474 research outputs found
Yesterday-Today-Tomorrow: An e-Learning Program on Migration
No full textThe present study presents an e-learning platform based on the educational programs carried out by Yesterday-Today-Tomorrow Association (YTT) and Roma Tre University. YTT is an independent Paris-based Educational & Humanitarian Non-Profit which combines visual language with learning tools to facilitate migrants’ and refugees’ inclusive processes, promote human-rights, the prevention of violent extremism, freedom, diverse, multi-ethnic and multi religious societies. YTT is also aimed at positively affecting national and international migration policy-making. Since 2016, YTT Association has been collaborating with thousands of refugees/migrants (from more than 50 nationalities, aged from 3 to 70 years old) in over 35 camps and squats across Europe/North Africa. They receive 3 sheets of paper and coloured pens and are invited to draw 3 sketches: one of their life before: Yesterday; one of their current life: Today; and one of their life imagined in the future: Tomorrow. These drawings define the YTT visual language, a raw, emotional and explicative language that speaks logically and directly to the audience
Portrait of John W. McCormack, Speaker of the House of Representatives.
No full textHandwritten inscription: \u27To Felton M. Johnston, my dearly valued friend with the respect and friendship of [John W. McCormack]\u27https://egrove.olemiss.edu/fmjohnston/1113/thumbnail.jp
I didn't raise my boy to be a soldier, I brought him up to be my pride and joy [first line of chorus]
No full textstrophic with choruspiano and voiceRespectfully dedicated to Every Mother--Everywhereads on back cover for Leo. Feist stock3190-4music same as Box 96 Item 148 (Item 149 is missing pages)Music is duplicated in 096.148.Music is duplicated in 096.149.Johns Hopkins University, Levy Sheet Music Collection, Box
096, Item 149Lyrics by Alfred Bryan. Music by Al. Piantadosi.McCormack & Irvingphoto by Unity of McCormack & Irving; Teller, Sons & Dorner, New Yor
I didn't raise my boy to be a soldier, I brought him up to be my pride and joy [first line of chorus]
No full textstrophic with choruspiano and voiceRespectfully dedicated to Every Mother--Everywhereads on back cover for Leo. Feist stock3190-4music same as Box 96 Item 148 (Item 149 is missing pages)Music is duplicated in 096.148.Music is duplicated in 096.149.Johns Hopkins University, Levy Sheet Music Collection, Box
096, Item 149Lyrics by Alfred Bryan. Music by Al. Piantadosi.McCormack & Irvingphoto by Unity of McCormack & Irving; Teller, Sons & Dorner, New Yor
Image theatre: Transforming perspectives through embodied responses to refugee drawings in Yesterday/Today/Tomorrow (Traceability is Credibility) at the 2017 Venice Biennale
No full textThis paper documents the drawings, installations, video works, and performances that were produced as part of Bryan McCormack’s Yesterday/Today/Tomorrow (Traceability is Credibility) conceptual work at the 2017 Venice Biennale in collaboration with Henry Bell and undergraduate students at Sheffield Hallam University. It also includes two videos: the first of which was part of McCormack’s installation, and illustrates the application of performance methods inspired by Augusto Boal’s Image Theatre techniques. The second video gives a brief impression of how these methods functioned in a live performance in Venice in May 2017
Today's lifestyles, tomorrow's cancers: Trends in lifestyle risk factors for cancer in low- and middle-income countries
No full textBackground: The global burden of cancer is projected to increase from 13.3 to 21.4 million incident cases between 2010 and 2030 due to demographic changes alone, dominated by a growing burden in low- and middle-income countries (LMICs). Lifestyle risk factors for cancer are also changing in these countries and may further influence this burden.Design: We consider examples of changes already occurring in population-level distributions of tobacco and alcohol consumption, body weight, and reproductive lives of women to gauge the magnitude of their projected impact on cancer incidence in future decades.Results: Trends in lifestyle factors vary greatly between settings and by sex. Some common trends point to considerable increases in cancers of the (i) lung in men due to tobacco smoking; (ii) upper aerodigestive tract (UADT) due to increasing tobacco and alcohol consumption, worse in men; (iii) colon from increasing body mass index, and alcohol and tobacco consumption; and (iv) in women, breast due particularly to consistent international trends of younger age at menarche, smaller family size, and, at postmenopausal ages, increasing body weight.Conclusions: In many LMICs, the future cancer burden will be worsened by changing lifestyles. Affected common cancer sites likely to experience the largest increases are lung, colon, UADT, and breast. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved
Revisiting res ipsa loquitur: Mccormack v Sportsdirect.Com Fitness Limited considered
No full textIn this article, the author considers the recent decision of the Sheriff Appeal Court in Mccormack v Sportsdirect.Com Fitness Limited [2025] SAC (Civ) 15 in which the maxim res ipsa loquitur was found to have been incorrectly applied by the sheriff court.<br/
Author response
No full textPerforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapid redistribution of Perforin-2 and is essential for its bactericidal activity. Enteric pathogens such as
Yersinia pseudotuberculosis
and enteropathogenic
Escherichia coli
disarm host cells by injecting cell cycle inhibiting factors (Cifs) into mammalian cells to deamidate the ubiquitin-like protein NEDD8. Because CRL activity is dependent upon NEDD8, Cif blocks ubiquitin dependent trafficking of Perforin-2 and thus, its bactericidal activity. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria.
DOI:
http://dx.doi.org/10.7554/eLife.06505.001
A wide range of bacteria and other microbes can infect animals and cause disease. Throughout evolution, these microbes and their hosts have been fighting never ending arms races in which the microbes deploy ever more elaborate weapons, while the hosts adapt to defend themselves. An animal's first line of defense is provided by its ‘innate’ immune system. This system is activated by the general features of microbial cells; for example, the molecules that make up the walls surrounding most bacteria. Microbes must defeat the innate immune system in order to cause disease, and ultimately to spread from one host to the next.
One component of innate immunity is a protein called Perforin-2 that is present in most, if not all, animal cells. This protein forms pores on bacterial cells, causing them to split open and die. However, it was not clear how Perforin-2 is switched on and what, if anything, bacteria do to counteract it. To address these questions, McCormack et al. infected human and mice cells with bacteria that cause serious diseases of the digestive tract.
The experiments show that when animal cells detect bacteria, or merely a fragment of their cell wall, a specific group of proteins, called the CRL complex, attaches a molecule called ubiquitin to Perforin-2. Ubiquitin works much like the shipping label of a package, enabling the efficient targeting of Perforin-2 to the invading bacteria. McCormack et al. also show that some bacteria use a protein called a cell cycle inhibiting factor (or Cif for short) to inhibit the CRL complex. This blocks the ubiquitin labeling of Perforin-2, which renders it a useless weapon that can no longer be directed towards bacteria.
Mice that are infected with a bacterium called
Yersinia pseudotuberculosis
become seriously unwell and often die. However, McCormack et al. found that mice infected with mutant
Y. pseudotuberculosis
that lacked Cif remained healthy. Also, mice that lacked Perforin-2 are highly susceptible to infectious diseases. McCormack et al.'s findings reveal how Perforin-2 is activated during the innate immune response and how some bacteria can defeat this pivotal defense. In the current age of antibiotic resistant bacteria, these studies may spur the development of new drugs that restore or increase the activity of Perforin-2.
DOI:
http://dx.doi.org/10.7554/eLife.06505.00
Review of George Eliot in Society: Travels Abroad and Sundays at the Priory
No full textThis is a welcome and wholly worthwhile extension of the author\u27s George Eliot\u27s English Travels: Composite Characters and Coded Communication (2005), a densely written and stimulating examination of places and people in Eliot\u27s life which have some resonance, in varying degrees of coding, from the seemingly casual to the subtly integrated, in her published work. McCormack there defined three categories of place identification. These range from \u27absolute certainties\u27 through \u27pretty good cases\u27 to \u27alluring, probable, but irretrievably speculative suppositions\u27, categories certainly applicable to herpresent study, in which her dedication and saturation in George Eliot, the works, the life, and a wide range of biographical and critical commentary, is again evident. It is a direct invitation to see and feel places and people, decode traits, pick up on similarities, mine differences, above all, be aware. McCormack\u27s method is one of intimate identification with the life and the writing life.
The main thrust demonstrates how Eliot\u27s social agenda, with the Sunday salons from 1869 onwards at the Priory as the focus, feeds into her fiction - and initially her poetry - together with comparable assimilations from her travelling life in Europe with Lewes from 1854 onwards up to the fraught honeymoon with Cross in 1880. Throughout, the Haight contention that Eliot was largely reclusive, a view commonly supported, is subjected to intense scrutiny and is vigorously disputed. The Sunday gatherings, carefully assembled, would suggest that Eliot enjoyed being the centre of a salon of her own making, her essay on Madame de Sable providing precursory evidence. The importance of Lewes as initiator, manager, socializing facilitator with an eye alert as always to publishing and critical opportunities, is integral. McCormack uses his unpublished journals and diaries, supplementing them with a detailed attention to known biographical sources which she carefully sifts for reliability or bias
‘…a tiny part of that greater circum-terrestrial grid’: A Conversation with Mike McCormack
No full textThis is the author accepted manuscript. The final version is available from Edinburgh University Press via the DOI in this recor
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