2,959 research outputs found
Colin Humphris
No full text"Colin Humphris 2 Sqdrn. RAAF. 1941 - 1942 Author of - 'Trapped on Timor' (as a result of bombing of Darwin Feb. 19, 1942)".Colin Humphris. 2 Squadron, Royal Australian Air Force 1941 - 1942. Author of - 'Trapped on Timor' (as a result of bombing of Darwin February 19, 1942)
Interview with Colin Wilson, part 4, undated
No full textInterview with Colin Wilson, part 4, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated
Interview with Colin Wilson, part 2, undated
No full textInterview with Colin Wilson, part 2, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated
Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill
No full textIn this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan
Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill
No full textIn this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan
Interview with Colin Jerolmack
No full textColin Jerolmack is an Assistant Professor at New York University
in Sociology and Environmental Studies. He is the author of The
Global Pigeon (forthcoming) and an alumnus of the Robert Wood
Johnson Foundation Scholars in Health Policy Program at Harvard
University
Colin Fraser
No full textPhotograph - Colin Fraser (third from right) in a loaded scow leaving for Fort Chipewyan from Athabasca, Alberta. A group of men are also standing on the pie
From Foucauldian Biopower to Energopower and Infopower:An Interview with Dominic Boyer and Colin Koopman
No full textKirsten Hasberg talks to Dominic Boyer, anthropologist and author of Energopolitics: Wind and Power in the Anthroprocene, and to Colin Koopman, philosopher and author of How We Became our Data: A Genealogy of the Informational Person. Their books published in mid-2019 put forward novel conceptualizations of Foucauldian biopower, which they term infopower and energopower, respectively. Criss-crossing between philosophical conceptualizations and concrete problems like the struggles of renewable energy communities (Boyer) and the influence of economic thinking on datafication (Koopman), the conversations show how Foucauldian concepts are relevant to today's power struggles inherent to the energy transition and the digital transformation.Kirsten Hasberg talks to Dominic Boyer, anthropologist and author of Energopolitics: Wind and Power in the Anthroprocene, and to Colin Koopman, philosopher and author of How We Became our Data: A Genealogy of the Informational Person. Their books published in mid-2019 put forward novel conceptualizations of Foucauldian biopower, which they term infopower and energopower, respectively. Criss-crossing between philosophical conceptualizations and concrete problems like the struggles of renewable energy communities (Boyer) and the influence of economic thinking on datafication (Koopman), the conversations show how Foucauldian concepts are relevant to today's power struggles inherent to the energy transition and the digital transformation
Colin Woodard Reading & Book Signing
No full textJournalist, Colin Woodard, will do a reading and book signing on his new historical novel, The Republic of Pirates which tells the story of the Pirates of the Caribbean. Also author of The Lobster Coast, and Ocean\u27s End. Colin Woodard is native of Maine
Ribozyme catalysis with a twist: active state of the twister ribozyme in solution predicted from molecular simulation
No full textWe present results from molecular dynamics simulations and free energy calculations of the twister ribozyme at different stages along the reaction path to gain insight into its mechanism. The results, together with recent biochemical experiments, provide support for a mechanism involving general-acid catalysis by a conserved adenine residue in the active site. Although adenine has been previously implicated as a general acid acting through the N1 position in other ribozymes such as the hairpin and VS ribozymes, in the twister ribozyme there may be a twist. Biochemical experiments suggest that general acid catalysis may occur through the N3 position, which has never before been implicated in this role; however, currently, there is a lack of a detailed structural model for the active state of the twister ribozyme in solution that is consistent with these and other experiments. Simulations in a crystalline environment reported here are consistent with X-ray crystallographic data, and suggest that crystal packing contacts trap the RNA in an inactive conformation with U-1 in an extruded state that is incompatible with an in-line attack to the scissile phosphate. Simulations in solution, on the other hand, reveal this region to be dynamic and able to adopt a conformation where U-1 is stacked with G33. In this state, the nucleophile is in line with the scissile phosphate, and the N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respectively, as supported by mutational experiments. Free energy calculations further predict the electrostatic environment causes a shift of the microscopic pKa at the N3 position of A1 toward neutrality by approximately 5 pKa units. These results offer a unified interpretation of a broad range of currently available experimental data that points to a novel mode of general acid catalysis through the N3 position of an adenine nucleobase, thus expanding the repertoire of known mechanistic strategies employed by small nucleolytic ribozymes.Peer reviewe
- …
