4,078 research outputs found
UT Tyler Patriot Vol. 21 no. 2
No full textThe official newspaper for the University of Texas at Tyler from 1979 to 1993. Articles in this issue include: We Must Never Stop Trying to Find Peaceful Solutions -Eban; Caddy Shack Home for Graduate Student; Safe-D Promotes Safety, Auto Accidents Curbed; Highest Fall Enrollment Totals 4101 at UT Tyler; Stones Tickets Still Available; Campus Organizations Co-Sponsor Student/Faculty Reception Oct. 17; Think Again; There\u27s No Such Thing as a Little Freedom; Poll Reflects Optimism; The SA Beat; Registration Deadline Nears for Nov. 7 City, State Elections; UTT Drama Production Dining Room Opens Oct. 27; Dr. George Feifer Noted Author Explains Russian Life; Professor, Son Spend Year in Sister City ; Counseling Center Offers a Variety of Services; Kidd, Fitzgerald Win; SIFE Students Meet Saturday; Tennis Team Wins Championshiphttps://scholarworks.uttyler.edu/uttylerpatriot/1131/thumbnail.jp
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage
No full textOxidative damage to nuclear DNA is known to involve site-specific Fenton-type chemistry catalysed by redox-active iron or copper in the immediate vicinity of DNA. However, the presence of transition metals in the nucleus has not been shown convincingly. Recently, it was proposed that a major part of the cellular pool of loose iron is confined within the acidic vacuolar compartment [Yu, Persson, Eaton and Brunk (2003) Free Radical Biol. Med. 34, 1243-1252; Persson, Yu, Tirosh, Eaton and Brunk (2003) Free Radical Biol. Med. 34, 1295-1305]. Consequently, rupture of secondary lysosomes, as well as subsequent relocation of labile iron to the nucleus, could be an important intermediary step in the generation of oxidative damage to DNA. To test this concept we employed the potent iron chelator DFO (desferrioxamine) conjugated with starch to form an HMM-DFO (high-molecular-mass DFO complex). The HMM-DFO complex will enter cells only via fluid-phase endocytosis and remain within the acidic vacuolar compartment, thereby chelating redox-active iron exclusively inside the endosomal/lysosomal compartment. Both free DFO and HMM-DFO equally protected lysosomal-membrane integrity against H2O 2-induced oxidative disruption. More importantly, both forms of DFO prevented H2O2-induced strand breaks in nuclear DNA, including telomeres. To exclude the possibility that lysosomal hydrolases, rather than iron, caused the observed DNA damage, limited lysosomal rupture was induced using the lysosomotropic detergent O-methyl-serine dodecylamine hydrochloride; subsequently, hardly any DNA damage was found. These observations suggest that rapid oxidative damage to cellular DNA is minimal in the absence of redox-active iron and that oxidant-mediated DNA damage, observed in normal cells, is mainly derived from intralysosomal iron translocated to the nucleus after lysosomal rupture
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No. 18 Fall/Winter 2014 Newsletter
No full textHaricombe Takes Over
Modern Space for Modern Students
Center for Verse Opens
Pre-Mod, Pre-Med
The Libraries' Closet
Distinguished Author Dinner Recap
Interview with Cale McDowell
Campaign for Texas Wrapup
New Media Labs Open at PCL, FALUT Librarie
Copyright Issues Got You Down?: Updates from the Scholarly Communications Working Group
No full textThe use and creating of research are integral parts of faculty’s teaching and scholarship, but navigating the ins and outs of copyright issues, the allowances and exclusions, can be overwhelming. During this workshop, participants will hear about what UT Tyler’s Scholarly Communications working group has developed for faculty, including information relating to author rights, copyright, fair use, open access, creating access to faculty scholarship through Scholar Works at UT Tyler, and the use of open textbooks and other free course materials
Intercom 1995 November 27
No full textCampus Campaign Exceeds Goal, UT Tyler, TJC Music Groups to Perform, Repertory Plays Scheduled in December, Graduate Students Author AmeriCorps Grant, In The Spotlight, Alphi Chi Names Outstanding Faculty, Personnel Update, Service Recognition, Christmas Holiday Schedule
UT Tyler Patriot Vol. 22 no. 5
No full textThe official newspaper for the University of Texas at Tyler before it was changed to the Patriot Talon. Articles in this issue include: Computer\u27s Recovering from Viral Infection; Pace Releasing Potential ; 5K Run Kicks off Eisenhower; SA Announces Student Elections; Ramirez to Address Student Rights Tonight; Computer Virus Strikes at N.C. State University; Author Tom Wolfe Concludes Distinguished Lecture Series; Use Safe Software; Little Girls Should Romp ; Aggies Make Friends, Learn New Recipes; The SA Beat; Real Issues are Scarce in Governor\u27s Race; Nursing Student Chosen to Attend Summer International Conferences; College Board\u27s Aid Applications Backlogged; \u27Shirtspeak\u27 Means Spring has Arrived; Newspaper\u27s Publication Suspended by University\u27s Student Government; 2.2 Mile \u27Poker\u27 Fun Walk/Jog/Run; Final Exam Schedule; Anti-Apartheid Students Active in Demonstrations; Sex Survey Reveals Male, Female Students Lie; Female Sex Habits Persist; Ford Tags 700 snakes; National College Endowment Report; Today\u27s Teenage Males not Sexual Adventurershttps://scholarworks.uttyler.edu/uttylerpatriot/1140/thumbnail.jp
Subscription, Interlibrary Loan, or Nothing: How to Ensure Global Access to Your Scholarly Works
No full textPublishing through traditional journals often limits access to your scholarship — researchers can only read your works through a journal subscription, via available library databases, interlibrary loan, or pay the publisher for access. This workshop will show how faculty can use Scholar Works at UT Tyler to store, preserve and provide worldwide access to their scholarly output. A discussion about open access, including: copyright agreements, author rights, avoiding predatory journals, and benefits of adding content to Scholar Works at UT Tyler. Bring your CV and we can review specific copyright policies of your published works
Forum vol. 14 no. 1
No full textPresident\u27s Podium Dr. George F. Hamm, Jack Blanton Elected Chairman at UT Tyler Meeting, Ratliff, Roden Named Vice Chairmen, Life in Foreign Lands UT Tyler Graduates Share Experiences, Distinguished Student, Alumni Notes, Alumni Introduce New Liaison, Former All-American Leads Fun Run, Alumni Association Life Member, Alumni Board Elected, University Receives Major Gifts, Nancy Lake, Mattie Alice Scroggin Baker, Kissinger Opens Lecture Series, John Palmer, Dr. Elizabeth Dunn Educator, Author, Film Critic, Faculty Profile, Glenn Named Amoco Recipient, One Minute Manager Highlights Series, Stanley Chosen Piper Nominee, Faculty Focus, And Now Veterinary Medicine, 1987 Spring Graduates, 1986 Fall Graduates, PTK Bestows UT Tyler Three Awards, Who\u27s Who Students Announced, Academic All-Americans, National Higher Education Week, King Scholarship Recipient
The UT Tyler Patriot Vol. 14 no. 6
No full textThe official newspaper for the University of Texas at Tyler from 1979 to 1993. Articles in this issue include: Lecture Series Hosts Mexican Author; Computer Aids Skill in Job-Interviewing; Continuing Education Gets Local Help; Campus Police Seek Help, Warn Students; State Declares April 21 Holiday; Teachers Prepare for EXCET Test; Springfest Offers Annual Festivities to Welcome Summer Relaxation; Student Life Reveals Past; Students Squeeze Into Summer; Security Guard Honors Two Texas Birthdays; Israeli Professor Visits Campus; Please Louise; ACM Gives Computer Help; Registrar\u27s Assistant Sends Students Away With a Smile; Patriot Profile; Accounting Major is Honored; Learning Lab Moves; ACS Holds Magic Show; TECAT Examinations Help Point Out Pluses and Minuses for State Teachers; Firing Line; Oil Palace Less than \u27Fabulous\u27; Women\u27s Tennis Unbeaten with Three Matches to be Played; Men\u27s Tennis Team Qualifies to Play National Tournamenthttps://scholarworks.uttyler.edu/uttylerpatriot/1091/thumbnail.jp
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