1,488 research outputs found
Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis
No full textObjectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED) visits data in Edmonton, Canada for the period from 1992 (April) to 2002 (March). We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR) and their 95% confidence intervals (95% CI). Results: The results are reported for the interquartile range (IQR = 17.9 ppb) for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2); for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3); for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3). Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Supplemental Material, Pt_Exp_Case_Mgm_Care_Supplemental_Data_-_Quotes_REVISED - Patients’ Experiences of Nurse Case-Managed Osteoporosis Care: A Qualitative Study
No full textSupplemental Material, Pt_Exp_Case_Mgm_Care_Supplemental_Data_-_Quotes_REVISED for Patients’ Experiences of Nurse Case-Managed Osteoporosis Care: A Qualitative Study by Lisa A. Wozniak, Brian H. Rowe, Meghan Ingstrup, Jeffrey A. Johnson, Finlay A. McAlister, Debbie Bellerose, Lauren A. Beaupre, and Sumit R. Majumdar in Journal of Patient Experience</p
sj-pdf-1-caj-10.1177_08465371231214699 – Supplemental material for Canadian Association of Radiologists Thoracic Imaging Referral Guideline
No full textSupplemental material, sj-pdf-1-caj-10.1177_08465371231214699 for Canadian Association of Radiologists Thoracic Imaging Referral Guideline by Candyce Hamel, Barb Avard, Catherine Belanger, Patrick Bourgouin, Stephen Lam, Daria Manos, Alan Michaud, Brian H. Rowe, Kevin Sanders and Ana-Maria Bilawich in Canadian Association of Radiologists Journal</p
Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene
No full textComplement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene. The L allele confers protection against severe malaria in Papua New Guinea, probably because erythrocytes with low CR1 expression, are less able to form pathogenic rosettes with Plasmodium falciparum-infected erythrocytes. Despite the biological importance of erythrocyte CR1, the genetic mutation controlling CR1 expression level remains unknown. We investigated the possibility that mutations in the upstream or 3' untranslated regions of the CR1 gene could control erythrocyte CR1 level. We identified several novel polymorphisms; however, the mutations did not segregate with erythrocyte CR1 expression level or the H and L alleles. Therefore, high and low erythrocyte CR1 levels cannot be explained by polymorphisms in transcriptional control elements in the upstream or 3' untranslated regions of the CR1 gene
JAH_Appendix_T3_Tracking_Tool_Cummings_JAH-18-344 – Supplemental material for Fractured Care: A Window Into Emergency Transitions in Care for LTC Residents With Complex Health Needs
No full textSupplemental material, JAH_Appendix_T3_Tracking_Tool_Cummings_JAH-18-344 for Fractured Care: A Window Into Emergency Transitions in Care for LTC Residents With Complex Health Needs by Greta G. Cummings, Patrick McLane, R. Colin Reid, Kaitlyn Tate, Sarah L. Cooper, Brian H. Rowe, Carole A. Estabrooks, Garnet E. Cummings, Stephanie L. Abel, Jacques S. Lee, Carole A. Robinson and Adrian Wagg in Journal of Aging and Health</p
Aviation Innovator to Receive Honorary Degree at University of Dayton Commencement
No full textNews release announces that the University of Dayton will present an honorary doctorate of engineering degree to Brian H. Rowe
An inner city emergency medicine rotation does not improve attitudes toward the homeless among junior medical learners
No full textIntroduction
Learners in the emergency department (ED) frequently encounter individuals who are homeless. We sought to evaluate the effect of an inner city emergency medicine rotation at the Royal Alexandra Hospital (RAH) on the attitudes of medical students and residents towards this population.
Methods
Data were collected both pre- and post-rotation using an electronic survey. Data collected included demographic information and as well as scores on the Health Professionals’ Attitudes Towards the Homeless Inventory (HPATHI). Pre- and post-survey results were compared using Wilcoxon tests.
Results
Ninety-eight students completed the rotation. A total of 40 (41%) students completed both pre- and post-surveys. Demographic information was available for 66 respondents. Most participants were male (42 {64%}), single (47 {71%}), and 30 years of age or younger (59 {89%}). Most participants were of a Caucasian or East/South Asian background (61 {92%}) and grew up in an urban setting (51 {77%}). Overall, 43 (90%) participants saw at least one person who was homeless during their rotation. There was no significant difference between pre- and post-aggregate scores (z = -0.78, p = 0.44), or any of its three subscales (Personal Advocacy, Social Advocacy, and Cynicism).
Conclusion
First year residents and medical students are frequently exposed to patients who are homeless during an inner city ED rotation. Attitudes towards these patients did not significantly change following the rotation. Educational objectives should be set to improve attitudes of learners towards those with unstable housing throughout the ED rotation.Kingsway Emergency AgencyCanadian Institutes of Health Research (CIHR
Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies
No full textRosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions. Previous work showed that rosetting does not enhance parasite invasion under standard in vitro conditions. We hypothesised that rosetting might promote invasion in the presence of host invasion-inhibitory antibodies, by allowing merozoites direct entry into the erythrocytes in the rosette and so minimising exposure to plasma antibodies. We therefore investigated whether rosetting influences invasion in the presence of invasion-inhibitory antibodies to MSP-1. We found no difference in invasion rates between isogenic rosetting and non-rosetting lines from two parasite strains, R29 and TM284, in the presence of MSP-1 antibodies (P = 0.62 and P = 0.63, Student's t test, TM284 and R29, respectively). These results do not support the hypothesis that rosettes protect merozoites from inhibitory antibodies during invasion. The biological function of rosetting remains unknown
Behaviour of buried pipelines subjected to external loading.
No full textThe research presented in this Thesis was carried out at the University of Sheffield under
the supervision of Dr I. C. Pyrah and Dr W. F. Anderson, and Mr G. Leach at British Gas
Engineering Research Station (ERS). The research was financially supported by a British
Gas Research Scholarship and by the Overseas Research Students Awards Scheme.
The Author would like to express his sincere gratitude to his supervisors for their invaluable
help, guidance and encouragement during the development of the research.
The Author is also grateful to Dr S. R. Mi for his interest and assistance throughout the
research. Special thanks also go to Dr S. J. Wheeler for his supervision during the first year
of the research and sound advice in the initial stage of the work.
The Author would like to express his gratitude to all members of the geotechnics group at
the University of Sheffield for the useful discussions and comments. Special thanks and
appreciation are extended to the staff at the ERS, particularly Mr E. Middleton for
providing the data of the field tests and constructive comments.
The laboratory tests were performed at ERS Soils Laboratory for which the Author is
thankful to the laboratory staff. The Author must also thank British Gas for providing the
computer hardware and software for performing the numerical analyses, and the printing
facilities to produce the Thesis. Thanks also go to Mr D. Reay and Mr B. Bellwood at the
Gas Research Centre of British Gas for ensuring continuous financial support throughout
the award period.
Finally, the Author wishes to thank his family and friends for their endless support and
encouragement throughout the period of study in the UK. Without them, this Thesis may
never have been completed
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