4 research outputs found
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Building Peace after War. By Mats Berdal. New York: Routledge, 2009. 186p. 127.00 cloth. - The Political Economy of Transitions to Peace: A Comparative Perspective. By Galia Press-Barnathan. Pittsburgh: University of Pittsburgh Press, 2009. 272p. 27.95 paper.
No full textThe Relationship between Cultural Dimensions and Perceptions of Victimization by Teachers
No full textA repository of information for the NICE CROWD project, during the 2023 - 2024 term, led by PIs Kimberly E. Kamper-DeMarco, Jill M. Norvilitis, Jennifer Mitsuyama-Brandenberger, and NICE Chair Brianna Fitapelli
The Relationship between Cultural Dimensions and Perceptions of Victimization by Teachers
No full textA repository of information for the NICE CROWD project, during the 2023 - 2024 term, led by PIs Kimberly E. Kamper-DeMarco, Jill M. Norvilitis, Jennifer Mitsuyama-Brandenberger, and NICE Chair Brianna Fitapelli
