336,996 research outputs found
The Role of the Sympathetic Nervous System in the Hypothermic Effect of d-Fenfluramine
No full textExperiments in this dissertation were conducted to characterize the effects of d-fenfluramine on body temperature and the mechanisms by which d-fenfluramine alter body temperature. The experiments were conducted in conscious male Sprague-Dawley rats. Body temperature was measured in all animals using telemetry. The results of the experiments indicated that d-fenfluramine altered body temperature in animals kept 28, 22, 16 and 4 degrees Centigrade. D-fenfluramine produced hyperthermia in animals kept at 28 degrees Centigrade and varying degrees hypothermia at normal and cooler ambient temperatures. Further experiments were conducted to explore the effects of d-fenfluramine on brown adipose tissue (BAT) thermogenesis, cutaneous vascular tone and whole body oxygen consumption. In animals kept at 22 and 4 degrees Centigrade, we found that d-fenfluramine activated BAT, as indicated by a decrease in BAT norepinephrine content, to the same magnitude. Thus, the hypothermia seen at normal and cooler ambient temperature was not due to lack of BAT activation. Also, activation of BAT by d-fenfluramine was mediated through the sympathetic nervous system and through release of central serotonin, since ganglionic blocker pentolinium and serotonin reuptake inhibitor fluoxetine blocked d-fenfluramine-mediated BAT activation. In animals kept at 16 degrees Centigrade, d-fenfluramine increased tail-skin temperature (Tsk), an index of cutaneous vascular tone, indicating that d-fenfluramine produced cutaneous vasodilation. d-fenfluramine-induced increase in Tsk was mediated through withdrawal of the sympathetic vasoconstrictor tone to the tail, since pentolinium blocks this effect. In animals kept at 28 degrees Centigrade, d-fenfluramine produced a decrease in Tsk, indicating vasoconstriction. The effects of d-fenfluramine on the Tsk were mediated through release of serotonin, since fluoxetine blocked these effects. D-fenfluramine increased whole body oxygen consumption, an index of metabolic activity and the increase was due to BAT activation, since pentolinium prevented the increase. Thus, although d-fenfluramine increased metabolic activity through BAT activation, the increase was insufficient to make up for the heat loss produced by cutaneous vasodilation and thus produces hypothermia. The hyperthermia seen at 28oC is due to activation of BAT and the subsequent inability of the animal to lose the excess heat due to cutaneous vasoconstriction produced by d-fenfluramine at 28 degrees Centigrade
Chemometric Software supporting NSF Project Variable Selection for Remedying the Effects of Uncontrolled Variation in Data Driven Predictions
No full textSoftware is provided as a deliverable product for NSF project Variable Selection for Remedying the Effects of Uncontrolled Variation in Data Driven Predictions (NSF Grant Number 1506853). There are 8 separate software packages, each provided in its own folder. Each folder includes a README file and example data to permit testing. The packages implement work published in the following papers:D. Poerio and S.D. Brown, “Stacked Interval Sparse Partial Least Squares Regression Analysis,” Chemom. Intell. Lab Syst. 166, 2017, 49-60. (DOI: 10.1016/j.chemolab.2017.03.006)D. Poerio and S.D. Brown, “Dual-Domain Calibration Transfer by Orthogonal Projection” , Appl. Spectrosc., 2018. (DOI: 10.1177/0003702817724164).Erratum to Dual-domain calibration transfer using orthogonal projection. Appl. Spectrosc. 2018, (DOI: 10.1177/0003702818768732)D. Poerio and S.D. Brown, A Frequency-Localized Recursive Partial Least Squares Ensemble for Soft Sensing, J. Chemom. e2999, 2018. (DOI: 10.1002/cem.2999)D. Poerio and S.D. Brown, “Highly-Overlapped, Recursive Partial Least Squares Soft Sensor with State Partitioning via Local Variable Selection”,Chemom. Intell. Lab Syst. 175 (2018) 104–115. (DOI: 10.1016/j.chemolab.2018.02.006)C. Kneale and S.D. Brown, “Small Moving-Window Calibration Models for Soft Sensing Processes with Limited History.” Chemom. Intell. Lab. Syst.183, 2018, 36-46. (DOI: 10.1016/j.chemolab.2018.10.007)C. Kneale and S.D. Brown, Band Target Entropy Minimization and Target Partial Least Squares for Spectral Recovery and Calibration, Analyt. Chim. Acta, 1031 (2018) 38-46. (DOI:10.1016/j.aca.2018.07.054)D. Poerio and S.D. Brown, Localized and Adaptive Soft Sensor Based on an Extreme Learning Machine with Automated Self-correction Strategies, J. Chemom., 2018;e3088. (DOI: 10.1002/cem.3088)C. Kneale and S.D. Brown, Exploratory Data Analysis using an Uncharted Forest, Talanta 189 (2018) 71–78. (DOI: 10.1016/j.talanta.2018.06.061)NSF Grant Number 150685
Morgan D. Brown Civil War materials
No full textThis collection contains transcribed typescript copies as well as photocopies of personal and official correspondence relating to Brown's Confederate military service
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
Double nine patch quilt by Eunice Ann Brown Munk
No full textImage of Double Nine Patch quilt created in 1879 by Eunice Ann Brown Munk. Also includes questionnaires describing the quilt completed by Ruth D. Scow as part of the Utah Quilt Guild\u27s documentation days held from 1988-1994. This quilt received the USU Antique Quilt Award in 198
Letter from D. J. Brown to Oscar Monnig (June 10, 1964)
No full textLetter from D. J. Brown (on behalf of Parry, Leon, and Hayhoe Ltd.) to Oscar Monnig stating that the Export Department has spoken with the Stores Department and has confirmed the weight of the Gibeon meteorite specimen drum
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