12,515 research outputs found
Bull, Christopher
No full textMemorial Statement for Professor Christopher Bull who died in 2002. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
Prediction of the binding free energies of inhibitors of epidermal growth factor receptor kinase and the identification of the dynamics thereof
No full textEpidermal Growth Factor Receptor (EGFR) kinase is a signalling protein implicated in a number of cancers, including non-small cell lung cancer (NSCLC). As well as activating mutations of EGFR kinase being oncogenic, the prognosis of NSCLC correlates with the impact of EGFR mutations on inhibitor binding affinities. However, treatment with tyrosine kinase inhibitors is particularly vulnerable to resistance mutations. The exact mechanisms by which EGFR kinase mutations impart activation or resistance has not been clearly defined at an atomistic level, and attempts to elucidate these mechanisms in silico are hindered by the long time scales over which the conformational dynamics of EGFR kinase occur. In this thesis rigorous free energy calculations are employed to investigate the relative binding free energy of inhibitors of EGFR kinase, and elucidate the hydration of the binding pocket. Additionally, various enhanced molecular dynamics (MD) sampling methods are utilised alongside conventional MD to investigate their ability to overcome the challenge of the long time scales of conformational change in EGFR kinase. The complementary use of dimensionality reduction techniques such as principal components analysis and locally scaled diffusion map analysis is shown to be useful in characterising long time scale dynamics, as well as in validating the sampling of enhanced MD methods. Using these techniques alongside traditional analyses, new insight into the role of three activating mutations was gained; however, the results suggest that accessible simulation times are still too short, implying a continuing role for enhanced MD methods in the future
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
AME025 configuration
No full text<p>The AME025 is based on the WED025_NEMO_chrisbull.tar.gz created by Christopher Bull. More details can be found at https://zenodo.org/record/3767939.</p>
GP benchmark: Engineering a crowd-sourcing platform for real-time understanding of personality and cognitive biases in clinical error
No full textErrors in medicine are a significant problem, highlighted as a global safety priority. General Practice is one clinical arena where error is more likely due to clinical decisions being made on a background of clinical complexity, undifferentiated symptoms and diseases, and multiple other factors as yet unquantified. Interventions designed to reduce error are either underutilised, untested, fail to produce lasting results, are designed on inadequate knowledge, or have failed to appreciate the interaction of multiple factors, both cognitive and systemic. We present a potential solution, in the form of GP Benchmark. GP Benchmark is an online simulation environment and tool designed to test clinical decision making in a group of practicing General Practitioners. Its aim is to address two pressing requirements: 1) the need to capture clinical decision making in real-time, in the context of personality, cognitive bias and environmental factors, and 2) the need to provide a validated platform that models the clinical environment so future intervention decisions may be tested without risking patient safety. We highlight the requirements satisfied for implementing GP Benchmark, the plans for validation, and discuss how GP Benchmark will be used to identify further requirements necessary to develop the environment into a tool for testing clinical decision support systems and error prevention strategies
Matt Christopher Papers - Accession 1309
No full textThe collection includes letters written by the children’s book author, Matt Christopher, to his son, Marty Christopher. Many of the letters also contain newspaper articles of interest to Matt Christopher, which deal with local sports teams, his writing career, his participation in an exhibition baseball game against the New York Giants in 1938, and other of general interest. Most of the letters are personal in nature, however, a majority of the letters delve into Matt Christopher’s writing career, personal interests, the author’s health, as well as his family life.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2649/thumbnail.jp
Matt Christopher Papers - Accession 1221
No full textMatt Christopher (1917-1997) was a prolific author of children’s books having written over 100 books as well as over 300 short stories, articles, poems, and screenplays. Most of his writings dealt with sports themes, but he also wrote fantasy and mystery themed stories as well. The Matt Christopher Papers consist of both published and unpublished manuscripts, articles, and short stories. Also included are personal and business correspondence, biographical information, scrapbooks, photographs, and memorabilia.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1976/thumbnail.jp
Christopher Bull Politics in Packaged Software Implementation Politics in Packaged Software Implementation
No full textThe academic literature relating to the political issues of information systems is fairly well established. However, there are relatively few empirical studies relating to the political issues associated with the organisational implementation of package software. The aim of this paper is to offer a modest contribution via case study research with an analysis of a packaged software implementation at an organisation based in the United Kingdom. The study raises issues that support and question some of the notions inherent in many political theories relating to information systems. The study also highlights the multifarious and complex nature of politics in the development of packaged software implementation
Dr. Christopher von Rueden – Faculty Author Interview
No full textDr. Christopher von Rueden, an anthropologist and Assistant Professor in the Jepson School of Leadership Studies, discusses a recent article entitled, “Men’s status and reproductive success in 33 non-industrial societies: Effects of subsistence, marriage system, and reproductive strategy,” which he co-authored with Dr. Adrian Jaeggi, an anthropologist at Emory University. Their findings were recently published in the journal, Proceedings of the National Academy of Sciences
ESP Across Cultures
No full textThis present volume constitutes the third online edition of ESP Across Cultures.
The decision to change from a paper-based to an online edition has undoubtedly
been beneficial in terms of enjoying greater visibility within the international academic
community. One thing that has not changed over the years, however, since
the inception of the journal in 2004, has been the policy of double-blind peer reviewing,
which means that only a selected number of the papers submitted end up as
being published.
There are seven papers in the current issue, each one analysing a particular aspect
of English for Specific Purposes from a cross-cultural perspective.
The first paper, by Hmoud S. Alotaibi, focuses on research article introductions
in Arabic, analysing the extent to which scholars writing in Arabic in the sphere of
education adhere to the CARS (Create A Research Space) model delineated by John
Swales which was elaborated in particular with regard to the academic conventions
widely adopted in the English-speaking world. Instead of restricting the investigation
to the introductory section as past studies in this field did, the author examines
all of the subheadings and he concludes that all introductions include Move 2 in a
subheading entitled the Problem of the Study, a result that contradicts previous
findings where the paucity of Move 2 was common in non-English RAs, and especially
in Arabic ones.
Patrizia Anesa analyses the websites of the main arbitration centres operating in
Asia from a textual perspective to define how they are discursively constructed and
can be used as promotional tools, thereby helping us to evaluate the importance assumed
by internationalization processes or by local cultural elements in promoting a
particular centre as a seat for international arbitration. She concludes that while
some scholars argue that we are witnessing the ‘Asianization’ of arbitration, with
the increasing bargaining power of Asian parties, on the other hand a phenomenon
of ‘Universal Arbitration’ is also emerging, i.e. a form of convergence of how disputes
are resolved so that parties of any nationality can operate in the same way
with ever fewer language barriers.
In their paper, Mahmood Reza Atai and Fatemeh Asadnia examine the communicative
and promotional function of university homepages by looking at the ‘university
overview’, ‘university mission statement’, and ‘university introduction at a
glance’ genres, using a corpus of 210 texts selected from homepages of the top 500
universities ranked by the Academic Ranking of World Universities. The findings
demonstrated that the three genres shared communicative purposes, functional
units, certain moves and steps, socio-academic contexts, and discourse community
members that led to the formation of a genre set.
Gaetano Falco explores ways of using comics in an MA course on translation of
economic texts as a means of stimulating the interest of language students with no
economics skills in order to introduce economics-related lexis and improve thematic
competence in general. He observes that empirical research has shown that films
and comics can indeed be useful resources to teach economic translation to students
with no skills in economics. However, the author warns that the use of comics for
educational purposes may have its drawbacks, e.g. when students deal with complex
sign systems which embody complex economic concepts, where often the humorous
element is lost.
In her paper, Irina Khoutyz describes the differences in how scholars present
their findings in research articles (RA) in international journals in English and in
Beyza Björkman
Christian Burgers
Jan Chovanec
Anda-Elena Cretiu
Erika Dalan
John Douthwaite
Hanem El-Farahaty
Said Faiq
Silvia Ferreri
Inmaculada Fortanet-Gómez
Pedro Fuertes-Olivera
Giuliana Garzone
Christoph Hafner
Ruba Khamam
Anna Loiacono
Geraldine Ludbrook
John McRae
Susan Petrilli
Silvia Pireddu
Tarja Salmi-Tolonen
Jeffrey Segrave
Charlotte Taylor
Margherita Ulrych
John Kenneth White
Jessica Williams
I hope you will enjoy the current issue of this journal and will make the most of
the free access to all past issues.
Christopher Williams
(Chief Editor)
6 FOREWORD
local journals in Russian. She then looks into the reasons for these differences, seeking
explanations from the sociocultural contexts in which these RAs were written,
as well as providing advice to local authors as to how to make their RAs more competitive
at the international level. The differences include the apparent lack of
structure of Russian RAs with respect to English RAs; the tendency in Russian authors
not to specify the purpose in writing a paper; and the tendency of Russian authors
to present the methodology used in less detail compared with English RAs.
Luisella Leonzini investigates the use of verbal and visual metaphors in economic-
media discourse within the context of the euro crisis by studying the correlation
between linguistic and pictorial metaphors and text-image intersemiotic relations.
The research is based on a cross-analysis of English and Italian editorial
articles published between 2009 and 2012. In both corpora, metaphorical realizations
frame the economic crisis which hit the single currency and the eurozone in
2009 as a partial collapse and hint at a possible return to stability in the form of a
recovery. The aim of this paper is to analyse the collapse/caduta and
recovery/ripresa metaphors across languages in the press.
Ian Robinson reports on using corpus linguistics to aid students in writing a creative
text. He looks at the available literature to help understand what is meant by
‘creativity’. A worksheet was prepared using a corpus linguistic analysis of modern,
English versions of the stories of the Brothers Grimm. This worksheet was constructed
with the use of a specialized corpus, and a stop-list was created which contained
single words as well as word clusters found in the tales. Students were then
asked to select some of these words and phrases to help them write stories which
were then analysed, and a follow-up questionnaire was used to elicit the students’
perceptions concerning creativity. The author concludes that creativity is essential
in EFL and that it is something to be fostered in students
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