3,717 research outputs found
Coralie Cain among the vines, Waikerie, South Australia, ca. 1973 [picture] /
No full textAfter her husband and a daughter were killed in 1970, Coralie ran their wine grapes and apricots block alone.; Part of: Sheilas, a tribute to Australian women collection, ca. 1975.; Condition: Good.; Title devised by cataloguer based on information supplied by photographer.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4227461; Published in : Sheilas : a tribute to Australian women by John Larkins and Bruce Howard. Adelaide : Rigby, 1976, p.224
Coralie Cain, Waikerie, South Australia, ca. 1973 [picture] /
No full textAfter her husband and a daughter were killed in 1970, Coralie ran their wine grapes and apricots block alone.; Part of: Sheilas, a tribute to Australian women collection, ca. 1975.; Title devised by cataloguer based on information supplied by photographer.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4227460; Published in : Sheilas : a tribute to Australian women by John Larkins and Bruce Howard. Adelaide : Rigby, 1976, p.222
New results on the genetic cryptanalysis of TEA and reduced-round versions of XTEA
No full textCongress on Evolutionary Computation. Portland, USA, 19-23 June 2004Recently, a simple way of creating very efficient distinguishers for cryptographic primitives such as block ciphers or hash functions, was presented by the authors. Here, this cryptanalysis attack is shown to be successful when applied over reduced round versions of the block cipher XTEA. Additionally, a variant of this genetic attack is introduced and its results over TEA shown to be the most powerful published to date
Consumer Demand and Welfare under Increasing Block Pricing
No full textThis paper argues that an increasing block pricing structure needs to be supplemented by allowances for household size and composition to be equitable. Household behaviour is modelled as the outcome of a two-stage budgeting resulting in an integrable water demand model. The welfare effects of block pricing are studied using the concept of relative equivalence scale, modified to allow for the dependence of price on household size and composition. We use individual household data to estimate residential demand for water, provide empirical illustration of the welfare effects of increasing block pricing on demographically different households and show how these effects can be compensated.relative equivalence scales, price endogeneity, demand for water
A Block ILUT Smoother for Multipatch Geometries in Isogeometric Analysis
No full textSince its introduction in [20], Isogeometric Analysis (IgA) has established itself as a viable alternative to the Finite Element Method (FEM). Solving the resulting linear systems of equations efficiently remains, however, challenging when high-order B-spline basis functions of order p> 1 are adopted for approximation. The use of Incomplete LU (ILU) type factorizations, like ILU(k) or ILUT, as a preconditioner within a Krylov method or as a smoother within a multigrid method is very effective, but costly [37]. In this paper, we investigate the use of a block ILUT smoother within a p-multigrid method, where the coarse grid correction is obtained at p= 1, and compare it to a global ILUT smoother in case of multipatch geometries. A spectral analysis indicates that the use of the block ILUT smoother improves the overall convergence rate of the resulting p-multigrid method. Numerical results, obtained for a variety of two dimensional benchmark problems, illustrate the potential of this block ILUT smoother for multipatch geometries.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Numerical Analysi
Block ILU smoothers for p-multigrid methods in Isogeometric Analysis
No full textIsogeometric Analysis (IgA) is an extension of the more well known Finite Element Method (FEM). It allows for more accurate descriptions of boundary value problems on irregular domains. However, many of the traditional iterative solution strategies that are known to work well in FEM do not show the same behavior in IgA, especially for increasing order of basis functions p.A method shown to have fast convergence in this situation is a p-multigrid method with a smoother based on a Block ILUT factorization. Most of the blocks of this factorization are efficiently calculated. The same holds for the smoothing steps. It is therefore our objective to make changes to the Block ILUT smoother. Inspiration is taken from methods where ILU factorizations are constructed using a fixed-point iteration. We combine these with the existing Block ILUT smoother.This ultimately leads to two new proposed methods we will call Block Fixed-point ILU and Block ParILUT.The existing methods as well as the newly suggested methods are tested and compared on computational costs of the factorization, the number of nonzero entries in this factorization and the number of multigrid iterations neededto reach convergence, if these factorizations are to be used as smoother. The benchmark used for these tests is a convection diffusion reaction (CDR) equation on a multipatch geometry with 4, 16 or 64 patches.Applied Mathematic
A survey of blockholders and corporate control
No full textThe author surveys the empirical literature on large-percentage shareholders in public corporations, focusing on four key issues: the prevalence of blockholders; the motivation for block ownership; the effect of blockholders on executive compensation, leverage, the incidence of takeovers, and a wide range of corporate decisions; and the effect of blockholders on firm value. A central finding of this study is that there is little reason for policymakers or small investors to fear large-percentage shareholders in general, especially when the blockholders are active in firm management.Stockholders ; Corporate governance
BRUCE depletion induces autophagy via the AMPK-ULK1 mediated activation of the autophagy axis.
No full text(A) U2OS-shBRUCE-GFP-LC3 cells were treated with or without DOX. CQ (50 μM, 2 hr) was then added to block lysosome fusion. Cell lysates were immunoblotted with antibodies as indicated. (B and C) Immunoblot results with multiple replicates were quantified for pULK1 (B) and pAMPK (C). *, p<0.05. (D) U2OS cells treated with siBRUCE #2 to knockdown BRUCE expression were immunoblotted with indicated antibodies. (E) Rescue experiments in U2OS-shBRUCE cells reconstituted with a siBRUCE-resistant FLAG-BRUCE (+DOX; +WT), with the cell lysates immunoblotted with indicated antibodies. (F) Cell lysates were assayed for the ratio of AMP/ATP and mean fold change was compared in control (-DOX) and BRUCE KD (+DOX) cells. Control was normalized as 1. Three independent experiments. *, p<0.05. (G) A working model showing a BRUCE-AMPK-ULK1 axis in the regulation of energy metabolism and autophagy.</p
Two-Sample Testing in High Dimension and a Smooth Block Bootstrap for Time Series
No full textThis document contains three sections. The first two present new methods for two-sample testing where there are many variables of interest and the third presents a new methodology for time series bootstrapping.
In the first section we develop a test statistic for testing the equality of two population mean vectors in the "large-p-small-n" setting. Such a test must surmount the rank-deficiency of the sample covariance matrix, which breaks down the classic Hotelling T^(2) test. The proposed procedure, called the generalized component test, avoids full estimation of the covariance matrix by assuming that the p components admit a logical ordering such that the dependence between components is related to their displacement. The test is shown to be competitive with other recently developed methods under ARMA and long-range dependence structures and to achieve superior power for heavy-tailed data. The test does not assume equality of covariance matrices between the two populations, is robust to heteroscedasticity in the component variances, and requires very little computation time, which allows its use in settings with very large p. An analysis of mitochondrial calcium concentration in mouse cardiac muscles over time and of copy number variations in a glioblastoma multiforme data set from The Cancer Genome Atlas are carried out to illustrate the test.
In the second section we present a theorem establishing a power improvement to the Benjamini-Hochberg procedure for controlling the false discovery rate when it is applied to test statistics which have been adjusted for the effects of latent factors. We extend recently published methodology to the context of serially dependent test statistics by presenting a frequency-domain adaptation of their procedure. We show that our harmonic factor adjustment to the test statistics improves the power of the Benjamini-Hochberg procedure without compromising its control of the false discovery rate when the test statistics are affected by latent periodic components. An illustration of our methodology is given in an analysis of copy number variations, which are measured along a chromosome and tend to exhibit serial dependence; power gains from our harmonic factor adjustment are demonstrated.
In the third section we present a smoothed bootstrap procedure for time series data. Unlike with independent data, smoothed boostraps have received little consideration for time series. However, as evidenced in the iid smooth bootstrap, additional data smoothing steps within resampling can improve bootstrap approximations of the distributions of statistics, especially when such sampling distributions depend critically on unknown and smooth (e.g., infinite-dimensional) population quantities, such as marginal densities. To broaden the effectiveness of the bootstrap for time series, we propose a smooth bootstrap based on modifying a state-of-the-art block resampling approach for dependent data based on tapering windows. The resulting smooth (extended) tapered block bootstrap
(TBB) is shown to provide valid variance and distributional approximations over a broad class of parameters and statistics for stationary time series, formulated in terms of statistical functionals (e.g., smooth function model statistics, L- and M-estimators, rank statistics). Our treatment goes beyond statistics as smooth functions of sample averages, showing that the smooth TBB has applicability in inference cases which have not been formally established for other TBB versions. Some finite-sample simulations also provide evidence that smoothing steps enhance the performance of the block bootstrap for various statistical functionals
LC3 turnover assay showing an elevated autophagy activity induced by BRUCE depletion.
No full text(A) U2OS-shBRUCE-GFP-LC3 cells (clone #16, maintained in complete medium) were left untreated or treated with DOX to induce knockdown of BRUCE expression, followed by immunostaining with a LC3B antibody (green) and counter stained with DAPI (blue), Bar: 20 μm. (B) Semi-quantification of LC3B puncta numbers (immunofluorescent puncta) in each cell. *, p<0.05. (C) U2OS-shBRUCE-GFP-LC3 cells were transfected with control (siCtrl) and two distinct siRNAs targeting BRUCE (siBRUCE#2 and siBRUCE#3). LC3B puncta were immunostained and the results were quantified in (D). *, p<0.05. Bar: 10 μm. (E) BRUCE knockdown was performed with lentivirus mediated shRNAs (shScramble and shBRUCE) in starved human liver cell line THLE2. LC3B puncta were immunostained and the results were quantified (F). *, p<0.05. Bar: 20 μm. (G) DOX treated U2OS-shBRUCE-GFP-LC3 cells were incubated with CQ (50 μM, 2 hr) to block lysosome fusion and the total cell lysates were immunoblotted with indicated antibodies.</p
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