118,289 research outputs found
Book review: 'Engineering philosophy', by Louis L. Bucciarelli
No full textReview of the book 'Engineering philosophy', by Louis L. Bucciarelli, published by Delft University Press Satelilte, 2003
ADMA, SDMA, L-Arginine and nitric oxide in allergic pediatric bronchial asthma
No full textPublished data regarding asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine (L-ARG) and nitric oxide fraction in exhaled air (FeNO) in pediatric bronchial asthma are limited. Many question remain open about plasma concentration of these substances. The aim of this study is to evaluate ADMA, SDMA, L-ARG and FeNO concentration in allergic pediatric mild asthmatic patients in respect to healthy subjects. In this case-control study 60 children (50 asthmatics and 10 healthy) underwent a complete clinical visit, baseline respiratory function, allergy tests and biochemical analyses. The statistical significance of the different concentrations between the two groups were studied using one-way analysis of variance (ANOVA). A p value less than 0.05 was considered statistically significant. The mean plasma ADMA (0.58 vs 0.68 micromol/L), SDMA (0.40 vs 0.45 micromol/L) and L-ARG (52.2 vs 74.13 micromol/L) concentration were significantly lower (p less than 0.001) in the asthmatic patients in respect to healthy subjects (control group). The concentration of FeNO was significantly higher in the asthmatic subjects in respect to the control group (9.18 vs 4.2 micromol/L; p less than 0.001). Low plasma concentrations of ADMA, SDMA, L-ARG and high concentration of FeNO are associated with bronchial asthma and indicate an important role in airway disease through NO metabolism
Louis L. Bucciarelli, Nancy Dworsky, Sophie Germain. An Essay in the History of the Theory of Elasticity
No full textLouis L. Bucciarelli, Nancy Dworsky, Sophie Germain. An Essay in the History of the Theory of Elasticity. In: Revue d'histoire des sciences, tome 35, n°2, 1982. pp. 175-176
TABLET IN THE COMPANY 'OF ACRONYMS
No full textNel corso di un ultradecennale lavoro di ricerca presso il DSC dell’Università degli Studi di Salerno, sono stati messi a punto nuovi metodi per l'indagine linguistica. L'attività è stata incentrata sull'approfondimento dei metodi e finalizzati, per gli interessati, all'individuazione di modalità di applicazioni curriculari per una moderna glottodidattica. Le applicazioni sono derivate dall’intuizione che la metodologia dei corpora applicata alla consultazione, analisi , riproduzione può essere di ausilio, sia in termini di analisi linguistiche avanzate, sia come strumento didattico per l’insegnamento. L’esperienza di ricerca e di sperimentazione condotta presso l’Università Cà Foscari di Venezia DSLCC e il DSU , mi ha permesso di trasformare in ipotesi operative concrete le ricerche fin qui condotte.
Pertanto lo scopo è stato di descrivere le funzioni dei corpora linguistici in questione e di fornire i risultati accurati di specifici software, quali (Tipe-Race) per l’analisi testuale automatica , (Acro-word), Human search converter con interfaccia Word per l’elaborazione di testi e per la riproduzione e riconversione del linguaggio parlato, (WorkTool) , a database approach to handle lexicon building and spotting token forms in sign languages. I risultati sono : Type-Race è un corpus linguistico di consultazione realizzato in ambito didattico quasi un (syllabus) , affiancato da un file text , da un file text per la codicifica e la produzione di un’oralità in tempi reali e un file di text per la produzione e la trasduzione . Wacro –word è un software multifunzionale di utilizzo per la ricerca lessicografica , per la didattica linguistica. universitaria e si compone: - una base dati (WT), detta ( linguistic corpus), per interrogazioni ed analisi e lettura “quantitativa” del corpus linguistico ; -file text , detto (Human search converter) , per la produzione, manipolazioni della parola, del sintagma e con riformulazione testo; -file text detto, (beyond language) , transduction , decoding , translation ; - Trasmissione in real time . (WorkTool) corpus linguistico per la didattica della lingua dei segni
Louis L. Bucciarelli, Nancy Dworsky, Sophie Germain. An Essay in the History of the Theory of Elasticity
No full textLouis L. Bucciarelli, Nancy Dworsky, Sophie Germain. An Essay in the History of the Theory of Elasticity. In: Revue d'histoire des sciences, tome 35, n°2, 1982. pp. 175-176
Fostering the understanding of multi-representational examples by self-explanation prompts
No full textBerthold K, Renkl A. Fostering the understanding of multi-representational examples by self-explanation prompts. In: Bara BG, Barsalou L, Bucciarelli M, eds. Proceedings of the CogSci 2005. Mahwah, NJ: Erlbaum; 2005: 250-255
Characterization of toad liver glutathione transferase
No full textThe major form of glutathione transferase from the toad liver previously designed as Bufo bufo liver GST-7.6 (A. Aceto, B. Dragani, T. Bucciarelli, P. Sacchetta, F. Martini, S. Angelucci, F. Amicarelli, M. Miranda and C. Di Ilio, Biochem. J. 289 (1993) 417-422) has been characterized. According to its partial amino acid sequence, the toad enzyme may be included in the pi class GST and named bbGST P2-2. However, bbGST P2-2 appears to be immunologically, structurally and kinetically distinct from any other members of pi family, including bbGST P1-1, suggesting that it may constitute a subset of pi class GST. The data support the hypothesis that the transition from aquatic to terrestrial life causes a switch of the GST amphibian pattern promoting the expression of a GST form (bbGST P2-2) able to counteract, with higher efficiency, the toxic effects of reactive metabolites of oxidative metabolism and those of hydrophobic xenobiotics
Síndrome antifosfolipídico catastrófico
No full text[spa] INTRODUCCIÓN: El síndrome antifosfolipídico catastrófico fue descrito por Asherson en el año 1992 como una variante del síndrome antifosfolipídico (SAF) que conduce a insuficiencia multiorgánica, caracteriza por la oclusión trombótica de los vasos de pequeño calibre, que se produce en un breve período de tiempo en presencia de anticuerpos antifosfolipídicos. Representa aproximadamente el 1% de los pacientes con SAF, pero la mortalidad es mayor del 50%. Las causas y los factores pronósticos que influyen es esta elevada mortalidad son desconocidos.HIPÓTESIS: El SAF catastrófico debería ser considerado en el diagnóstico diferencial de los pacientes con fallo multiorgánico (FMO), síndrome de distrés respiratorio agudo (SDRA) y anenia hemolítica microangiopática (AHM). El esquema terapéutico combinando glucorticoides (GC) junto a anticoagulación efectiva (AC) y recambio plasmático (RP), sería es el que consigue mayores tasas de supervivencia. Por tanto, la utilización de esta triple terapia podría mejorar la evolución de estos pacientes.OBJETIVOS: Analizar las características clínica y biológicas de los pacientes con SAF catastrófico, especialmente en aquellos que desarrollan SDRA y AHM. Determinar las causas y los factores pronósticos que condicionan su elevada mortalidad como así también la influencia del tratamiento en la evolución de estos enfermos.MATERIAL Y MÉTODOS:Debido a la baja prevalencia del síndrome es imposible que un solo centro reúna un número de pacientes suficientes para realizar estudios de investigación, por lo que se creó un registro internacional denominado "CAPS registry" con el fin de reunir todos los pacientes con SAF catastrófico. El servicio de enfermedades autoimmnes del Hospital Clínico de Barcelona es el centro coordinador para la recepción de la información y los directores y doctorando de esta tesis son los responsables del diseño, confección y actualización del mismo. El registro está patrocinado por el Europeam Forum on Antiphospholipid Antibodies y se diseñó como un portal abierto de libre acceso a través de la siguiente dirección: www.med.ub.es /MIMMUN/FORUM/CAPS. HTM. TRABAJOS PUBLICADOS:1. Espinosa G, Bucciarelli S, Cervera R et al. Thrombotic hemolitic microangiopathic anaemia and antiphospholipid antibodies. Ann Reum Dis 2004; 63: 730-736 (IF 6,96). 46 pacientes con AHM y anticuerpos antifosfolipídicos (aFL) fueron revisados. La presentación clínica fué: síndrome hemolítico urémico (26%), SAF catastrófico (23%), purpura trombótica trombocitopénica (13%) y síndrome HELLP (4%). El 70 % de los pacientes que recibieron recambio plasmático se recuperaron. La mortalidad fué del 22%.2. Bucciarelli S, Espinosa G, Cervera R. The acute respiratory distress syndrome in catastrophic antiphospholipid syndrome.Ann Rheum Dis 2006; 65:81-86 (IF : 6,96). El 68 % de los pacientes tuvieron afectación pulmonar y en el 31% se manifestó como SDRA. El 70% de los pacientes en los que se dispuso de anatomía patológica presentaron microtrombosis.3. Bucciarelli S, Espinosa G, Cervera R et al. Mortality in the catastrophic antiphospholipid syndrome. Prognostic factors in a series of 250 patients. Arthritis Rheum 2006 (en prensa) (IF: 7,42) La mortalidad global fue del 44%. La principal causa de muerte fue la afectación neurológica (27,9%) seguida por la afectación cardiaca y las infecciones en un 19,8%. La presencia de lupus eritematoso sistémico se asoció a una mayor mortalidad. La mayor tasa de recuperación estuvo se obtuvo con la utilización de GC+AC+RP. La mortalidad disminuyó un 20% después del 2001 asociada a una mayor utilización de la terapia combinada con GC+AC+RP.CONCLUSIONES:El SAF catastrófico debe ser considerado en el diagnóstico diferencial de los pacientes con FMO, SDRA y AHM. El tratamiento combinado con AC+GC+RP debe ser considerada como terapia de primera línea en los pacientes con SAF catastrófico.[eng] "CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME"BACKGROUND: The term catastrophic antiphospholipid syndrome (APS) was proposed by Asherson in 1992 for defining an accelerated form of APS resulting in multiorgan failure, developed in a very short period of time. Although patients with catastrophic APS represent less than 1% of patients with APS, the mortality rate is more than 50%. The causes of this high mortality are still unknown.HYPOTHESES: The catastrophic APS would be considered as differential diagnosis among multiorgan dysfunction, thrombotic haemolytic microangiopathic anaemia and acute respiratory distress syndrome. A higher recovery rate would be associated with combined treatment with anticoagulation + corticosteroids + plasma exchange (AC+CS+PE). OBJECTIVES: to analyse the clinical and laboratory features of patients with catastrophic APS mainly in those patients who develop thrombotic miroangiopathic anaemia (THMA) and acute respiratory distress syndrome (ARDS). To assess the main causes of death and the prognostic factors that can influence mortality in patients with catastrophic APS.METHOD: We analysed the patients with catastrophic APS included in the "CAPS registry" in order to achieve the objectives.RESULTS: FIRST STUDY: 46 patients were reviewed with AMTH and aPL. The clinical presentations were: hemolytic-uremic syndrome (26%), catastrophic APS (23%), thrombotic thrombocytopenic purpura (13%), and HELLP syndrome (4%). Recovery occurred in 70% of episodes treated with Plasm Exchange. SECOND STUDY: Pulmonary involvement was reported in 68% patients with catastrophic APS and 31% of them were diagnosed as having ARDS. Microthromboses was present in 70% patients. THIRD STUDY: Death occurred in 44%. Cerebral involvement was considered the main cause of death (27.2%) followed by cardiac involvement and infection (19.8% one each). The presence of systemic lupus erythematosus was associated with a higher mortality. A higher recovery rate was associated with combined treatment with anticoagulation + corticosteroids + plasma exchange (AC+CS+PE) (77.8%). The mortality decreased 20% from 2001 associated with the higher use rate of combined treatment with AC+CS+PE and/or IVIg.CONCLUSIONS: The catastrophic APS should be considered as differential diagnosis among multiorgan dysfunction, thrombotic haemolytic microangiopathic anaemia and acute respiratory distress syndrome. The combined therapy with AC+CS+PE should be the first line of therapy in patients with catastrophic APS
Wendt T, Harja E, Bucciarelli L, Qu W, Lu Y, Rong LL, Jenkins DG, Stein G, Schmidt AM, Yan SF RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes
No full textPrevious studies demonstrated that induction of diabetes with streptozotocin (stz) accelerated atherosclerosis in hyperlipidemic apo E null (-/-) mice. Blockade of the Receptor for Advanced Glycation Endproducts (RAGE) in those animals suppressed acceleration of atherosclerotic lesion area, in a manner independent of changes in levels of glucose, insulin or lipids. In the present studies, we extended these concepts to a murine model of type 2 diabetes, and bred apo E -/- mice into the db/db background. Db/db mice are a model of obesity and insulin resistance-mediated hyperglycemia. Compared to apo E -/- m/db (non-diabetic) mice, apo E -/- db/db (diabetic) mice displayed accelerated atherosclerosis at the aortic sinus. Consistent with an important role for RAGE in this process, administration of soluble (s) RAGE, the extracellular ligand-binding domain of RAGE, resulted in significantly reduced atherosclerotic lesion area in a glycemia- and lipid-independent manner. In parallel, apo E -/- db/db mice displayed RAGE-dependent enhanced expression of Vascular Cell Adhesion Molecule-1, tissue factor and matrix metalloproteinase (MMP)-9 antigen/activity in aortae compared to non-diabetic animals. In addition, consistent with the premise that upregulation of RAGE ligands and RAGE occurs even in the non-diabetic, hyperlipidemic state, albeit to lesser degrees than in diabetes, administration of sRAGE to apo E -/- m/db mice resulted in decreased atherosclerotic lesion area at the aortic sinus. Taken together, these findings establish a new murine model for the study of atherosclerosis in type 2 diabetes and highlight important roles for RAGE in proatherogenic mechanisms in hyperglycemia triggered by insulin resistance
Information and communication:two special issues for Geomatics
No full textInformation Systems may be considered as a part of universal media. The survey and mapping disciplines, particularly Photogrammetry, Remote sensing and GIS, can give very important contribution to many human activities, but they can also be negatively used to support, in very sophisticated ways, the escalation of armies, wars and destruction: in many cases of warfare, information is vital, regardless for the aim.. So some form of control is mandatory on the part of right-minded scientists and technicians: Human Sciences may be of great help for a better interpretation of information
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