86,821 research outputs found
Targeted therapy in refractory thyroid cancer: current achievements and limitations
No full textThyroid cancer refractory to conventional treatments lacks effective treatment. Targeted therapy is an emerging therapeutic strategy for these cancers, based on preliminary promising results. Tyrosine kinase inhibitors target both specific oncogenic pathways involved in thyroid cancer progression and aspecific mechanisms such as neoangiogenesis. They are generally well tolerated and most adverse events have low-to-moderate severity. Other classes of drugs have been tested, alone or in combination with tyrosine kinase inhibitors, but so far the results have been limited. The aim of this article is to describe the benefits and limitations of innovative drugs that are currently under investigation in patients with refractory thyroid cancer. © 2011 Future Medicine Ltd
Dimethylallyl diphosphate and geranyl diphosphate pools of plant species characterized by different isoprenoid emissions
No full text
Exploiting Plant Volatile Organic Compounds (VOCs) in Agriculture to Improve Sustainable Defense Strategies and Productivity of Crops
No full textThere is an urgent need for new sustainable solutions to support agriculture in facing current environmental challenges. In particular, intensification of productivity and food security needs require sustainable exploitation of natural resources and metabolites. Here, we bring the attention to the agronomic potential of volatile organic compounds (VOCs) emitted from leaves, as a natural and eco-friendly solution to defend plants from stresses and to enhance crop production. To date, application of VOCs is often limited to fight herbivores. Here we argue that potential applications of VOCs are much wider, as they can also protect from pathogens and environmental stresses. VOCs prime plant’s defense mechanisms for an enhanced resistance/tolerance to the upcoming stress, quench reactive oxygen species (ROS), have potent antimicrobial as well as allelopathic effects, and might be important in regulating plant growth, development, and senescence through interactions with plant hormones. Current limits and drawbacks that may hamper the use of VOCs in open field are analyzed, and solutions for a better exploitation of VOCs in future sustainable agriculture are envisioned
In situ investigation of leaf water status by portable unilateral NMR
No full textA portable unilateral nuclear magnetic resonance (NMR) instrument was used to detect in field conditions the water status of leaves of herbaceous crops (Zea mays, Phaseolus vulgaris), mesophyllous trees (Populus nigra), and natural Mediterranean vegetation characterized by water-spending shrubs (Cistus incanus) and water-saving sclerophyllous trees (Quercus ilex). A good relationship was observed between NMR signal, leaf relative water content, and leaf transpiration in herbaceous leaves undergoing fast dehydration or slowly developing a drought stress. A relationship was also observed between NMR signal and water potential of Populus leaves during the development of a water stress and when leaves recovered from the stress. In the natural vegetation, the relationship between NMR signal and water status was found in Cistus, the species characterized by high transpiration rates, when measured during a drought stress period and after a rainfall. In the case of the sclerophyllous Quercus, the NMRsignal, the relative water content, and the transpiration rate did not change at different leaf water status, possibly because a large amount of water is compartmentalized in cellular structures and macromolecules. The good association between NMR signal and relative water content was lost in leaves exposed for 24 h to dehydration or to an osmotic stress caused by polyethylene glycol feeding. At this time, the transverse relaxation time became longer than in leaves maintained under optimal water conditions, and two indicators of membrane damage, the ion leakage and the emission of products of membrane lipoxygenation [(Z)-3-hexenal, (Z)-3-hexenol, and (E)-2-hexenol], increased. These results taken all together give information on the physiological state of a leaf under a developing stress and show the usefulness of theNMRinstrumentation for screening vegetation health and fitness in natural and cultivated conditions. It is concluded that the portable unilateral NMR instrument may be usefully employed in field conditions to monitor nondestructively the water status of plants and to assist agricultural practices, such as irrigation scheduling, to minimize stomatal closure and the consequent limitation to plant production
Il dispositivo teatrale alla prova del Covid-19. Mediatizzazione, liveness e pubblici
No full textThe COVID-19 emergency had a profound impact on the artistic and cultural sectors, and on performing arts in particular. The lockdown required the suspension of all live performances and rehearsals, including the cancellation of seasons and festivals. Because physical proximity is an essential component of the live shows, this sector will be on pause longer than the others. Since the early stages of the lockdown, the Italian theatre field developed several online initiatives to counterbalance the suspension of its activities. These efforts aimed at keeping the relationship with the remote theatre audiences, by extending the presence of artists, theatres and performances in the online context. However, they also provided an opportunity to reflect at large on the digital transformations of performing arts. The following contribution reflects on how we are researching the online response of the theatrical sector from the perspective of sociology and media studies. The paper aims to contextualise the phenomenon within the processes of theatre mediatisation and digital transformation of liveness, and to the present what we think are the most urgent research questions in this direction. The first part of the article introduces the theoretical premises of the investigation. We present the frame of theatre mediatisation by analysing three interrelated processes: the mediatisation of dramaturgy through the concept of transmedia; the mediatisation of theatrical presence, with the debate on digital liveness, and the mediatisation of the theatrical relationship through social media. The second part will analyse some of the main online initiatives of the theatrical sector, observing how they fit into the previously introduced mediatisation processes. The third part will observe how users have responded to the initiatives presented on social media by some of the main Italian theatres. In the conclusions, we will discuss which research questions we consider crucial to connect the analysis of this critical moment to the main themes of sociological and media studies research on performing arts
Theatre Dispositif and the Challenge of Covid-19: Mediatisation, Liveness and Audiences
No full textThe COVID-19 emergency has had a profound impact on the artistic and cultural sectors, and on performing arts in particular. The lockdown required the suspension of all live performances and rehearsals, including the cancellation of seasons and festivals. Because physical proximity is an essential component of live shows, this sector will be on pause longer than the others. Since the early stages of the lockdown, Italian theatre has developed several online initiatives to counterbalance the suspension of its activities. These efforts have aimed at maintaining contact with the remote theatre audiences, by extending the presence of artists, theatres and performances in the online context. However, they have also provided an opportunity to reflect at large on the digital transformations of performing arts. The following contribution reflects on how we are researching the online response of the theatrical sector from the perspective of sociology and media studies. The paper aims to contextualise the phenomenon within the processes of theatre mediatisation and digital transformation of liveness, and to present what we think are the most urgent research questions in this direction. The first part of the article introduces the theoretical premises of the investigation. We present the frame of theatre mediatisation by analysing three interrelated processes: the mediatisation of dramaturgy through the concept of transmedia; the mediatisation of theatrical presence, with the debate on digital liveness, and the mediatisation of the theatrical relationship through social media. The second part will analyse some of the main online initiatives of the theatre sector, observing how they fit into the previously introduced mediatisation processes. The third part will observe how users have responded to the initiatives presented on social media by some of the main Italian theatres. In the conclusions, we will discuss which research questions we consider crucial to connect the analysis of this critical moment to the main themes of sociological and media studies research on performing arts
Deformation and fluid flow during orogeny at the Paleo-Pacific active margin of Gondwana: the Early Palaeozoic Robertson Bay accretionary complex (North Victoria Land, Antarctica)
No full textStructural investigations, integrated with X-ray diffraction, fluid inclusion microthermometry and oxygen-stable isotope analyses are used to reconstruct the deformation history and the palaeo-fluid circulation during formation of the low-grade, turbidite-dominated Early Palaeozoic Robertson Bay accretionary complex of north Victoria Land (Antarctica). Evidence for progressive deformation is elucidated by analysing the textural fabric of chronologically distinct, thrust-related quartz vein generations, incrementally developed during progressive shortening and thickening of the Robertson Bay accretionary complex. Our data attest that orogenic deformation was mainly controlled by
dissolution–precipitation creep, modulated by stress- and strain-rate-dependent fluid pressure cycling, associated with local and regional permeability variations induced by the distribution and evolution of the fracture network during regional thrusting. Fracture-related fluid pathways constituted efficient conduits for episodic fluid flow. The dominant migrating fluid was pre-to-syn-folding and associated with the migration of warm (160–200 °C) nitrogen- and carbonic (CO2 and CH4)-bearing fluids. Both
fluid advection and diffusive mass transfer are recognized as operative mechanisms for fluid–rock interaction and vein formation during continuous shortening. In particular, fluid–rock interaction was the consequence of dissolution–precipitation creep assisted by tectonically driven cooling fluids moving through the rock section as a result of seismic pumping. The most likely source of the migrating fluids would be the frontal part of the growing accretionary complex, where fluids from the deep levels in the hinterland are driven trough channelization operated by the thrust-related fracture (fault) systems
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