1,722,884 research outputs found
Publication article K. Brosens et G. Delmarcel
No full textKoenraad Brosens and Guy Delmarcel, "Raphael’s ‘Acts of the Apostles’: Italians in the service of the Habsburg monarchy and the Leyniers tapestry workshop, 1725-55", The Burlington Magazine, CLVI, June 2014, pp. 376-381
Data for: Slope gradient controls soil thickness and chemical weathering in subtropical Brazil: understanding rates and timescales of regional soilscape evolution through a combination of field data and modeling
No full textThis data repository contains 3 main files: 1) Excel tables with: - Input and results of the synthetic model runs (Table S3) - Input and results of model applied to sampling locations (Table S4) - Soil profile description for each sampled location 2) Map with the coordinates of the sampling locations (.gpx and .shp format) 3) Text file containing the spectra of the scanned regional samples in the Mid- Infrared region (MIR). Spectra are given as absorbance and already corrected for possible drift by dividing by the background sample
Data for: Combination of numerical modelling and field measurments reveals strong regional control of slope on soil thickness and chemical weathering in subtropical Brazil
No full textThis data repository contains 3 main files:
1) Excel tables with:
- Input and results of the synthetic model runs (Table S3)
- Input and results of model applied to sampling locations (Table S4)
- Soil profile description for each sampled location
2) Map with the coordinates of the sampling locations (.gpx and .shp format)
3) Text file containing the spectra of the scanned regional samples in the Mid-
Infrared region (MIR). Spectra are given as absorbance and already corrected for
possible drift by dividing by the background sample
Progesterone action in the myometrium and decidua in preterm birth
Get PDFProgesterone is central to many reproductive processes and is critical in regulating the menstrual cycle and maintaining pregnancy. We discuss here similarities in the molecular mechanisms that regulate the process of decidualisation in endometrial stromal cells and uterine quiescence in myometrial smooth muscle cells. We discuss recent evidence that the decidua may be an important mediator of progesterone actions in the onset of labor in mammalian species lacking progesterone withdrawal. These observations have relevance to recent clinical observations of the effect of progesterone administration in the prevention of preterm labor. We suggest that further research is required to understand the role of progesterone in maintaining the decidua in late pregnancy and particular focus should be given to the mechanisms that increase prostaglandin production in the uterus at term
The human endometrium as a sensor of embryo quality
No full textHuman reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed
Recensione di La quinta stagione di P. Brosens e J. Woodworth
No full textLa recensione considera "La quinta stagione" in relazione alle precedenti opere di Brosens e Woodworth, individuandone i temi ricorrenti. La recensione mette in luce il carattere pessimistico della visione della condizione umana che è alla base del film
Uterine fibroids: an update on current and emerging medical treatment options
Get PDFManuela Farris,1,2 Carlo Bastianelli,1 Elena Rosato,1 Ivo Brosens,3 Giuseppe Benagiano1 1Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy; 2The Italian Association for Demographic Education, Rome, Italy; 3Faculty of Medicine, KU Leuven, Leuven, Belgium Abstract: Uterine fibroids are the most common gynecological disorder, classically requiring surgery when symptomatic. Although attempts at finding a nonsurgical cure date back to centuries, it is only around the middle of the last century that serious attempts at a medical treatment were carried out. Initially, both progestins and estrogen–progestin combinations have been utilized, although proof of their usefulness is lacking. A major step forward was achieved when peptide analogs of the GnRH were introduced, first those with superagonist properties and subsequently those acting as antagonists. Initially, the latter produced side effects preventing their routine utilization; eventually, this problem was overcome following the synthesis of cetrorelix. Because both types of analogs produce hypoestrogenism, their use is limited to a maximum of 6 months and, for this reason, today they are utilized as an adjuvant treatment before surgery with overall good results. Over the last decade, new, nonpeptidic, orally active GnRH-receptor blockers have also been synthesized. One of them, Elagolix, is in the early stages of testing in women with fibroids. Another fundamental development has been the utilization of the so-called selective progesterone receptor modulators, sometimes referred to as “antiprogestins”. The first such compound to be applied to the long-term treatment of fibroids was Mifepristone; today, this compound is mostly used outside of Western Countries, where the substance of choice is Ulipristal acetate. Large clinical trials have proven the effectiveness of Ulipristal in the long-term medical therapy of fibroids, although some caution must be exercised because of the rare occurrence of liver complications. All selective progesterone receptor modulators produce unique endometrial changes that are today considered benign, reversible, and without negative consequences. In conclusion, long-term medical treatment of fibroids seems possible today, especially in premenopausal women. Keywords: uterine myomas, progestin, gonadotropin-releasing hormone receptor blockers, selective progesterone receptor modulators, antiestrogen
- …
