84 research outputs found
Molecular lymphatic mapping of sentinel lymph nodes
No full textThe present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Molecular Lymphatic Mapping, uses traditional dye/radioactive tracer based techniques in conjunction with a nucleic acid marker to identify and label the SLN, not only for current diagnostic methods, but for archival purposes. In addition, MLM can be used to deliver a therapeutic gene or genes to the SLN to activate tumor immunity to tumor cells, and/or to inhibit tumor metastases. The methods may be combined with therapeutic intervention including chemotherapy and radiotherapy
Microsatellite Alterations as Diagnostic and Prognostic Molecular Markers in Patients With Cancer
No full textDNA markers for management of cancer
No full textA method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor region may be identified in the bone marrow, serum, plasma, and tumor tissue samples of cancer patients. Methods of melanoma, neuroblastoma, colorectal cancer, breast cancer and prostate cancer detection, staging, and prognosis are also provided
Enhanced Axillary Evaluation Using Reflector-Guided Sentinel Lymph Node Biopsy: A Prospective Feasibility Study and Comparison With Conventional Lymphatic Mapping Techniques
No full textTree-based language complexity of Thompson\u27s group F
No full textThe definition of graph automatic groups by Kharlampovich, Khoussainov and Miasnikov and its extension to C-graph automatic by Elder and the first author raise the question of whether Thompson\u27s group F is graph automatic. We define a language of normal forms based on the combinatorial caret types , which arise when elements of F are considered as pairs of finite rooted binary trees. The language is accepted by a finite state machine with two counters, and forms the basis of a 3-counter graph automatic structure for the group
Method and apparatus for in vivo collection of circulating biological components
No full textThe invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe
Comparative Analysis of Mesenteric and Peripheral Blood Circulating Tumor DNA in Colorectal Cancer Patients
No full text- …
