135,999 research outputs found
A human factor-dependent cell line stimulates cobblestone formation under human bone marrow stromal cells in vitro
No full textMUTATED RECOMBINANT HUMAN HEAVY-CHAIN FERRITINS AND MYELOSUPPRESSION INVITRO AND INVIVO - A LINK BETWEEN FERRITIN FERROXIDASE ACTIVITY AND BIOLOGICAL FUNCTION
No full textEffects of retroviral mediated gene transfer of the IL3, GM-CSF, and Flt3-Ligand and its two isoforms genes into primary stromal cells on the activity of umbilical cord blood CD34++ progenitor cells in long term culture.
No full textProtecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
Investigation of Lagrangian coherent structures in a wake-induced boundary layer transition
No full textThe evolution of coherent structures in a flat plate boundary layer transition induced by the cylinder wake is investigated using the particle image velocimetry (PIV) technique. The finite-time Lyapunov exponent (FTLE), which characterizes the amount of stretching about the flow trajectory, is used to extract the Lagrangian coherent structures. It is revealed that secondary vortex is induced by the cylinder wake vortices in the near wall region,which would evolve into hairpin vortex as it convects downstream. The subsequent evolvement of the hairpin vortex, characterized by the regeneration of offspring hairpin vortex upstream of it, leads to the appearance of the hairpin packet and the boundary layer finally reaches a turbulent state
Taxonomy and nomenclature of Salix baileyi, S. rehderiana, and S. disperma
No full textResearchers have frequently misapplied the name Salix leveilleana C.K. Schneider to S. baileyi C.K. Schneider. After detailed study of the types, relevant specimens and literature, S. leveilleana is synonymized with S. disperma Roxb. ex D. Don. Salix dolia C.K. Schneider and S. rehderiana C.K. Schneider represent the same taxon; in this study, the later one is chosen. Furthermore, the author perfected the descriptions of S. baileyi, and amend its distribution area to include Hunan and Zhejiang, China.</jats:p
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
The Göttingen rotating turbulent Rayleigh-Bénard convection facility
No full textThermally driven turbulent convection under the influence of global rotation is ubiquitous in nature. Well known examples are the outer convective shell of our Sun and the outer liquid core of the Earth. Trying to understand the underlying dynamics of such flows is highly challenging, not only because of the enormous range in length- and time-scales that are involved with these geo/astrophysical cases and the complex interaction of hydrodynamics with electromagnetism, but also because direct measurements on these systems are most often impossible to carry out. We gain access to direct measurements by isolating part of the problem: We focus solely on the hydrodynamical aspects of turbulent convection by performing experiments in the lab and making comparisons with direct numerical simulations (DNS). The canonical system that we use to study such flows is Rayleigh-B\'enard convection (RBC), the flow between a warm bottom plate and cold top plate, in a fluid-filled upright cylindrical cell that is rotating around its geometrical axis. This presentation will focus on the newly constructed rotating RBC facility at the Max Planck Institute for Dynamics and Self-Organization (MPIDS) in G\"ottingen
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