.
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