101,575 research outputs found
A review of the Upper Triassic source rocks of Italy.
No full textThis is a description of the hydrocarbon potential of Upper Triassic rocks from Italy
Cyclic sedimentation in the Southern Alpine Rhaetic: the importance of climate and eustasy in controlling platform‐basin interactions
No full textUppermost Triassic (Rhaetic) facies, as developed in the Southern Alpine region of Northern Italy, were deposited in a rapidly subsiding, fault‐dissected trough (the Lombardy Basin) bounded by carbonate platforms. The main part of the Rhaetic succession consists of 10‐m‐scale asymmetric cycles, each divided into three parts: a lower shale portion; a central rhythmic portion consisting of repeated marl‐limestone couplets, the limestone parts of which thicken upward; and an upper, wholly carbonate unit. A study of the diagenetic history of the series demonstrates that both the major asymmetric cyclicity and the limestone‐marl couplets of the central rhythmic member (together constituting a ‘compound’ cyclic form) are fundamentally depositional in nature. It is suggested that this compound cyclicity resulted from the superposition of a low‐frequency (approximately 100 000‐year periodicity) asymmetric carbonate mud signal with a higher‐frequency terrigenous mud signal. Field, petrographic, and geochemical investigations suggest that the basinal carbonate is predominantly allochthonous in origin, having been derived as relatively pure aragonitic mud from adjacent carbonate platforms. It is postulated that the asymmetric carbonate signal was linked to the ecological effects of eustatic fluctuation on platform carbonate systems. Repeated subaerial exposure of subtidal muds in shallow areas indicates that such sea‐level variations occurred. A model is presented in which the basinward export of carbonate was negligible in the deepening phase, increased to a maximum during shallowing and was finally halted by the emergence of large platform flats. In contrast, the higher frequency terrigenous mud signal of the basin is thought to have been climatically modulated; fluctuations of a shorter period than those predicted by the Milankovitch theory affected hinterland precipitation and runoff. Particularly rapid subsidence and high depositional rates may have allowed the preservation of this signal. Copyright © 1990, Wiley Blackwell. All rights reserve
Breast carcinoma cell lysate-pulsed dendritic cells cross-prime MUC1 specific cytotoxic T-cells identified by peptide-MHC-class-I tetramers
No full textBohnenkamp H, Coleman J, Burchell J, Taylor-Papadimitriou J, Noll T. Breast carcinoma cell lysate-pulsed dendritic cells cross-prime MUC1 specific cytotoxic T-cells identified by peptide-MHC-class-I tetramers. Cellular Immunology. 2004;231(1-2):112-125
Flexicurity as a moderator of the relationship between job insecurity and psychological well-being
Get PDFFlexicurity has been heralded as the solution to simultaneously maintain the well-being of employees through employment security while allowing employers to benefit from flexibility. This paper examines one of the claimed benefits that countries with flexicurity policies will reduce the stress on employees who experience job insecurity. More specifically, it is argued that more generous unemployment benefits along with active labour market policies to facilitate rapid re-employment reduces the anxiety associated with insecurity. Analyses of two international data sets found little evidence for this moderation of the link between insecurity and well-being in countries that are assumed to be exemplars of flexicurity. The economic rationality behind these claims is questioned, and a psychological approach to job insecurity is suggested as an alternative
Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells
No full textBohnenkamp H, Burchell J, Taylor-Papadimitriou J, Noll T. Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells. Journal of Immunological Methods. 2005;294(1-2):67-80
Laboratory Studies of Hypervelocity Impacts on Solar System Analogues
Get PDFImpact cratering and asteroid collisions are major processes throughout the Solar System. Although previous collision-related impact investigations exist (Flynn et al. 2015, Holsapple et al. 2002 and Burchell et al. 1998 are good examples), in the works covering this broad range of investigation, the targets are non-rotating (for the purposes of catastrophic disruption) and different temperature conditions are not considered (for impact cratering). Accordingly, I present experimental processes and data, regarding hypervelocity impact experiments into analogues of (1) rotating asteroids and (2) temperature dependant terrestrial planetary rock.
During the course of this work, it was necessary to develop new apparatus and new experimental techniques such as three separate target holders to aid in both catastrophic disruption and heated impact projects, a 3-dimensional model analysis of craters and a completely new, statistically robust, technique to determine a complete crater profile called the KDM method where KDM is Kinnear-Deller-Morris.
The main result from this work showed that during an asteroid impact collision where the asteroid is not rotating, the impact energy density for catastrophic disruption is Q*static = 1442 ± 90 J kg-1. However, when the target asteroid was rotating, the condition Q*rotation = 1097 ± 296 J kg-1. The mean value of Q* had thus reduced, but the spread in the data on individual experiments was larger. This leads to two conclusions. The mean value for Q*, based on measurements of many impacts, falls, due to the internal forces acting in the body which are associated with the rotation. This energy term reduction means that the amount of energy to instigate catastrophic disruption is lower and that a rotating asteroid is effectively weaker upon impact than a stationary asteroid. However, the spread in the results indicates that this is not a uniform process, and an individual result for Q* for a rotating or spinning target may be spread over a large range. For the temperature related impacts, as the targets were heated to approximately 1000 K, the target rocks showed an impact dependence more similar to a plastic phase-state than to solidus, due to being held close to temperatures associated with semi-plastic phases. Basalt impact craters displayed this relationship greatest with crater sizes becoming smaller at the higher temperature ranges but larger in the colder brittle solidus temperatures, partly explained in experiments by increased spallation
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Immunodetection of the expression of microsomal proteins encoded by the glucose-6-phosphate transporter gene
No full textGlucose 6-phosphate transport has been well characterized in liver microsomes. The transport is required for the functioning of the glucose-6-phosphatase enzyme that is situated in the lumen of the hepatic endoplasmic reticulum. The genetic deficiency of the glucose 6-phosphate transport activity causes a severe metabolic disease termed type 1b glycogen storage disease. The cDNA encoding a liver transporter for glucose 6-phosphate was cloned and was found to be mutated in patients suffering from glycogen storage disease 1b. While related mRNAs have been described in liver and other tissues, the encoded protein(s) has not been immunologically characterized yet. In the present study, we report (using antibodies against three different peptides of the predicted amino acid sequence) that a major protein encoded by the glucose 6-phosphate transporter gene is expressed in the endoplasmic reticulum membranes of rat and human liver. The protein has an apparent molecular mass of approx. 33 kDa using SDS/PAGE, but several lines of evidence indicate that its real molecular mass is 46 kDa, as expected. The glucose 6-phosphate transporter protein was also immunodetected in kidney microsomes, but not in microsomes derived from human fibrocytes, rat spleen and lung, and a variety of cell lines. Moreover, little or no expression of the glucose 6-phosphate transporter protein was found in liver microsomes obtained from three glycogen storage disease 1b patients, even bearing mutations that do not directly interfere with protein translation, which can be explained by a (proteasome-mediated) degradation of the mutated transporter
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Get PDFIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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