881 research outputs found
Robert Warner and his Fight for Independence of Archives
No full textThis article is dedicated to the life and work of the 6th Archivist of the U.S.A. R. M. Warner, his struggle for the independence of the National Archives of the USA from the United States General Services Administration, the events of XXI International Conference of the Round Table on Archives, CITRA, (Kuala Lumpur, Malaysia), that was held in a complex international setting during the Lebanon War in 1982. Defending the State of Israel’s right to participate in the conference, R. M. Warner proved that the International Council on Archives is a professional organization of archivists around the world and cannot be subjected to political influence. A leading role in the personality of the head of the Archives is played by vocational education, which allows them to understand the essence of things, to experience all the facets of the problems of his profession and the field, which they manage. Gained experience is also very important, not only in the professional area, but also in the area of historical and archival science. Of course, the leader must possess personal communication skills and a certain charisma. The most important criterion of the head of the Archives is their non-participation in political parties and radical religious movements. Robert Warner met all these requirements. Not many would dare to risk their careers and confront the powers that be in upholding the principle of «archives out of politics». The author also focuses on the key figures of the described events – the archivists of Israel, the Soviet Union and Malaysia
New beginnings in collaborative conservation
No full textPresented at the Bridging the gap: collaborative conservation from the ground up conference, September 8-11, 2009, Colorado State University, Fort Collins, Colorado, sponsored by the Center for Collaborative Conservation, https://collaborativeconservation.org/. This conference brought together people with experience working collaboratively to achieve both conservation and livelihood goals in tribal nations, rangelands, forests, watersheds, agricultural lands, and urban areas. Ed Warner is a noted philanthropist and conservationist. In 2005, Colorado State University named the College of Natural Resources after him following a major gift that also founded the Center for Collaborative Conservation as part of the college. His work as an independent petroleum geologist culminated in his discovery and participation in Jonah Field and the first commercial development of Pinedale Field, located adjacent to Jonah Field in Sublette County, Wyoming. Jonah and Pinedale combined represent the third largest gas accumulation ever discovered within the continental United States. Warner retired from the natural gas industry at the end of 2000 to pursue philanthropy full time. In 2005, he placed forty-fifth on the Slate 60 list of American Philanthropy. He has made major gifts to Colorado State University, the Sand County Foundation, MIT, Grand Valley State University and the Colorado Conservation Trust. Warner has been a visiting lecturer for the American Association of Petroleum Geologists and holds two honorary faculty positions at CSU, a faculty affiliate position in the Dept. of Geosciences, and a professorship in Cooperative Conservation. He has lectured at CSU, Stanford, MIT, Texas A and M, Grand Valley State University, Missouri State University and Cape Town University. Although Warner occasionally lectures on topics in geology, most of his current lectures are focused upon cooperative conservation. He has been professionally published in three fields: geology, conservation biology and virology. He also writes book reviews for Denver-based Bloomsbury Review. He is a trustee or director of the Denver Museum of Nature and Science, the Sand County Foundation, the Explorers Foundation and is a past trustee of the Geological Society of America Foundation and the American Geological Institute Foundation. He is also an advisor to the Colorado Cattlemen's Agricultural Land Trust. Warner earned a M.S. degree from UCLA and a B.S. degree from CSU, both in geology.Collaborative conservation requires a great deal of work in order to succeed. Innovations such as inclusiveness of participation, use of market-based incentives, landscape or even eco-region scale of projects, protection of property rights and negotiation instead of litigation lead to testable outcomes. The development of new tools such as ecosystem services, the use of cost/risk analysis and long-term monitoring—all developed within an adaptive management approach—give us a chance to get the available funds working for us on the ground
Equity in unequal deductions : implications of income tax rules in Ghana and Nigeria
No full textIn many African countries, the amount of personal deduction for income tax purposes increases with the taxpayer's income. At first glance, this appears to give larger tax breaks to the rich than to the poor. On closer examination, this notion turns out to be false. As this paper shows, each tax system with"income dependent tax deductions"(IDTDs) is fully equivalent to a particular conventional progressive tax system with standard deductions. One implication for comparative tax research is that the tax schedule of a country that uses IDTDs should not be compared directly with a conventional tax schedule in another country. Existing cross-country work on tax deductions and marginal tax rates generally fails to recognize that IDTDs invalidate a straightforward comparison. To make the two systems comparable, a transformation like the one suggested in this paper is needed.Public Sector Economics&Finance,Environmental Economics&Policies,Tax Policy and Administration,Taxation&Subsidies,Governance Indicators
Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle.
No full textDetermining the sub-cellular localization of a protein within a cell is often an essential step towards understanding its function. In Caenorhabditis elegans, the relatively large size of the body wall muscle cells and the exquisite organization of their sarcomeres offer an opportunity to identify the precise position of proteins within cell substructures. Our goal in this study is to generate a comprehensive "localizome" for C. elegans body wall muscle by GFP-tagging proteins expressed in muscle and determining their location within the cell. For this project, we focused on proteins that we know are expressed in muscle and are orthologs or at least homologs of human proteins. To date we have analyzed the expression of about 227 GFP-tagged proteins that show localized expression in the body wall muscle of this nematode (e.g. dense bodies, M-lines, myofilaments, mitochondria, cell membrane, nucleus or nucleolus). For most proteins analyzed in this study no prior data on sub-cellular localization was available. In addition to discrete sub-cellular localization we observe overlapping patterns of localization including the presence of a protein in the dense body and the nucleus, or the dense body and the M-lines. In total we discern more than 14 sub-cellular localization patterns within nematode body wall muscle. The localization of this large set of proteins within a muscle cell will serve as an invaluable resource in our investigation of muscle sarcomere assembly and function
Voci sovversive e gerarchie familiari in "They Make a Desert and Call It Peace" di Marina Warner
No full textThis essay examines the way Marina Warner's radio play They Make a Desert and Call it Peace (2014) and its fictional reworking of contemporary news such as the Bloody Sunday report and the investigation of the Gaza Flotilla Raid of 30 May 2010. After a presentation of the development of radio plays in England, the essay shows what interest they have generated among feminist writers and how Warner uses the voice of women in her play, which also serves as a rewriting of the biblical story of Salome, to question the transmission of the memory of traumatic events such as the Bloody Sunday. The play overturns the point of view from that of the master narrative, emphasized by media and institutional voices, to that of unheard witnesses. The essay analyses the way Warner works on voices and multivocality to offer a comparison between the different points of view, that of a father, a former soldier who has taken part in violent missions, and his daughter’s: the author shows how she questions the repression systems of governments and the narration of mainstream history taking the defense of minority groups in her society
BR96-doxorubicin conjugate (BMS-182248) versus doxorubicin: a comparative toxicity assessment in rats
No full textThe toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m(2) (conjugated doxorubicin doses of 14.7, 34.8, and 74 mg/m(2), respectively) and compared to that obtained from administration of free doxorubicin at single doses of 33.6 and 72 mg/m(2) (approximately equivalent to that contained in the 1,200- and 2,550-mg/m(2) doses of BMS-182248, respectively). Necropsies were conducted on day 8, upon death/moribund sacrifice, or after an approximate 3-mo observation period following completion of treatment. Death/moribundity of all rats that received 72 mg/m(2) and of 9 of 20 rats given 33.6 mg/m(2) free doxorubicin were attributed primarily to delayed cardiotoxicity and glomerulonephropathy. With BMS-182248, death from glomerulonephropathy and cardiotoxicity occurred in only 4 of 20 rats given 2,550 mg/m(2) (74 mg/m(2) doxorubicin equivalent). No deaths or cardiotoxicity occurred in rats given 508 or 1,200 mg/m(2) BMS-182248. Additional effects noted with either drug included testicular atrophy, axonal degeneration of sciatic nerve and nerve tracts of brain and spinal cord, teeth (incisor) abnormalities, thymic atrophy, bone marrow hypocellularity, splenic lymphoid and red-pulp depletion, and increased extramedullary hematopoiesis in the spleen and liver. Also noted were altered chief cells in the stomach, vacuolation of adrenal gland and corpora lutea in the ovary, uterine and seminal vesicle atrophy, ulceration and myocyte regeneration/degeneration in the tongue, increased osteoclasts and osteoblasts in bone, and lymphoid hyperplasia of mandibular lymph node. In general, these effects were more severe in doxorubicin-treated rats. All changes observed with EMS-182248 were considered primarily due to the effects of doxorubicin and were substantially less severe (most notably cardiotoxicity) compared to those produced by an equivalent amount of doxorubicin.PT: J; NR: 0; TC: 10; J9: TOXICOL PATHOL; PG: 16; GA: PX206Source type: Electronic(1
Summary report on the geology and mineral resources of the Poker Jim Ridge and Fort Warner areas of the Hart Mountain National Antelope Refuge, Lake County, Oregon
No full text"A compilation of available geologic information."L. Summary report on the geology and mineral resources of the Harney Lake and Malheur Lake areas of the Malheur National Wildlife Refuge, north-central Harney County, Oregon / by George W. Walker and Donald A Swanson. -- M. Summary report on the geology and mineral resources of the Poker Jim Ridge and Fort Warner areas of the Hart Mountain National Antelope Refuge, Lake County, Oregon / by George W. Walker and Donald A Swanson.Title from PDF title page (viewed on April 8, 2019).This archived document is maintained by the State Library of Oregon. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the State Library of Oregon U.S. Government Publications Collection.Text in English
Pathogen Dose in Animal Models of Hemorrhagic Fever Virus Infections and the Potential Impact on Studies of the Immune Response
No full textViral hemorrhagic fever viruses come from a wide range of virus families and are a significant cause of morbidity and mortality worldwide each year. Animal models of infection with a number of these viruses have contributed to our knowledge of their pathogenesis and have been crucial for the development of therapeutics and vaccines that have been approved for human use. Most of these models use artificially high doses of virus, ensuring lethality in pre-clinical drug development studies. However, this can have a significant effect on the immune response generated. Here I discuss how the dose of antigen or pathogen is a critical determinant of immune responses and suggest that the current study of viruses in animal models should take this into account when developing and studying animal models of disease. This can have implications for determination of immune correlates of protection against disease as well as informing relevant vaccination and therapeutic strategies
Narrative art and act in the fourth gospel: aspects of the Johannine point of view
No full textThis thesis assumes that the narrative form of the Fourth Gospel is important for understanding the Gospel's meaning. Narrative is a communicative transaction whereby meaning is transmitted from author to reader via the way the story is told. Meaning is also established by overt speech-acts, and the 'act' performed in the overall structuring of the story. It arises within a context of rule-governed speech behaviour which determines parameters and implications that inform understanding. The Gospel's narrative form meets with readers' conventional expectations about how it relates to ostensive historical reality. Factors internal and external help determine genre. Part one examines aspects of the Gospel's narrative art. The way in which the narrative situation varies over the course of the narrative is outlined. The implied author manipulates the narration to create a close association in the reader’s mind between the narrator and the beloved disciple. In John 3 the voice of the narrator merges with those of Jesus and John. These strategies have implications for the Gospel's theological meaning and the relationship of the implied author to the story world. Speech-act theory elucidates the narrative act by which the implied author conveys the Gospel's message and seeks to induce belief in the reader. Part two considers the Gospel's relationship to historical reference. Factors which influence a decision as to whether or not the Gospel is to be taken as fictional are examined, for example, whether aspects of the narration suggest fictional discourse and whether the speech-acts operate within a 'pretended' world. Descriptive categories for the Gospel as natural narrative and 'display text' are proposed, as is a flexible model of genre, which modulates the poles of 'fiction' and 'history'. An analysis of the Temple Cleansing pericope provides illustration of the Gospel’s status as an historically-based, theological display text
Current research for a vaccine against Lassa hemorrhagic fever virus
No full textBryce M Warner,1 David Safronetz,2 Derek R Stein2 1Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; 2Zoonotic Diseases and Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Abstract: Lassa virus (LASV) is a rodent-borne arenavirus endemic to several West African countries that causes Lassa fever (LF). LF is typically mild but it can cause severe disease characterized by hemorrhagic fever and multi-organ failure. A current outbreak of LASV in Nigeria has seen greater than 300 cases with a case fatality rate of 22%. Currently, there are limited treatment options and no vaccine candidates are approved to prevent LASV infection. The Coalition for Epidemic Preparedness Innovations has identified LASV as an emerging pathogen of high consequence and this has resulted in a push for several preclinical vaccine candidates to be advanced toward clinical trials. Here, we discuss several important aspects of LASV infection including immunobiology, immune evasion, and correlates of protection against LF, which have been identified through animal models and human infections. In addition, we discuss several vaccine candidates that have shown efficacy in animal models that could be advanced toward clinical trials. The increased fatality rate seen in the recent LASV outbreak in Nigeria highlights the importance of developing effective treatment and prevention strategies against LF. The spike in LASV cases seen in West Africa has the potential for increased mortality and human-to-human transmission, making the development and testing of effective vaccines for LASV critical. Keywords: Lassa virus, Lassa fever, vaccine, therapeutics, prevention, pathogenesi
- …
