922 research outputs found
Earthquake and tsunami impact analysis for coastal Lane, Douglas, and Coos counties, Oregon
No full textReport -- Coos Countywide Tables -- Douglas Countywide Tables -- Lane Countywide Tables.by Jonathan C. Allan and Fletcher E. O'Brien.Title from PDF cover (viewed on September 23, 2022)."This report evaluates a Cascadia Subduction Zone earthquake (MW 9.0) and tsunami (M1, L1, and XXL1 scenarios) affecting coastal Lane, Douglas, and Coos counties, Oregon, to understand the degree of potential destruction, including building losses, debris generated, fatalities and injuries, and estimated numbers of the displaced populations. The goal is to help coastal communities prepare for this inevitable disaster"--Page ii.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
The Edwards of History and the Edwards of Faith (Book Review)
No full textBook reviews of books related to evangelist Jonathan Edwards.
Jonathan Edwards and the Bible by Robert E. Brown; Jonathan Edwards: America\u27s Evangelical by Philip F. Gura; Jonathan Edwards at Home and Abroad: Historical Memories, Cultural Movements, Global Horizons by David W. Kling; Douglas A. Sweeney; Jonathan Edwards: A Life by George M. Marsden; Jonathan Edwards\u27s Philosophy of History: The Reenchantment of the World in the Age of Enlightenment by Avihu Zakai; The Works of Jonathan Edwards, Volume 22, Sermons and Discourses, 1739-1742
On the Douglas-Rachford splitting method and the proximal point algorithm for maximal monotone operators
No full textCover title. "This paper consists mainly of dissertation research results of the first author."--Cover.Includes bibliographical references (p. 31-34).Research supported in part by the Army Research Office. DAAL03-86-K-0171 Research supported in part by the National Science Foundation. ECS-8519058by Jonathan Eckstein, Dimitri P. Bertsekas
Corrective justice, harm, and reparations for historical injustice
No full textSome regard harms to currently existing persons as a basis for reparations for historical injustice. By focusing on corrective justice as the basis for repairing wrongful harm, this thesis aims to clarify and strengthen the harm-based approach to reparations. I defend a version of the conformity account as the moral basis of corrective justice, critiquing various versions of this argument by Joseph Raz and John Gardner. I argue that the notion of harm relevant to corrective justice is a counterfactual comparative one and respond to various objections to that conception. I then consider two different cases in which compensation for an historical injustice might be thought appropriate. First, I examine an argument developed independently by Bernard Boxill and George Sher (which I refer to as the chain-harm argument). I analyze Andrew Cohen’s critique of the argument, clarifying the problems it faces before offering some tentative solutions. Second, I examine and critique Judith Jarvis Thomson’s proposal to solve the non-identity problem in the case of the Risky Policy. I explain why her argument fails and offer my own solution.Ph. D.Includes bibliographical referencesby Jonathan Paul Winterbotto
Archaeological reconstruction illustrations: an analysis of the history, development, motivations and current practice of reconstructionil lustration, with recommendations for its future development.
No full textInitially, this study examines how archaeological reconstruction drawing evolved into its present form. Its development within the wider context of social and art history is traced from the 15th to the 201h century, with
particular attention to its various applications, and the motivations for its production. The result is a clearer understanding and definition of the present role and purposes of this branch of illustration. Secondly,the study examines how these purposes are achieved in
contemporary reconstruction artwork. By using an experiment in reconstruction, each component of the process is examined in turn: the design brief,illustrator, illustration and audience. The illustrations produced by the experiment are ranked according to performance, using
the aims of the reconstruction as criteria. Aspects are identified which appear to contribute to good performance,using the information obtained about the illustrations and illustrators. Finally, the results are reviewed as a whole to identify present and possible future trends that may be worth exploring, and to inform a set of proposed guidelines for the commissioning and production of archaeological reconstructions. At present, archaeological reconstruction artwork has received very little academic attention, and there appears to be no formal identification of its aims, agenda or working practice. This study provides the groundwork for rectifying this situation, and supplies new information in several dffferent areas
Lincoln and Douglas: The Debates That Defined America
No full textThose Famous Debates Allen C. Guelzo is the author of several books focusing on Jonathan Edwards and American theology and numerous works on the Civil War era, including Lincoln\u27s Emancipation Proclamation (2004) and Abraham Lincoln: Redeemer President (1999). He combines th...
Signs of Revolt, Truman Brewery, Brick Lane, London
No full textThe author Curated the Signs of Revolt, group show held at Truman Brewery, Brick Lane, London. Other artists, designers, collectives involved included: Kennardphillips, Jonathan Barnbrook, David Gentleman, Pedro Inoue, Jody Boehnart, Ultimate Holding Company, Space Hijackers, Rebel Clown Army, Laboratory of Insurrectionary Imagination, Indymedia, Reel News. Exhbited posters, Hidden Fist, Unfuck The World, Wasteland and Dead End
Inventory for a Reverse Journey. Photographic Image and Found Object - An investigation of travel and material transformation as a paradigm of artist's practice: Ed Ruscha, Douglas Huebler, Bas jan Ader, Jimmie Durham, Gustav Metzger, Kurt Schwitters & Cian Quayle.
No full textInventory for Reverse Journey is the title of a collection of photographic artefacts and found objects, which I have collected over the last twenty years. The title refers to one specific type of artist's journey, which is applicable to the `chronotope' of my archive, as a `metaphorical journey in space and time' (Bakhtin 1981, p. 81). The `city',`provincial town', `road', `threshold' and `interior' are recurrent motifs, which Bakhtin fused together to describe the historical evolution of the novel in relation to its different genres. Bakhtin's motifs are expanded as the basis of an evolutionary nomenclature of the artist's-journey, as a form of spatial mapping and identity formation. Alongside other sources from literature (Alain Robbe-Grillet), cinema (Michelangelo Antonioni), psychoanalysis (Kierkegaard) and critical theory (Walter Benjamin) I have developed a theoretical framework, which initially originated in an empirical process, that is reflected in the antecedents of this project. The research process, as a journey itself, has concretised this approach within a systems-based practice. This is mirrored in the work of the artists under investigation, as their differences and similarities are highlighted within a broad contextual analysis. Accordingly the tone of the writing shifts its register at different points in the thesis.
My journey is just one example of several paradigmatic formations of `travel' as a strategy, which investigates the work of six different artists, as a voluntary or involuntary form of exile. A deskilled use of the photographic image is examined in the work of Ed Ruscha, Douglas Huebler and Bas jan Ader in the spatial mapping of their chosen locations. The work of these artists manifests travel, as a strategy, in a benign form of regional and expatriate exile. The investigation shifts its focus from the New World to Europe, where the work of Jimmie Durham, Gustav Metzger and Kurt Schwitters is analysed in relation to their transformation of found objects and materials, and their relationship with a former 'home'. Their position registers different degrees of the `impossibility of return' to a point of origin, which exists in the mind rather than as a physical location. The transience of their work, and use of disparate materials, is counterbalanced by their physical presence in the work. Conversely Ader, Huebler and Ruscha are linked by a scale of decreasing visibility, as they are sublimated within their work in the formation of, what is now construed as, a unique photographic presence. The starting point for which is a return to the formative years of conceptualism in the 1960's, which set the scene for Durham and Metzger from the 1970's onwards. The spectre of Schwitters practice of forming (Formung) and unforming (Entformung) is significant for my analysis of the dematerialisation of the art-work and artist, by processes of series and repetition, distance and proximity, movement and stasis. Although `travel' is a ubiquitous term, I continue to use it as a portmanteau, which carries with it the themes and `salient' features of a typology of artist's journeys. In a moment of perceived obsolescence as digital information systems engender a culture of `selective-amnesia', these thoughts have informed my work, which runs parallel to the artist case-studies, and the material transformation of the photographic image and found object
Genomics as a tool for natural product structure elucidation
No full textNatural product discovery is in the midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided isolation. This was initially exceptionally productive, yielding the golden age of antibiotics. The fact that a majority of all medicines—especially antibiotics—are in some way derived from or inspired by natural products is a testament to the importance of understanding and harnessing the chemical strategies for biological interaction that have evolved over millions of years. Unfortunately, the overwhelmingly frequent rediscovery rate of known compounds among screened natural extracts meant that what was initially a life-saving torrent of new drugs eventually dried up into a costly trickle. Unfortunately, this has coincided with the rise of drug-resistance superbugs as our initial stockpiles of antibiotics have become overdeployed.
Fortunately, we are now poised to enact an antibiotic renaissance powered by the ease and affordability of large-scale genomic analysis. The ability to genome-gaze has not only revealed hundreds of thousands of yet-untapped secondary metabolites in sequenced organisms but also can facilitate strain prioritization, novelty determination (dereplication), structure elucidation, three principal bottlenecks in the discovery process, as reviewed in Chapter 1. We report here progress in the use of genomics to facilitate the discovery and contextualization of new chemical matter.
In Chapter 2, we report the discovery, isolation, and structural elucidation of streptomonomicin (STM), an antibiotic lasso peptide from Streptomonospora alba, and report the genome for its producing organism. STM-resistant clones of Bacillus anthracis harbor mutations to walR, the gene encoding a response regulator for the only known widely-distributed and essential two-component signal transduction system in Firmicutes. Our results demonstrate that understudied microbes remain fruitful reservoirs for the rapid discovery of novel, bioactive natural product and also highlight the usefulness of genomics in combination with NMR and HR-MS/MS for determining the structure of ribosomal natural products.
In Chapter 3, we use HR-MS/MS, reactivity-based screening, NMR, and bioinformatic analysis to identify Streptomyces varsoviensis as a novel producer of JBIR-100, a fumarate-containing hygrolide. Using a combination of NMR and bioinformatic analysis, we elucidated the stereochemistry of the natural product. We investigated the antimicrobial activity of JBIR-100, with preliminary insight into mode of action indicating that it perturbs the membrane of Bacillus subtilis. S. varsoviensis is known to produce compounds from multiple hygrolide sub-families, namely hygrobafilomycins (JBIR-100 and hygrobafilomycin) and bafilomycins (bafilomycin C1 and D). In light of this, we identified the biosynthetic gene cluster for JBIR-100, which, to our knowledge, represents the first reported for a hygrobafilomycin. Finally, we performed a bioinformatic analysis of the hygrolide family using our RODEO algorithm from Chapter 4, describing clusters from known and predicted producers. Our results indicate that potential remains for the Actinobacteria to yield novel hygrolide congeners and provides a survey of the hygrolide landscape.
In Chapter 4, we report RODEO (Rapid ORF Description and Evaluation Online), an algorithm which combines hidden Markov model-based analysis, heuristic scoring, and machine learning to identify biosynthetic gene clusters and predict RiPP precursor peptides. We initially focused on lasso peptides, which display intriguing physiochemical properties and bioactivities, but their hypervariability renders them challenging prospects for automated mining. Our approach yielded the most comprehensive mapping of lasso peptide space, revealing >1,300 compounds. We characterized the structures and bioactivities of six lasso peptides, prioritized based on predicted structural novelty, including an unprecedented handcuff-like topology and another with a citrulline modification exceptionally rare among bacteria. These combined insights significantly expand the knowledge of lasso peptides, and more broadly, provide a framework for future high-throughput genome mining. In addition to lasso peptides, RODEO provides the ability to analyze local genomic regions using custom profile hidden Markov models (pHMMs) and is suitable for RiPP, polyketide (PKS), nonribosomal peptide (NRPS), and other natural product biosynthetic gene cluster types; as part of an effort to make it available as a community resource we have created a web portal with its code and tutorials.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-12-01The student, Jonathan Tietz, accepted the attached license on 2016-11-28 at 16:51.The student, Jonathan Tietz, submitted this Dissertation for approval on 2016-11-28 at 17:01.This Dissertation was approved for publication on 2016-11-29 at 13:08.DSpace SAF Submission Ingestion Package generated from Vireo submission #10341 on 2017-02-28 at 14:42:14Made available in DSpace on 2017-03-01T17:01:41Z (GMT). No. of bitstreams: 2
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