44 research outputs found
Persistence of Ebola virus in ocular fluid during convalescence
No full textPlease note: A correction to the original article has been published. “From New England Journal of Medicine, Jay B. Varkey,
Jessica G. Shantha, Ian Crozier, Colleen S. Kraft, G.
Marshall Lyon, Aneesh K. Mehta, Gokul Kumar, Justine
R. Smith, Markus H. Kainulainen, Shannon Whitmer,
Ute Ströher, Timothy M. Uyeki, Bruce S. Ribner, and
Steven Yeh, Persistence of Ebola Virus in Ocular Fluid
during Convalescence, 2015; 372:2423-2427. Copyright © (2015) Massachusetts Medical Society. Reprinted with permission.Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.Supported by a grant from the National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR000454, to the Atlanta Clinical and Translational Science Institute), an unrestricted grant from Research to Prevent Blindness and a grant from the National Eye Institute (P30-EY06360, to the Department of Ophthalmology, Emory University School of Medicine), and a fellowship grant from the Australian Research Council (FT130101648, to Dr. Smith). Favipiravir was provided by the Department of Defense Joint Project Manager Medical Countermeasure Systems
