1,433 research outputs found
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
The Natural and Un-Natural History of Patients with Scimitar Syndrome: An Italian Multicentric Study
No full textOn exclusive h→Vl+l− decays
No full textWe study a set of exclusive decay modes of the Standard Model Higgs boson into a vector meson and a dilepton pair: h→Vl+l−, with V=Υ,J/ψ,φ, and l=μ,τ, determining the decay rates, the dilepton mass spectra and the V longitudinal helicity fraction distributions. In the same framework, we analyze the exclusive modes into neutrino pairs View the MathML source. We also discuss the implications of the recent CMS and ATLAS results for the lepton flavor-changing process h→τ+μ− on the h→Vτ+μ− decay mode
Tolerable degree of muscle sacrifice when harvesting a vastus lateralis or myocutaneous anterolateral thigh flap
No full textThe myocutaneous anterolateral thigh (ALT) and vastus lateralis (VL) flaps include a large muscle mass and a sufficient vascular pedicle, and they have been used for decades to reconstruct traumatic and acquired defects of the head and neck and extremities. In spite of these benefits, musculoskeletal dysfunction was reported in nearly 1 out of 20 patients at follow-up. It is unclear whether the recently proposed muscle-sparing flap-raising approach could preserve VL muscle function and whether patients at increased risk could benefit from such an approach. Therefore, we performed a predictive dynamic gait simulation based on a biological motion model with gradual weakening of the VL during a self-selected and fast walking speed to determine the compensable degree of VL muscle reduction. Muscle force, joint angle, and joint moment were measured. Our study showed that VL muscle reduction could be compensated up to a certain degree, which could explain the observed incidence of musculoskeletal dysfunction. In elderly or fragile patients, the VL muscle should not be reduced by 50% or more, which could be achieved by muscle-sparing flap-raising of the superficial partition only. In young or athletic patients, a VL muscle reduction of 10%, which corresponds to a muscle cuff, has no relevant effect. Yet, a reduction of more than 30% leads to relevant weakening of the quadriceps. Therefore, in this patient population with the need for a large portion of muscle, alternative flaps should be considered. This study can serve as the first basis for further investigations of human locomotion after flap-raising.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Biomechatronics & Human-Machine Contro
Anisotropy Indicators of High-Strength Steel 42H2GSNMA (VKS-1) and 30H2GSNVM (Vl-1d)
No full textПоставлены опыты по растяжению образцов из сталей 42Х2ГСНМА (ВКС-1) и 30Х2ГСНВМ (ВЛ-1 Д) с изменением ориентации образцов относительно оси прокатки. Выполнены расчеты и получены показатели анизотропии высокопрочных сталей 42Х2ГСНМА (ВКС-1) и 30Х2ГСНВМ (ВЛ-1 Д) в отожженном состоянии.Experiments on stretching samples of steels 42H2GSNMA (VKS-1) and 30H2GSNVM (VL-1D) with a change in the orientation of the samples relative to the rolling axis were carried out. Calculations have been carried out and anisotropy indices have been obtained for high-strength 42H2GSNMA (VKS-1) and 30H2GSNVM (VL-1D) steels in the annealed state.Автор выражает благодарность научному руководителю — доктору технических наук, профессору Ю.Н. Логинову.The author expresses gratitude to the scientific advisor — doctor of technical sciences, professor Yu.N. Login
A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders
No full textA synthetic human VL phage display library, created by the randomization of all complementarity-determining regions (CDRs) in a V L scaffold, was panned against three test antigens to determine the propensity of the library to yield non-aggregating binders. A total of 22 binders were isolated against the test antigens and the majority (20) were monomeric. Thus, human VL repertoires provide an efficient source of non-aggregating binders and represent an attractive alternative to human V H repertoires, which are notorious for containing high proportions of aggregating species. Moreover, the solubility of VLs, in contrast to VHs, appears much less CDR dependent. \ua9 The Author 2012. Published by Oxford University Press.Peer reviewed: YesNRC publication: Ye
B cells in lung cancer-not just a bystander cell: A literature review
No full textMetastatic lung cancer represents a significant global issue where it is responsible for the most cancer diagnoses and deaths worldwide. Treatment for advanced lung cancer has undergone a series of paradigm shifts from chemotherapy to targeted molecular agents to the most recent immunotherapy strategies. The most successful of the latter involves antibodies that block inhibitory receptors on tumor infiltrating T cells, thereby enhancing T cell activity against tumor cells. However, only a subset of patients demonstrate durable responses to these drugs and treatment resistance is common. Emerging evidence suggests that a critical role exists for B cells as more than a bystander immune cell in the tumor microenvironment (TME). However, this role is likely context-specific where B cells comprise distinct subtypes with unique effector functions that may result in anti- or pro-tumor effects. As such, the balance between various B cell subtypes affects the net B cell impact upon tumor immunity. To date, the factors needed to polarize B cell function toward anti-tumor activity are unclear. Understanding B cell biology in the lung cancer setting will help redefine and refine treatment strategies to augment anti-tumor immunity. This article presents a review of the literature describing the current knowledge of the development and function of B cells, and explores their role in lung cancer and potential as an immunotherapeutic strategy and as a predictive marker for response to immune checkpoint blockade
Testdatensatz-VL : Semantics Test
No full textAbstract (Deutsch)Abstract (Englisch)Project X-37B Formtest
Reading Library Catalogues and Indexes
No full textThis paper gives a brief description of some of the work undertaken by the Centre for Catalogue Research at the University of Bath. Some of the Centre’s research is concerned with visual factors affecting the design and performance of library catalogues and indexes. The involvement of computers in the generation of catalogues has enabled people’s performance to be studied with alternative catalogue displays. One of the critical factors is the number of entries which can be scanned per page, the more entries the shorter the search time. Another critical factor is the way keyboards in a title are displayed in relation to the context both of the other words in the title and the other entries in the catalogue. It is shown that major improvements are possible to the visual display of the information on some of the catalogue systems currently in use
Diagnostics for Visceral Leishmaniasis in low resource settings within East Africa
No full textThis report is the result of a graduation project in the domain of the Neglected Tropical Disease (NTD): Visceral Leishmaniasis (VL) in low resource settings in East Africa. The project aims to find promising ways to fit a technical principle, which is being developed at the TUDelft, in the context of VL. VL endemic regions in Eastern Uganda and North-Western were visited during a two-week field trip to understand the context of VL. VL is a parasitic disease which is endemic in several parts in the world including East Africa. The disease is strongly related to poverty and mainly persists in remote and poor areas where health care services are limited. VL affects the internal organs and is fatal if untreated. There are many barriers complicate access VL diagnostics and treatment, such as the limited number of facilities, large distances, lack of trained staff and low index of suspicion by health care workers. VL is often misdiagnosed as the symptoms of VL are similar to many other diseases. In addition, current diagnostic practices have limitations in their performance (unreliable), especially in East Africa. More reliable diagnostic practices require more advanced tools and skills which are not available in most VL endemic areas. Thus, there is a need for a more reliable diagnostic test for the African VL context. The technical principle can be integrated on a diagnostic test strip to test a patient for VL. Based on a sample, it can separate and amplify the pathogens and detect their DNA with a CRISPR/Cas9 system. The result is a colourimetric read-out which indicates whether or not the patient has VL. This technical principle is based on DNA detection, which enables reliable test results independent of someone’s immune system. Additional advantages of this technical principle are that it is quick and broadly applicable. To understand where the technical principle could be implemented, a session was held with the team of IDE and Applied Sciences (TUDelft). This session resulted in the creation of seven scenarios which represent unique ways to combine the features of the technical principle into a diagnostic test which fits a diagnostic setting in the context of VL and matches a local need. After evaluation with Médecins Sans Frontières, the two most ‘promising’ scenarios are selected based on the feasibility of the technical principle, the contextual fit and the local need. The two selected scenarios are: ‘Screening & Confirming” scenario and the “Test-of-cure” scenario.By detailing the selected scenarios, five variables where identified which clarify that the diagnostic setting influences the features of a diagnostic test. These are: 1) (geographic) location, 2) resource availability, 3) (medical) background of the user, 4) diagnostic moment, 5) patient status. Requirements are composed to see how the diagnostic setting affects the diagnostic test. The categorisation of the requirements and diagnostic setting variables have resulted in four different diagnostic tests - each with a unique set of requirements. Integrated Product Desig
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