7,266 research outputs found
Reader, Authors, and the Divine Author: An Evangelical Proposal for Identifying Paul\u27s OT Citations
No full textThe article discusses several approaches for the identification of Old Testament (OT) citations made by Paul. The author-centered approach of Stanley Porter allows the investigation of verbal and thematic parallelism between the Old and the New Testament, while the reader-centered approach of Christopher Stanley, Dietrich-Alex Koch and Richard Hay, considers the impact on the reader. It highlights the method of the Divine Author-centered approach which considers the context of the citation based on the book, the Bible and the canon
The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate
No full textBisphosphonates are the most prescribed preventative treatment for osteoporosis. However, their long-term use has recently been associated with atypical fractures of cortical bone in patients who present with low-energy induced breaks of unclear pathophysiology. The effects of bisphosphonates on the mechanical properties of cortical bone have been exclusively studied under simple, monotonic, quasi-static loading. This study examined the cyclic fatigue properties of bisphosphonate-treated cortical bone at a level in which tissue damage initiates and is accumulated prior to frank fracture in low-energy situations. Physiologically relevant, dynamic, 4-point bending applied to beams (1.5 mm × 0.5 mm × 10 mm) machined from dog rib (n=12/group) demonstrated mechanical failure and micro-architectural features that were dependent on drug dose (3 groups: 0, 0.2, 1.0mg/kg/day; alendronate [ALN] for 3 years) with cortical bone tissue elastic modulus (initial cycles of loading) reduced by 21% (p<0.001) and fatigue life (number of cycles to failure) reduced in a stress-life approach by greater than 3-fold with ALN1.0 (p<0.05). While not affecting the number of osteons, ALN treatment reduced other features associated with bone remodeling, such as the size of osteons (-14%; ALN1.0: 10.5±1.8, VEH: 12.2±1.6, ×10(3) μm2; p<0.01) and the density of osteocyte lacunae (-20%; ALN1.0: 11.4±3.3, VEH: 14.3±3.6, ×10(2) #/mm2; p<0.05). Furthermore, the osteocyte lacunar density was directly proportional to initial elastic modulus when the groups were pooled (R=0.54, p<0.01). These findings suggest that the structural components normally contributing to healthy cortical bone tissue are altered by high-dose ALN treatment and contribute to reduced mechanical properties under cyclic loading conditions.NOTICE: this is the author's version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, Volume 64 (July 2014) DOI: 10.1016/j.bone.2014.03.045Peer reviewe
The historical imagination of Christopher Dawson
No full textChristopher Dawson (1889-1970) was one of his generation's most
important historians and religious thinkers, and was a significant
influence on many contemporaries including T.S. Eliot, C.S. Lewis,
and Russell Kirk. This dissertation is a study of his most
fundamental ideas concerning history and culture.
Chapter one examines Dawson’s sociological view of history.
Convinced that history was more than a scientific enterprise, he
believed that the true historian is one who reaches beyond the
material world to understand the essence of history’s dynamics. In
this way, the world can be conceptualized as a united whole,
separated by regional differences as a result of environment, race,
material, psychological, and religious factors. Dawson believed
that the political histories of the past several centuries failed to
grasp the undercurrents of historical change, and that the best way
to understand the past is to appreciate culture as an expression of
primeval religious traditions.
Chapter two treats Dawson’s understanding of progress. Dawson
was convinced that progress had become the “working-religion” of our
age. This secular faith, founded on scientific rationalism, first
pledged to fix the material failures of Western culture, but
unwittingly eroded its faith in God, and eventually, its moral
fiber. Dawson believed that true progress was progress of the soul
in its ordering toward the Creator.
Chapter three is a study of Dawson’s Christian, and more
specifically, his Catholic beliefs. Informed by religion, his
historical and cultural visions are not dogmatic, nor are they
polemical. He conceived of history as the unfolding of a divine
economy in the temporal world. Although Dawson is a proponent of
Roman Catholicism, his scholarship is an objective treatment of
history shaped by an undisguised, Christian worldview.
Additionally, the appendix is an introduction to Dawson’s life
and the circumstances surrounding his conversion to Roman
Catholicism. Particular attention is paid to the development of his
moral and historical imagination — both of which became intertwined to
form the basis of all of his scholarship
American Society of Biomechanics Journal of Biomechanics Award 2013: Cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures
No full textThe biomechanics literature contains many well-understood mechanisms behind typical fracture types that have important roles in treatment planning. The recent association of "atypical" fractures with long-term use of drugs designed to prevent osteoporosis has renewed interest in the effects of agents on bone tissue-level quality. While this class of fracture was recognized prior to the introduction of the anti-resorptive bisphosphonate drugs and recently likened to stress fractures, the mechanism(s) that lead to atypical fractures have not been definitively identified. Thus, a causal relationship between these drugs and atypical fracture has not been established. Physicians, bioengineers and others interested in the biomechanics of bone are working to improve fracture-prevention diagnostics, and the design of treatments to avoid this serious side-effect in the future. This review examines the mechanisms behind the bone tissue damage that may produce the atypical fracture pattern observed increasingly with long-term bisphosphonate use. Our recent findings and those of others reviewed support that the mechanisms behind normal, healthy excavation and tunnel filling by bone remodeling units within cortical tissue strengthen mechanical integrity. The ability of cortical bone to resist the damage induced during cyclic loading may be altered by the reduced remodeling and increased tissue age resulting from long-term bisphosphonate treatment. Development of assessments for such potential fractures would restore confidence in pharmaceutical treatments that have the potential to spare millions in our aging population from the morbidity and death that often follow bone fracture.Peer reviewe
Published Theologian Joins Bible Faculty
No full textGifted theologian and author Christopher R. Bruno, Ph.D. will join the Cedarville University as assistant professor of Bible and theology in the fall. Bruno previously served as associate vice president for academic administration and assistant professor of biblical studies at Northland International University
Detecting intestinal ischemia using near infrared spectroscopy
No full textBlood supply to the intestine can suddenly be interrupted. Acute mesenteric intestinal ischemia often requires invasive surgery to restore blood supply to the intestine. Early correction of vascular insufficiency is the most important factor in improving patient survival when confronted with acute mesenteric intestinal ischemia. A prolonged loss of blood flow results in irreversible damage to the intestine that can lead to death. It is also imperative that dead segments of the intestines be removed. Several subjective criteria are relied upon to differentiate viable from non-viable tissue, unfortunately, these criteria can lead to an inaccurate assessment. A porcine model of intestinal ischemia was used to determine the efficacy of using near infrared (NIR) spectroscopy to find ischemic segments of the intestine and detect the onset of reperfusion following resolution of vascular occlusion. Nine segments of intestine were identified and six were assigned to three treatment groups; (1) segments undergoing no vascular manipulations, (2) segments undergoing arterial/venous occlusion and (3) segments undergoing arterial/venous occlusion followed by reperfusion. The remaining segments were used as spacers and interposed between each of the ischemia segments. A classification model, using partial least square discriminant analysis, was built on the spectra collected from the segments with no vascular manipulations and the segments that were solely subjected to arterial/venous occlusion. The spectra collected from the intestinal segments that experienced both occlusion and reperfusion were used to test the classification model. The model was able to detect and distinguish ischemic intestinal tissue with a specificity and sensitivity exceeding 80% with an overall classification accuracy of 89%. The method appears to be well suited as an intra-operative assessment method when intestinal ischemia is a concern.Michael G. Sowa, Elicia Kohlenberg, Jeri R. Payette, Lorenzo Leonardi, Michelle A. Levasseur and Christopher B. Rile
The rise of securities markets : what can government do?
No full textUsing U.S. securities markets as a case history, the author explores the role securities markets play in economic development, how they emerge, and how regulation can make them more effective. Why the United States? Two centuries ago, it was a small undeveloped country with serious financial problems. It confronted those problems and, guided by Alexander Hamilton, creatively reformed its financial system, which then became a foundation of the U.S. economic infrastructure and a bulwark for long-term growth. When Hamilton's program established public credit and securitiesmarkets in the 1790s, U.S. citizens were immediately able to borrow from older, richer countries. U.S. wealth then increased until, by the end of the nineteenth century, U.S. residents began to lend and invest more abroad than they borrowed. During the 1820s and 1830s, the United States (usually state governments) borrowed large sums from foreign investors to build roads, canals, and early railroads, to make other transportation improvements, and to capitalize state banks. From the 1830s to the end of the century, still larger sums from overseas went into private U.S. railway companies that provided cheap transcontinental transportation. Most of this borrowing took the form of state and corporate bond sales to overseas investors. The pristine U.S. government credit established by Hamilton thus rubbed off on U.S. state and corporate debt. The British stock market did better than the U.S. market until the United States adopted security-market regulation (including disclosuire rules) under the SEC. Then the U.S. market became a world leader. The U.S. stock market developed more slowly than the bond market, but it both aided and benefited from foreign investment in U.S. bonds. Foreign investors preferred debt securities to equities, yet equities create a safety margin for bondholders who, because of this margin, are more willing to purchase and hold bonds. Foreign investors preferred bonds; U.S. investors, after exporting bonds, held more stocks than bonds at home. Why? Because good stock markets permit the conversion of equity securities into cash.Environmental Economics&Policies,Payment Systems&Infrastructure,Financial Intermediation,International Terrorism&Counterterrorism,Economic Theory&Research,Housing Finance,Insurance&Risk Mitigation,Financial Intermediation,Environmental Economics&Policies,Economic Theory&Research
Studien zu Gregor von Nyssa und der christlichen Spätantike /
No full textIncludes bibliographical references (p. [382]-391) and index.Michel Van Esbroeck -- Martin F.G. Parmentier -- Everett Ferguson -- Manfred Kertsch -- Martin Esper -- Alden A. Mosshammer -- Anthony Meredith -- G. Christopher Stead -- Bruno Salmona -- Lucas F. Mateo-Seco -- Alberto Viciano -- Lionel R. Wickham -- Reinhard Kees -- Jesus Sancho Bielsa -- Marek Starowieyski -- Juan Luis Bastero -- Hubertus R. Drobner -- Jose Luis Illanes -- Jurgen Blansdorf -- Georg Luck -- Udo Reinhardt
The Asia-Pacific Clinical Practice Guidelines for the management of frailty
No full textAbstract not availableElsa Dent, Christopher Lien, Wee Shiong Lim, Wei Chin Wong, Chek Hooi Wong, Tze Pin Ng, Jean Woo, Birong Dong, Shelley de la Vega, Philip Jun Hua Poi, Shahrul Bahyah Binti Kamaruzzaman, Chang Won, Liang-Kung Chen, Kenneth Rockwood, Hidenori Arai, Leocadio Rodriguez-Mañas, Li Cao, Matteo Cesari, Piu Chan, Edward Leung , Francesco Landi, Linda P. Fried, John E. Morley, Bruno Vellas, Leon Flicke
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