2,244 research outputs found
Deathly Drool: Evolutionary and Ecological Basis of Septic Bacteria in Komodo Dragon Mouths
No full textJ. J. Bull is with UT Austin; Marvin Whiteley is with UT Austin; Tim S. Jessop is with University of Melbourne.Komodo dragons, the world's largest lizard, dispatch their large ungulate prey by biting and tearing flesh. If a prey escapes, oral bacteria inoculated into the wound reputedly induce a sepsis that augments later prey capture by the same or other lizards. However, the ecological and evolutionary basis of sepsis in Komodo prey acquisition is controversial. Two models have been proposed. The “bacteria as venom” model postulates that the oral flora directly benefits the lizard in prey capture irrespective of any benefit to the bacteria. The “passive acquisition” model is that the oral flora of lizards reflects the bacteria found in carrion and sick prey, with no relevance to the ability to induce sepsis in subsequent prey. A third model is proposed and analyzed here, the “lizard-lizard epidemic” model. In this model, bacteria are spread indirectly from one lizard mouth to another. Prey escaping an initial attack act as vectors in infecting new lizards. This model requires specific life history characteristics and ways to refute the model based on these characteristics are proposed and tested. Dragon life histories (some details of which are reported here) prove remarkably consistent with the model, especially that multiple, unrelated lizards feed communally on large carcasses and that escaping, wounded prey are ultimately fed on by other lizards. The identities and evolutionary histories of bacteria in the oral flora may yield the most useful additional insights for further testing the epidemic model and can now be obtained with new technologies.Supported by National Institutes of Health (NIH) GM57756 and the University of Texas Miescher Regents Professorship to JJB and NIH AI075068 to MW. TSJ was supported by a Conservation Research Fellowship from the Zoological Society of San Diego. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o
3D development of detachment faulting during continental breakup
No full textThe developing asymmetry of rifting and continental breakup to form rifted margins has been much debated, as has the formation, mechanics and role of extensional detachments. Bespoke 3D seismic reflection data across the Galicia margin, west of Spain, image in unprecedented detail an asymmetric detachment (the S reflector). Mapping S in 3D reveals its surface is corrugated, proving that the overlying crustal blocks slipped on S surface during the rifting. Crucially, the 3D data show that the corrugations on S perfectly match the corrugations observed on the present-day block-bounding faults, demonstrating that S is a composite surface, comprising the juxtaposed rotated roots of block-bounding faults as in a rolling hinge system with each new fault propagation moving rifting oceanward; changes in the orientation of the corrugations record the same oceanward migration. However, in contrast to previous rolling hinge models, the slip of the crustal blocks on S occurred at angles as low as ∼20°, requiring that S was unusually weak, consistent with the hydration of the underlying mantle by seawater ingress following the embrittlement of the entire crust. As the crust only becomes entirely brittle once thinned to ∼10 km, the asymmetric S detachment and the hyper-extension of the continental crust only developed late in the rifting process, which is consistent with the observed development of asymmetry between conjugate magma poor margin pairs. The 3D volume allows analysis of the heaves and along strike architecture of the normal faults, whose planes laterally die or spatially link together, implying overlaps in faults activity during hyper-extension. Our results thus reveal for the first time the 3D mechanics and timing of detachment faulting growth, the relationship between the detachment and the network of block-bounding faults above it and the key processes controlling the asymmetrical development of conjugate rifted margins
Evaluating Citebase, an open access Web-based citation-ranked search and impact discovery service
No full textCitebase is a new citation-ranked search and impact discovery service that measures citations of scholarly research papers which are openly accessible on the Web, i.e. papers that are assessable continuously online. Other services, such as ResearchIndex, have emerged in recent years to offer citation indexing of Web research papers. In the first detailed user evaluation of an open access Web citation indexing service, Citebase has been evaluated by nearly 200 users from different backgrounds. The paper details the procedures used in the evaluation, and analyses the results of this study, which took place between June and October 2002. It was found that within the scope of its primary components, the search interface and services available from its rich bibliographic records, Citebase can be used simply and reliably for the purpose intended, and that it compares favourably with other bibliographic services. It is shown tasks can be accomplished efficiently with Citebase regardless of the background of the user. More data need to be collected and the process refined before it is as reliable for measuring citation impact of indexed papers. Better explanations and guidance are required for first-time users. Coverage is seen as a limiting factor, even though Citebase indexes over 200,000 papers from arXiv. Non-physicists were frustrated at the lack of papers from other sciences. The principle of citation searching of open access archives has thus been demonstrated and need not be restricted to current users. Since the evaluation, Citebase has become a featured service of the ArXiv physics eprint archives
Catholic Comments Podcast.
No full textAuthor Tim Rinaldi discusses his mission work in Honduras and how it changed his life and perspective
Body mass index cut offs to define thinness in children and adolescents: international survey
No full textOBJECTIVE: To determine cut offs to define thinness in children and adolescents, based on body mass index at age 18 years.DESIGN: International survey of six large nationally representative cross sectional studies on growth. SETTING: Brazil, Great Britain, Hong Kong, the Netherlands, Singapore, and the United States. SUBJECTS: 97 876 males and 94 851 females from birth to 25 years. MAIN OUTCOME MEASURE: Body mass index (BMI, weight/height(2)). RESULTS: The World Health Organization defines grade 2 thinness in adults as BMI <17. This same cut off, applied to the six datasets at age 18 years, gave mean BMI close to a z score of -2 and 80% of the median. Thus it matches existing criteria for wasting in children based on weight for height. For each dataset, centile curves were drawn to pass through the cut off of BMI 17 at 18 years. The resulting curves were averaged to provide age and sex specific cut-off points from 2-18 years. Similar cut offs were derived based on BMI 16 and 18.5 at 18 years, together providing definitions of thinness grades 1, 2, and 3 in children and adolescents consistent with the WHO adult definitions. CONCLUSIONS: The proposed cut-off points should help to provide internationally comparable prevalence rates of thinness in children and adolescent
A low-angle detachment fault revealed: three-dimensional images of the S-reflector fault zone along the Galicia passive margin
No full textA new 3-D seismic reflection volume over the Galicia margin continent–ocean transition zone provides an unprecedented view of the prominent S-reflector detachment fault that underlies the outer part of the margin. This volume images the fault's structure from breakaway to termination. The filtered time-structure map of the S-reflector shows coherent corrugations parallel to the expected paleo-extension directions with an average azimuth of 107°. These corrugations maintain their orientations, wavelengths and amplitudes where overlying faults sole into the S-reflector, suggesting that the parts of the detachment fault containing multiple crustal blocks may have slipped as discrete units during its late stages. Another interface above the S-reflector, here named S′, is identified and interpreted as the upper boundary of the fault zone associated with the detachment fault. This layer, named the S-interval, thickens by tens of meters from SE to NW in the direction of transport. Localized thick accumulations also occur near overlying fault intersections, suggesting either non-uniform fault rock production, or redistribution of fault rock during slip. These observations have important implications for understanding how detachment faults form and evolve over time. 3-D seismic reflection imaging has enabled unique insights into fault slip history, fault rock production and redistribution
Accepting Optimally in Automated Negotiation with Incomplete Information (abstract)
No full textIntelligent SystemsElectrical Engineering, Mathematics and Computer Scienc
What to bid and when to stop
No full textNegotiation is an important activity in human society, and is studied by various disciplines, ranging from economics and game theory, to electronic commerce, social psychology, and artificial intelligence. Traditionally, negotiation is a necessary, but also time-consuming and expensive activity. Therefore, in the last decades there has been a large interest in the automation of negotiation, for example in the setting of e-commerce. This interest is fueled by the promise of automated agents eventually being able to negotiate on behalf of human negotiators.Every year, automated negotiation agents are improving in various ways, and there is now a large body of negotiation strategies available, all with their unique strengths and weaknesses. For example, some agents are able to predict the opponent's preferences very well, while others focus more on having a sophisticated bidding strategy. The problem however, is that there is little incremental improvement in agent design, as the agents are tested in varying negotiation settings, using a diverse set of performance measures. This makes it very difficult to meaningfully compare the agents, let alone their underlying techniques. As a result, we lack a reliable way to pinpoint the most effective components in a negotiating agent.There are two major advantages of distinguishing between the different components of a negotiating agent's strategy: first, it allows the study of the behavior and performance of the components in isolation. For example, it becomes possible to compare the preference learning component of all agents, and to identify the best among them. Second, we can proceed to mix and match different components to create new negotiation strategies., e.g.: replacing the preference learning technique of an agent and then examining whether this makes a difference. Such a procedure enables us to combine the individual components to systematically explore the space of possible negotiation strategies.To develop a compositional approach to evaluate and combine the components, we identify structure in most agent designs by introducing the BOA architecture, in which we can develop and integrate the different components of a negotiating agent. We identify three main components of a general negotiation strategy; namely a bidding strategy (B), possibly an opponent model (O), and an acceptance strategy (A). The bidding strategy considers what concessions it deems appropriate given its own preferences, and takes the opponent into account by using an opponent model. The acceptance strategy decides whether offers proposed by the opponent should be accepted.The BOA architecture is integrated into a generic negotiation environment called Genius, which is a software environment for designing and evaluating negotiation strategies. To explore the negotiation strategy space of the negotiation research community, we amend the Genius repository with various existing agents and scenarios from literature. Additionally, we organize a yearly international negotiation competition (ANAC) to harvest even more strategies and scenarios. ANAC also acts as an evaluation tool for negotiation strategies, and encourages the design of negotiation strategies and scenarios.We re-implement agents from literature and ANAC and decouple them to fit into the BOA architecture without introducing any changes in their behavior. For each of the three components, we manage to find and analyze the best ones for specific cases, as described below. We show that the BOA framework leads to significant improvements in agent design by wining ANAC 2013, which had 19 participating teams from 8 international institutions, with an agent that is designed using the BOA framework and is informed by a preliminary analysis of the different components.In every negotiation, one of the negotiating parties must accept an offer to reach an agreement. Therefore, it is important that a negotiator employs a proficient mechanism to decide under which conditions to accept. When contemplating whether to accept an offer, the agent is faced with the acceptance dilemma: accepting the offer may be suboptimal, as better offers may still be presented before time runs out. On the other hand, accepting too late may prevent an agreement from being reached, resulting in a break off with no gain for either party. We classify and compare state-of-the-art generic acceptance conditions. We propose new acceptance strategies and we demonstrate that they outperform the other conditions. We also provide insight into why some conditions work better than others and investigate correlations between the properties of the negotiation scenario and the efficacy of acceptance conditions.Later, we adopt a more principled approach by applying optimal stopping theory to calculate the optimal decision on the acceptance of an offer. We approach the decision of whether to accept as a sequential decision problem, by modeling the bids received as a stochastic process. We determine the optimal acceptance policies for particular opponent classes and we present an approach to estimate the expected range of offers when the type of opponent is unknown. We show that the proposed approach is able to find the optimal time to accept, and improves upon all existing acceptance strategies.Another principal component of a negotiating agent's strategy is its ability to take the opponent's preferences into account. The quality of an opponent model can be measured in two different ways. One is to use the agent's performance as a benchmark for the model's quality. We evaluate and compare the performance of a selection of state-of-the-art opponent modeling techniques in negotiation. We provide an overview of the factors influencing the quality of a model and we analyze how the performance of opponent models depends on the negotiation setting. We identify a class of simple and surprisingly effective opponent modeling techniques that did not receive much previous attention in literature.The other way to measure the quality of an opponent model is to directly evaluate its accuracy by using similarity measures. We review all methods to measure the accuracy of an opponent model and we then analyze how changes in accuracy translate into performance differences. Moreover, we pinpoint the best predictors for good performance. This leads to new insights concerning how to construct an opponent model, and what we need to measure when optimizing performance.Finally, we take two different approaches to gain more insight into effective bidding strategies. We present a new classification method for negotiation strategies, based on their pattern of concession making against different kinds of opponents. We apply this technique to classify some well-known negotiating strategies, and we formulate guidelines on how agents should bid in order to be successful, which gives insight into the bidding strategy space of negotiating agents. Furthermore, we apply optimal stopping theory again, this time to find the concessions that maximize utility for the bidder against particular opponents. We show there is an interesting connection between optimal bidding and optimal acceptance strategies, in the sense that they are mirrored versions of each other.Lastly, after analyzing all components separately, we put the pieces back together again. We take all BOA components accumulated so far, including the best ones, and combine them all together to explore the space of negotiation strategies.We compute the contribution of each component to the overall negotiation result, and we study the interaction between components. We find that combining the best agent components indeed makes the strongest agents. This shows that the component-based view of the BOA architecture not only provides a useful basis for developing negotiating agents but also provides a useful analytical tool. By varying the BOA components we are able to demonstrate the contribution of each component to the negotiation result, and thus analyze the significance of each. The bidding strategy is by far the most important to consider, followed by the acceptance conditions and finally followed by the opponent model.Our results validate the analytical approach of the BOA framework to first optimize the individual components, and then to recombine them into a negotiating agent
Property A and affine buildings
No full textYu's Property A is a non-equivariant generalisation of amenability introduced in his study of the coarse Baum Connes conjecture. In this paper we show that all affine buildings of type A2, B2 and G2 have Property A. Together with results of Guentner, Higson and Weinberger, this completes a programme to show that all affine building have Property A. In passing we use our technique to obtain a new proof for groups acting on buildings.The author was supported by EPSRC postdoctoral fellowship EP/C53171X/1.<br/
Social capital and post-disaster mental health
No full textBackground: Despite national and international policies to develop social capital in disaster-affected communities, empiric evidence on the association between social capital and disaster mental health is limited and ambiguous.
Objective: The study explores the relationship between social capital and disaster mental health outcomes (PTSD, anxiety, and depression) in combination with individual factors (appraisal, coping behavior, and social support).
Design: This is a community-based cross-sectional study in a flood-affected town in northern England. The study is part of the MICRODIS multi-country research project that examines the impact of natural disasters. It included 232 flood-affected respondents.
Results: The findings showed that a considerable part of the association between cognitive and structural social capital and mental health is exerted through individual appraisal processes (i.e. property loss, primary and secondary appraisal), social support, and coping behavior. These individual factors were contingent on social capital. After the inclusion of individual characteristics, cognitive social capital was negatively related to lower mental health problems and structural social capital was positively associated to experiencing anxiety but not to PTSD or depression. Depression and anxiety showed a different pattern of association with both components of social capital.
Conclusions: Individual oriented stress reducing interventions that use appraisal processes, social support, and coping as starting points could be more effective by taking into account the subjective experience of the social context in terms of trust and feelings of mutual support and reciprocity in a community. Findings indicate that affected people may especially benefit from a combination of individual stress reducing interventions and psychosocial interventions that foster cognitive social capital
- …
