1,720,983 research outputs found
New glucocorticoids on the horizon: Repress, don't activate!
No full textGlucocorticoids are highly effective drugs; their immunosuppressive and antiinflammatory actions are used in the treatment of many rheumatic and other inflammatory diseases. However, their use is sometimes considerably limited by numerous adverse reactions. For this reason, great efforts have been made in recent years to develop innovative glucocorticoids or glucocorticoid receptor ligands that have improved therapeutic effect/adverse reaction ratio. We summarize the position and critically discuss the following products that are currently under development: (1) selective glucocorticoid receptor agonists (SEGRA or dissociating glucocorticoids); (2) nitrosteroids; and (3) long-circulating liposomal glucocorticoids. Finally, we describe the state of research on membrane-bound glucocorticoid receptors as possible further targets for specific glucocorticoid actions
New glucocorticoids on the horizon: Repress, don't activate!
No full textGlucocorticoids are highly effective drugs; their immunosuppressive and antiinflammatory actions are used in the treatment of many rheumatic and other inflammatory diseases. However, their use is sometimes considerably limited by numerous adverse reactions. For this reason, great efforts have been made in recent years to develop innovative glucocorticoids or glucocorticoid receptor ligands that have improved therapeutic effect/adverse reaction ratio. We summarize the position and critically discuss the following products that are currently under development: (1) selective glucocorticoid receptor agonists (SEGRA or dissociating glucocorticoids); (2) nitrosteroids; and (3) long-circulating liposomal glucocorticoids. Finally, we describe the state of research on membrane-bound glucocorticoid receptors as possible further targets for specific glucocorticoid actions
Comparison of contrast-enhanced ulthasunography (CE-US) and MR-imaging (CE-MRI) in monitoring the efficacy of a bradykinin receptor-2 antagonist in painful knee osteoarthritis (OA)
No full textComparison of contrast-enhanced ulthasunography (CE-US) and MR-imaging (CE-MRI) in monitoring the efficacy of a bradykinin receptor-2 antagonist in painful knee osteoarthritis (OA)
No full textSeven year follow-up imaging study comparing conventional radiography and ultrasound in rheumatoid arthritis finger joints
No full textComparison of the efficacy of contrast-enhanced ultrasonography and magnetic resonance imaging in detecting synovial process in patients with knee osteoarthritis compared to healthy subjects.
No full textSignificance of B-mode, power Doppler- and echo-intensifier sonography in RA patients under anti-TNF alpha treatment
No full textComparison of the efficacy of contrast-enhanced ultrasonography and magnetic resonance imaging in detecting synovial process in patients with knee osteoarthritis compared to healthy subjects.
No full textSignificance of B-mode, power Doppler- and echo-intensifier sonography in RA patients under anti-TNF alpha treatment
No full textDiagnostic quality and scoring of synovitis, tenosynovitis and erosions in low-field MRI of patients with rheumatoid arthritis: a comparison with conventional MRI
No full textObjective: To compare dedicated low- field MRI ( lfMRI) with conventional MRI ( cMRI) in the detection and scoring of synovitis, tenosynovitis and erosions in patients with rheumatoid arthritis. Patients and methods: The wrist and finger joints of 17 patients with rheumatoid arthritis ( median ( range) disease duration 8 years ( 7 - 12); Disease Activity Score 3.3 ( 2.6 - 4.5)) were examined by 0.2 T lfMRI and 1.5 TcMRI. The protocols comprised coronal spin- echo and three- dimensional gradient- echo sequences before and after contrast medium administration. Synovitis of the metacarpophalangeal and proximal interphalangeal joints 2 - 5 and the wrist joints was scored according to Outcome Measures in Rheumatology recommendations. Tenosynovitis and erosions were scored using 4- point and 6- point scales, respectively. The results were analysed by calculating k values and performing McNemar's test intra- individually on a joint- byjoint basis. Results: Agreement between the two MRI techniques was good to excellent for synovitis and erosions, and moderate for tenosynovitis. Of the 306 joints evaluated, 245 and 200 joints showed synovitis in lfMRI and cMRI, respectively. Scoring of synovitis of the finger joints yielded k values from 0.69 to 0.94. Of the 68 flexor tendons evaluated, tenosynovitis was diagnosed by lfMRI in 24 and by cMRI in 33 instances. Of the 391 bones evaluated, 154 and 139 showed erosions in lfMRI and cMRI, respectively. k values for erosion scores were between 0.65 and 1. Conclusion: Dedicated, lfMRI shows high agreement with cMRI in diagnosing and scoring synovitis, tenosynovitis and erosions in rheumatoid arthritis when using standardised scoring systems
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