211 research outputs found
Robison, Millard Joseph
No full textMillard Robison was born on April 16, 1897 in McAdam Junction, New Brunswick to parents George and Margaret Robison. He spent his childhood in New Brunswick with his sisters, Isabelle, Alma and Jessie and brothers, Herman and Norman. The Robison family later moved to Lethbridge, Alberta. Millard attended high school at Central School and was very active on the debate team, competing against other high schools in southern Alberta. As a young man, he was employed as a hardware clerk. Both Millard and his brother, Norman would serve and ultimately lose their lives in the Great War.
On July 31, 1916, Millard Robison enlisted with the 78th Depot Battery Canadian Field Artillery. Gunner Robison arrived in England on March 15, 1917, and remained in England until embarking for France on May 24, 1917. Upon arrival in France, Gunner Robison was taken on strength by the 8th Brigade Canadian Field Artillery. He would serve in France and Belgium for a total of six months.
On November 19, 1917, Gunner Robison received gunshot wounds to his head and side during the battle at Passchendaele. He would pass away later that day and was laid to rest at Dozinghem Military Cemetery. Millard Robison was awarded the British War Medal and Victory Medal. His mother, Margaret received the Memorial Cross and death plaque in honour of her son
Robison, Norman James
No full textNorman Robison was born on August 17, 1893 in McAdam Junction, New Brunswick to parents George and Margaret Robison. He spent his childhood in New Brunswick with his sisters, Isabelle, Alma and Jessie and brothers, Herman and Millard. The Robison family later moved to Lethbridge, Alberta. As a young man, Norman was employed as a fireman with the CPR. Both Norman and his brother, Millard would serve and ultimately lose their lives in the Great War.
On September 23, 1914, Norman Robison enlisted with the 10th Battalion CEF. He was among the first Canadian men to volunteer for overseas service. Pte Robison arrived in France on February 15, 1915. He would serve on the frontlines with the Fighting Tenth until June 6, 1916 when a shrapnel wound to his knee would force him to return to England. Following his convalescence, he was granted his request to return to his unit in September 1917. Pte Robison would spend another year at the frontlines with the 10th Battalion, seeing action at Passchendaele, Amiens, the Scarpe and the Hindenburg Line. In August 1918, he received a promotion to Lance Corporal. Lance Corporal Robison wrote letters home to his family, which vividly described his experiences on the frontline.
On September 29, 1918, Lance Corporal Robison died of wounds he had received while serving in France. He was laid to rest at Queant Communal Cemetery British Extension. Norman Robison was awarded the 1914/15 Star, British War Medal and Victory Medal. His mother, Margaret received the Memorial Cross and death plaque in honour of her son
Oregon survey of clinic immunization practice changes due to the COVID-19 pandemic
No full textSteve Robison, Stefanie Murray, & Mimi Luther, Oregon Health Authority, Immunization Program.Title from PDF caption (viewed on January 4, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Tell Me: 30 Stories
No full textBy Mary Robison Counterpoint Press (Paperback, $14.00, ISBN: 1582432589, 10/2002) Thirty brief, sharply delineated short stories written over three decades by Robison (Days) chronicle emotional dislocation with witty dispassion. Robison’s characters, usually members of middle-class families, are often pictured grappling with the redefinition of roles, such as the teenaged star-gazing narrator of “An Amateur’s Guide to the Night” and her pill-popping single mother who pass for sisters and go on double-dates together. Or the newly idle Helen of “Independence Day,” recently returned to her father’s grand lakeside house in Ohio, who halfheartedly resists the pressure of her estranged husband, Terry, to get on with her life. Epiphanies are of less interest to Robison than rendering the shimmering immediacy of situation: “I could be getting married soon. The fellow is no Adonis,” establishes straightaway the art teacher of “In Jewel,” whose engagement means a way out of the dead-end eponymous miner town she’s always lived in. Robison locates her fairly comfortable characters anywhere from Beverly Hills (“Smoke”) to Ophelia, Ohio (“While Home”), to Washington, D.C. (“Smart”); they are waiting for rides in the rain or for babies to be born or for life, simply, to go on. And in every story her characters make valiant, hit-or-miss attempts to connect with one another. The brevity of these tales sometimes leaves the reader hanging, especially since their author delights in oblique details and non sequiturs. Yet nothing is superfluous, and in the spare sadness of Robison’s prose entire lives are presented. As the fiancée of “In Jewel” concludes, “All that I’ve ever owned or had is right out here for you to examine.” Copyright 2002 Reed Business Information, Inc. (from Publishers Weekly)https://egrove.olemiss.edu/mwp_books/1319/thumbnail.jp
What Ashland parents told us about religious exemptions
No full textprepared by: Steve Robison, Amanda Timmons, Lorraine Duncan, Jim Gaudino, Martha Priedeman, Hank Collins.Title from PDF cover (viewed on January 15, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
A complementary understanding of residential energy demand, consumption and services
No full textThis chapter explores potential ways to implement, and benefits for policymaking of, the complementary use of two different types of modelling for analysing residential energy consumption and ethnographic research. The more traditional approach of techno-economic modelling is considered alongside agent-based modelling that incorporates both causal and intentional relationships; ethnographic approaches provide 'thick understanding' of the relationships between social and technical elements and the environment. In doing so, the chapter builds on real examples from academic-policy engagement in the EU on energy demand, consumption and services. We examine three myths of the role of modelling in policymaking and propose practical ways of employing different types of modelling in a complementary way to increase policymakers' understanding of residential energy demand, consumption and services. Finally, we make three concrete recommendations for developing future interdisciplinary work on integrating social and technical models for informing policy.Energy and Industr
Simulating Gender Stratification
No full textThe simulation of promotional competitions in corporations described herein allows comparisons of suggested reasons for the paucity of women in the highest level of corporate management. Runs with small, medium and large-sized companies all give similar results. The strongest effect is evidenced when men are given a bonus in performance evaluations. Similar stratification is observed when men's scores are drawn from a distribution with increased variance. Other explanations (increased female attrition, career delays for women, line-staff divisions, and external labor market) do not, by themselves produce strong gender stratification, but could add to that produced by biased evaluations.Glass Ceiling, Gender Stratification, Promotion, Performance Evaluation Bias, Computer Simulation
Multiplexed immunoassay development for precision medicine diagnostics and protein characterization using silicon photonic microring resonators
No full textPrecision medicine offers the potential to transform healthcare by utilizing detailed biochemical insights into a patient’s disease state for therapeutic decision-making. Numerous disease specific biomarkers have emerged, but few are as dynamic and information-rich as those associated with the immune system. The immune system operates through a pathogen specific, biologically conserved response to coordinate detection and clearance. Immune cell associated signaling molecules, cytokines, modulate the immune response and their associated dynamics are ideal for monitoring host response. Profiling the immune response correlated to system perturbations provides a clinically valuable result for functional diagnostics.
Immunoassays are a powerful tool to quantitatively measure cytokine levels in biological solutions. While enzyme-linked immunosorbent assays have been the gold standard technique, multiplexed approaches have rapidly developed in response to the need for more complex biological signatures to precisely describe disease states. While many of these assays demonstrate robust intra-assay performance, variable inter-assay and multi-center performance is a consistent issue. Additionally, the inherent physiological fluctuations from patient-specific, but disease independent sources have largely hindered the clinical implementation of these assays.
This dissertation describes promising approaches to address the analytical and clinical challenges facing immune profiling guided precision medicine. Chapter 2 outlines the fundamental requirements for developing robust multiplexed immunoassays with silicon photonic microring resonator arrays. Using this basic protocol for assay development, Chapters 3 and 4 describe two distinct approaches toward diagnosing and monitoring infectious disease related states. Chapter 3 focuses on designing a functional diagnostic immunoassay for latent tuberculosis infection (LTBI) with the absolute assay output normalized by each subject’s basal immune response. Using this personalized normalization strategy, machine learning feature selection yielded promising results toward a diagnostic signature. Chapter 4 describes a multiplexed immune profiling approach incorporating rich temporal dynamics throughout the treatment of sepsis. The rapid immunoassay provides the cytokine trajectories of each subject throughout treatment, illustrating the dynamic changes accompanying immune challenge and subsequent therapeutic intervention. Chapter 5 leverages the near-real time monitoring capabilities of the platform to characterize the differential binding kinetics of monomeric and dimeric therapeutic antibodies as a means of structural characterization. Finally, Chapter 6 discusses the future of the LTBI diagnostic signature development, outlining a significant expansion of the biomarker panel, informatic analysis, and subject study enrollment.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01The student, Heather Robison, accepted the attached license on 2017-11-29 at 10:02.The student, Heather Robison, submitted this Dissertation for approval on 2017-11-29 at 10:19.This Dissertation was approved for publication on 2017-11-29 at 15:09.DSpace SAF Submission Ingestion Package generated from Vireo submission #11777 on 2018-03-13 at 10:34:09Made available in DSpace on 2018-03-13T17:35:24Z (GMT). No. of bitstreams: 3
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Previous issue date: 2017-11-29Embargo set by: Seth Robbins for item 105462
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Mechanisms of Cohesin Function Revealed by Analysis of Smc3
No full textA central problem in biology is how genetic material is organized and inherited during cell divisions without loss of information. The conserved protein complex cohesin functions to ensure chromosomes are partitioned equally when cells divide. Cohesin mediates sister chromatid cohesion, chromosome condensation, efficient repair of DNA damage and regulation of transcription. The activity by which cohesin performs these functions is through DNA tethering. Tethering can occur between two sister chromatids or within a single chromatid to bring together two separate positions along its length. Within this dissertation, I will describe novel insights into the mechanism by which cohesin performs these critical activities on chromosomes. I chose to study this problem in the budding yeast Saccharomyces cerevisiae because of the unparalleled genetic tools available in this model eukaryote.Cohesin consists of four core subunits referred to in yeast as Mcd1p, Scc3p, Smc1p, and Smc3p, whereas spatiotemporal control of cohesin activity depends on auxiliary factors. To better understand cohesin architecture and regulation, I performed a genetic screen to identify novel mutants of the Smc3p subunit. Characterization of these mutants has revealed functions for previously undescribed regions of Smc3p and new activities for previously described domains that further our understanding of this complex molecular machine. First, I describe a series of mutations at the interface between Smc3p and Mcd1p termed the DNA “exit gate”. This investigation revealed an unexpected role for this interface in loading cohesin on chromosomes. Second, I reveal a novel role for the Smc3p hinge domain in cohesion maintenance that is independent of its ability to stably bind chromosomes. This discovery lends additional weight against a simple “embrace” model for DNA tethering by cohesin still supported by many in this field. Moreover, this observation suggests that communication between the Smc3p hinge, Mcd1p, and regulator Pds5p is required for cohesion maintenance. Finally, I show that a specific region in the middle of the cohesin ring is critical for a step in the process of cohesin loading onto chromosomes. This result is surprising since it suggests that a contortion of the cohesin ring is critical for it to productively bind chromosomes. In sum, this dissertation advances our understanding of the mechanism by which cohesin functions and supports a variation of the “handcuff” model in which an activity after DNA binding is required for cohesin to achieve tethering
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