313 research outputs found
Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by the nuclease activity of EXD2
No full textRaw data for the manuscript entitled “Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by the nuclease activity of EXD2”
Actin nucleators safeguard replication forks by limiting nascent strand degradation
No full textRaw imaging files (representative) and source data for the manuscript 'Actin nucleators safeguard replication forks by limiting nascent strand degradation' Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, Joanna Krwawicz, Alexandra Kanellou, Camelia Mocanu, Vicky Bousgouni, Charlotte Smith, Kuo-Kuang Wen, Beth L. Woodward, Chris Bakal, Fiona Shackley, Andres Aguilera, Grant S. Stewart, Yatin M. Vyas and Wojciech Niedzwiedz </p
Grandchildren of the revolution : sexuality, nation and Frank Ronan
Full text linkMestrado em Estudos InglesesEsta tese propõe-se a investigar expressões do discurso gay irlandês
contemporâneo na obra do autor irlandês Frank Ronan. O tratamento literário
de temas como a influência da Igreja Católica, a importância da célula familiar
irlandesa, ou a manifestação de posições políticas relacionadas com
nacionalismo e colonialismo nas suas obras será analisado, com vista a
examinar como estes e outros factores moldam a maneira como o discurso
homossexual é construído na república da Irlanda e no trabalho de Frank
Ronan em particular. Também será dada atenção a estereótipos nacionais e o
seu efeito na escrita de Frank Ronan.
ABSTRACT: This dissertation proposes an investigation of expressions of the contemporary
Irish gay discourse in the fiction of Irish author Frank Ronan. The literary
treatment of themes such as the influence of the Catholic Church, the
importance of the Irish family cell, or the manifestation of political views,
concerning nationalism and colonialism in the novels will be analysed, in order
to study how these and other factors shape the way that homosexual discourse
is constructed in the Republic of Ireland and in the work of Frank Ronan in
particular. Attention will also be given to Irish national stereotypes, and their
effect on Ronan’s writing
Children and Disasters: A tribute to Professor Kevin Ronan
Full text link(c) The Author/sIn 1997, Professor Kevin Ronan published a paper in the first ever edition of the Australasian Journal of Disaster and Trauma Studies, titled “The Effects of a “Benign” Disaster: Symptoms of Post-traumatic Stress in Children Following a Series of Volcanic Eruptions”. Over the next 23 years, Kevin and his many colleagues pursued aspects of children and disasters to both improve practice and advance scholarship in this area. In March 2020 we were saddened by the untimely passing of Kevin. As a tribute to Professor Ronan this special issue of the Australasian Journal of Disaster and Trauma Studies brings together accounts of current research and practice initiatives inspired by, building upon, and directly influenced by Professor Ronan’s work
Privilege and Property. Essays on the History of Copyright
Full text linkCopyright law is the site of significant contemporary controversy. In recent years copyright history has transformed as a subject from being one of interest to a few books historians to the focus of sustained historical investigation attracting the attention of scholars from across the humanities. This book comprises a collection of essays on copyright history by leading experts drawn from a range of countries and disciplinary perspectives.
Covering the period from 1450 to 1900, these essays engage with a number of related themes. The first considers the general movement, from the sixteenth century onwards, from privilege to property-based conceptions of copyright protection. The second addresses the relationship between the protection provided for literary and print materials and that provided for other forms of cultural production. The third concerns the significance and relevance of these various histories in shaping and informing contemporary policy and academic practice.
Essays include:
0. The History of Copyright History, by Kretschmer, Deazley & Bently;
1. From Gunpowder to Print: The Common Origins of Copyright and Patent, by Joanna Kostylo;
2. A Mongrel of early modern copyright: Scotland in European Persepctive, by Alastair Mann;
3. The Public Sphere and the Emergence of Copyright: Areopagitica, the Stationers’ Company, and the Statute of Anne, by Mark Rose;
4. Early American Printing Privileges: the Ambivalent Origins of Authors’ Copyright in America, by Oren Bracha;
5. Author and Work in the French Print Privileges System: Some Milestones, by Laurent Pfister;
6. A Venetian Experiment on Perpetual Copyright, by Maurizio Borghi;
7. Les formalités son mortes, vive les formalities! Copyright formalities in nineteenth century Europe, by Stef van Gompel;
8. The Berlin Publisher Friedrich Nicolai and the reprinting sections of the Prussian Statute Book of 1794, by Friedemann Kawohl;
9. Nineteenth Century Controversies relating to the protection of Artistic Property in France, by Frédéric Rideau;
10. Maps, Views and Ornament. Visualising Property in Art and Law: The Case of pre-modern France, by Katie Scott;
11. Breaking the Mould? The Radical Nature of the Fine Art Copyright Bill 1862, by Ronan Deazley;
12. ‘Neither bolt nor chain, iron safe nor private watchman, can prevent the theft of words’: The birth of the performing right in Britain, by Isabella Alexander;
13. The Return of the Commons: Copyright History as a Common Source, by Karl-Nikolaus Peifer;
14. The Significance of Copyright History for the Publishing History and Historians, by John Feather;
15. Metaphors of Intellectual Property, by William St Clair.
The volume is a companion to the digital archive Primary Sources on Copyright (1450-1900), funded by the UK Arts and Humanities Research Council (AHRC): www.copyrighthistory.or
Progress and Distress on the Stratford Estate in Clare during the Eighteen Forties
Full text linkIn the late 1980s and early 1990s, the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters - called the SK correspondence in what follows - became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the SK office in Dublin, they were written mainly by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners - Messrs J. R. Stewart & Son(s) from the mid-1880s onwards -- ceased business in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in book form. The proposed title is Landlords, Tenants, Famine: Business of an Irish Land Agency in the 1840s, a draft of which has now been completed. A majority of the letters in the larger study from which the present article is drawn are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent) ; ‘voluntary’ surrender of land in return for ‘compensation’ upon peacefully quitting; formal ejectment (a matter of last resort on estates managed by SK); landlord-assisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and local agents; major works of improvement (on almost all of the estates managed by SK); applications by SK, on behalf of proprietors, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, ete. Thus, most of the SK correspondence is about aspects of estate management. It seems, in the 1840s, that the only estate in Clare managed by SK was that of the elderly Col. Stratford. Although the files on the relatively small Stratford estate are much less extensive than those on some of the estates investigated in detail in the draft of Landlords, Tenants, Famine, they do refer to most of the core aspects of estate management mentioned above. But in the case of the Clare estate, the material on some of those themes is extremely thin.
A Study on the Fashion Design of Ronan Bouroullec’s Felt-pen Drawing by Applying the Formality : Focusing on cutting tape embroidery
No full text패션은 다양한 분야와의 접목을 통해 표현 영역을 점차 확대하고 있으며, 특히 미술은 중요한 영감의 원천이 되어왔다. 드로잉은 작가의 생각을 구체화하는 발상의 과정인 동시에 직관을 드러내는 창조 행위의 시작으로서, 선으로 그리는 스케치의 의미를 넘어 작가의 개성이 담긴 하나의 작품으로써 평가되기도 한다. 하지만 기존의 패션디자인 연구에서는 드로잉을 접목한 사례가 많지 않다.
이에 본 연구는 로낭 부훌렉 드로잉 작품 중 펠트펜 드로잉에 나타나는 조형성을 응용한 패션디자인에 관하여 연구하였다. 로낭 부훌렉은 유기적인 현대 디자인의 새로운 방향을 모색한 작가로, 그의 드로잉 작업은 독자적인 예술적 가치를 지닌 작품으로 평가받고 있다. 본 연구에서는 이러한 로낭 부훌렉 펠트펜 드로잉의 부드럽고 유기적인 선의 흐름, 반복과 겹침에 의한 시각적 질감을 촉각적 질감으로 표현하기 위해 컷 테이프 자수 기법을 디자인에 접목하였다.
본 연구의 목적은 로낭 부훌렉 펠트펜 드로잉을 컷 테이프 자수 기법을 중심으로 패션디자인에 응용함으로써, 패션의 모티프로서 드로잉의 가치를 재발견하고 패션디자인의 표현영역을 확대하는 데에 있다.
본 연구의 내용 및 방법은 다음과 같다. 이론적 배경에서는 로낭 부훌렉의 작품세계와 펠트펜 드로잉에 관하여 살펴보고, 로낭 부훌렉 펠트펜 드로잉의 조형적 특성을 분석한다. 또한 표현 기법으로써 선택한 테이프 자수 기법의 정의와 종류, 이를 응용한 패션디자인 사례를 분석한다. 분석한 이론적 배경을 토대로 로낭 부훌렉 펠트펜 드로잉의 조형성을 응용한 실물 작품 5벌을 제작한다.
본 연구를 통해 도출된 결론은 다음과 같다.
첫째, 작품의 모티프로서 로낭 부훌렉의 펠트펜 드로잉은 곡선과 직선의 혼합과굵기의 다양한 변화, 반복된 선의 방향성으로 인해 자유롭고 유기적인 선의 흐름을 표현하기에 적합하였다.
둘째, 로낭 부훌렉 드로잉을 테이프 자수 기법으로 표현한 결과, 테이프의 반복과 겹침에 의해 요철감과 결을 형성함으로써 드로잉에 나타난 시각적 질감을 촉각적 질감으로 전환하기에 효과적이었다. 또한 바이어스 컷 테이프의 중첩에 의한 연속면은 밀도 변화에 따라 섬세한 드로잉의 결의 이미지와 볼륨감을 표현하기에 적합하였다.
셋째, 작품의 소재에 있어서 투시성이 있는 반투명의 오간자는 로낭 부훌렉의 펠트펜 드로잉에 나타난 투명감과 중첩의 효과를 부각하기에 적합하였다.
넷째, 로낭 부훌렉의 펠트펜 드로잉에 나타난 주된 색조인 ‘light clear&apos;를 작품에 적용한 결과, 로낭 부훌렉 드로잉에서 나타나는 부드럽고 맑은 이미지를 보다 강조할 수 있었다.
본 연구는 로낭 부훌렉의 펠트펜 드로잉 작품에 나타나는 조형적 특성을 테이프 자수 기법을 통해 패션디자인에 응용하고자 하였다. 이를 통해 패션의 모티프로서 드로잉 작품이 유기적인 선의 흐름을 창출할 수 있음을 확인할 수 있었으며, 컷 테이프 자수 기법이 시각적 질감을 촉각적 질감으로 전환하기에 효과적인 기법임을 확인할 수 있었다. 본 연구를 통해 드로잉을 접목한 다양한 시도가 보다 확대되길 기대한다.
;Fashion has gradually expanded its expressiveness through its interlinking with various fields, and art in particular has been an important source of inspiration. Drawing is the beginning of an act of creativity that embodies the author&apos;s ideas and also reveals his intuition, and is considered to be a work of the writer&apos;s individuality beyond the meaning of a line sketch. However, not many existing fashion design studies have incorporated drawing.
In this study, we studied fashion design that applied the formative properties of felt-pen drawing among Ronan Bouroullec drawing works. Ronan Bouroullec is an author who has sought a new direction in organic modern design, and his drawing work is regarded as a work of independent artistic value. In this study, a cut tape embroidery technique was incorporated into the design to express the smooth and organic flow of lines in these Ronan Bouroullec felt-tongued visual texture by repetition and overlap as tactile
The purpose of this study is to rediscover the value of drawing as a fashion motif and expand the area of expression in fashion design by applying Ronan Bouroullec felt-pen drawing to fashion design with a focus on cut tape embroidery technique.
The content and methods of this study are as follows. In the theoretical background, we examine the work world of Ronan Bouroullec and the felt-pen drawing, and analyze the modeling characteristics of Ronan Bouroullec felt-pen drawing. It also analyzes the definition and type of tape embroidery technique selected as an expression technique, and the fashion design case in which it is applied. Based on the theoretical background analyzed, five real-life works that apply the formative nature of Ronan Bouroullec felt-pen drawing will be produced.
The conclusions drawn from this study are as follows:
First, the felt-pen drawing of Ronan Bouroullec as the motif of the work was suitable to express the flow of free and organic lines due to the mixture of curves and straight lines, various changes in thickness, and the direction of repeated lines.
Second, as a result of expressing Ronan Bouroullec drawing with tape embroidery technique, it was effective to convert the visual texture shown in drawing into tactile texture by forming bumps and cones by repetition and overlap of tape. In particular, continuous surfaces by bias cut tapes were suitable for expressing resolution images and volumetric feelings of fine drawing with varying density.
Third, the translucent Oganza, which were visible in the subject matter of the work, was suitable to highlight the effect of transparency and overlay shown in the felt-pen drawing of Ronan Bouroullec.
Fourth, as a result of applying light clear, the primary shade of color in the felt-pen drawing of Ronan Bouroullec, to the work, the soft and clear image of Ronan Bouroullec was more emphasized.
This study intended to apply the plastic characteristics of Ronan Bouroullec&apos;s felt-pen drawing work to fashion design through tape embroidery techniques. This confirmed that drawing work as a motif of fashion can create an organic stream of lines, and that cutting tape embroidery technique is an effective technique for converting visual texture into tactile texture. It is hoped that the various attempts to graft drawing will be further expanded through this study.Ⅰ. 서론 1
A. 연구의 목적 1
B. 연구 방법과 내용 2
Ⅱ. 이론적 배경 3
A. 로낭 부훌렉의 드로잉에 관한 고찰 3
1. 로낭 부훌렉의 작품세계와 펠트펜 드로잉 3
2. 로낭 부훌렉 펠트펜 드로잉의 조형적 특성 17
B. 테이프 자수에 관한 고찰 26
1. 테이프 자수 기법의 종류 27
2. 컷 테이프 자수 기법을 활용한 패션디자인 사례 32
Ⅲ. 작품 제작 및 해설 37
A. 작품 제작 의도 및 방법 37
B. 작품 및 해설 41
Ⅳ. 결론 83
참고문헌 85
ABSTRACT 8
Protein-protein interactions, sub-cellular localisation and mobility of the human Cdc45 protein.
No full textEukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays a role in the intra-S-phase checkpoint. Its interactions with a variety of replication proteins forming two central complexes, Cdc45/Mcm2-7/GINS (CMG) the putative replicative helicase of eukaryotes, and replisome progression complex (RPC) during the cell cycle and after intra-S-phase checkpoint activation remain to be fully characterized.
The C terminal part of Cdc45 is important for its interaction with Claspin. The interactions of human Cdc45 with the three replication factors Claspin, replication protein A (RPA) and DNA polymerase ¿ are maximal during S phase. Following UVC-mediated DNA damage, Cdc45-Claspin complex formation is reduced whereas the binding of Cdc45 to RPA is not affected. We also show that treatment of cells with UCN-01, Caffeine or Wortmannin does not rescue the UV-mediated destabilisation of Cdc45-Claspin interactions, suggesting that the loss of interaction between Cdc45 and Claspin occurs independently of ATR activation in the intra-S-phase checkpoint.
The sub-cellular localisation of Cdc45 in the cell cycle and following activation of the intra-S-phase checkpoint was also determined. Cdc45 showed a specific nuclear and nucleolar localisation and the Cdc45 association with nucleoli was abolished following UV damage and inhibiting nucleolar transcription. We then determined the regions of Cdc45 needed for its localisation to nuclear compartments. Spcifically, aa101-155 and aa156-169 are required for recruitment of Cdc45 to the nucleus and nucleolus, respectively.
Measuring the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous cells and in cells synchronized at the G1/S transition and during S phase showed that eGFP-Cdc45 mobility is faster in G1/S transition compared to S phase suggesting that Cdc45 is part of larger protein complex formed in S phase. Furthermore, the size of complexes containing Cdc45 was estimated in asynchronous, G1/S and S phase-synchronized cells using gel filtration chromatography; these findings complemented the in vivo FCS data. Analysis of the mobility of eGFP-Cdc45 and the size of complexes containing Cdc45 and eGFP-Cdc45 after UVC-mediated DNA damage revealed no significant changes in diffusion rates and complex sizes using FCS and gel filtration chromatography analyses. These findings suggest that after UV-damage, Cdc45 is still present in a large multi-protein complex and that its mobility within living cells is consistently similar following UVC-mediated DNA damag
Commentary on Warburton's Letter from an Author (1747)
No full textThe first of a number of public commentaries contributing to the mid-eighteenth century debate over the nature of literary property (see also: An Enquiry into the Nature of Literary Property (uk_1762a); An Argument in Defence of Literary Property (uk_1774a)).Warburton, a strong proponent of the common law rights of the author, provided the first significant commentary upon the nature and classification of property and its relevance to, and relationship with, an author's work. Part of this commentary discusses Warburton's attempts to articulate a clear conceptual distinction between the claim of an inventor to the protection of a patent provided by the state, and the natural right of an author to the property in his work
Commentary on Warburton's Letter from an Author (1747)
No full textThe first of a number of public commentaries contributing to the mid-eighteenth century debate over the nature of literary property (see also: An Enquiry into the Nature of Literary Property (uk_1762a); An Argument in Defence of Literary Property (uk_1774a)).Warburton, a strong proponent of the common law rights of the author, provided the first significant commentary upon the nature and classification of property and its relevance to, and relationship with, an author's work. Part of this commentary discusses Warburton's attempts to articulate a clear conceptual distinction between the claim of an inventor to the protection of a patent provided by the state, and the natural right of an author to the property in his work
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