171,818 research outputs found
Rodolfo R. Brenner
No full textNo es tarea fácil resumir en unas pocas palabras la personalidad y trayectoria científica del Dr. Rodolfo Roberto Brenner. ¿Quién no conoce al Dr. Brenner en el ámbito universitario y científico de este país? Baste decir que gracias a los aportes que ha realizado a la ciencia, especialmente en el campo de la bioquímica de lípidos, la Argentina y la Universidad de La Plata, donde realizó casi toda su trayectoria, son conocidas hoy en el mundo.Instituto de Investigaciones Bioquímicas de La Plat
Rodolfo R. Brenner
No full textNo es tarea fácil resumir en unas pocas palabras la personalidad y trayectoria científica del Dr. Rodolfo Roberto Brenner. ¿Quién no conoce al Dr. Brenner en el ámbito universitario y científico de este país? Baste decir que gracias a los aportes que ha realizado a la ciencia, especialmente en el campo de la bioquímica de lípidos, la Argentina y la Universidad de La Plata, donde realizó casi toda su trayectoria, son conocidas hoy en el mundo.Instituto de Investigaciones Bioquímicas de La Plat
The symmetric signature
No full textWe define two related invariants for a d-dimensional local ring (R,,k) called syzygy and differential symmetric signature by looking at the maximal free splitting of reflexive symmetric powers of two modules: the top-dimensional syzygy module SyzdR(k) of the residue field and the module of Kähler differentials ΩR/k of R over k. We compute these invariants for two-dimensional ADE singularities obtaining 1/|G|, where |G| is the order of the acting group, and for cones over elliptic curves obtaining 0 for the differential symmetric signature. These values coincide with the F-signature of such rings in positive characteristic
Barrier, Brenner Pass, 1945
No full textView of a check-point at the Brenner Pass, photographed by Dr. Edgar Hyde of the 91st Evacuation Hospital, possibly during a trip to Innsbruck, Austria, in August 1945.Title by Edgar Hyde from the original negative enclosure
Brenner Pass, 1945
No full textView from the Brenner Pass, photographed by Dr. Edgar Hyde of the 91st Evacuation Hospital, possibly during a trip to Innsbruck, Austria, in August 1945.Title by Edgar Hyde from the original negative enclosure
The pathogenesis of atypical proliferative Brenner tumor : an immunohistochemical and molecular genetic analysis
No full textBrenner tumors are ovarian tumors, usually benign, containing epithelium that resembles transitional epithelium. As with other epithelial tumors there exist frankly malignant tumors and tumors that display greater proliferation than the benign Brenner tumors but lack destructive infiltrative growth, and these have been designated 'atypical proliferative' (borderline) Brenner tumors. There have been no well-documented cases of atypical proliferative Brenner tumors that have exhibited malignant behavior. Based on shared morphologic features it is generally believed that atypical proliferative Brenner tumors develop from benign Brenner tumors. The aim of the present study was to confirm this impression by investigating the immunohistochemical and molecular genetic features of benign and atypical proliferative Brenner tumors. Immunohistochemical staining for p16, fluorescence in-situ hybridization (FISH) for CDKN2A (p16-encoding gene) and mutational analysis of the genes commonly mutated in ovarian tumors were performed. p16 immunostaining was positive in the epithelial component of 12 (92%) of 13 benign Brenner tumors, but completely negative in all 7 atypical proliferative Brenner tumors. FISH identified homozygous deletion of CDKN2A in the epithelial component of all atypical proliferative Brenner tumors, but CDKN2A was retained in all benign Brenner tumors. Two PIK3CA somatic mutations were detected in the stromal component in 1 (5%) of 20 Brenner tumors and 3 somatic mutations (1 in KRAS and 2 in PIK3CA) were identified in the atypical epithelial component of 2 (29%) of 7 atypical proliferative Brenner tumors. In summary, our findings suggest that loss of CDKN2A and, to a lesser extent, KRAS and PIK3CA somatic mutations have a role in the progression of a benign to an atypical proliferative Brenner tumor
Anatomic study on the transverse cervical vessels perforators in the lateral triangle of the neck and harvest of a new flap: the free supraclavicular transverse cervical artery perforator flap.
No full textAnatomic study on the transverse cervical vessels perforators in the lateral triangle of the neck and harvest of a new flap: the free supraclavicular transverse cervical artery perforator flap.
Cordova A, D'Arpa S, Pirrello R, Brenner E, Jeschke J, Moschella F.
Source
Cattedra di Chirurgia Plastica e Ricostruttiva, Dipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy. [email protected]
Abstract
BACKGROUND:
Vessels in the supraclavicular area and their contribution to skin vascularization have always been studied for flaps planning in head and neck reconstruction and many pedicled flaps have been described based on those vessels. Little has been written instead about the vascularization of the supraclavicular skin itself for the use as a free flap. The purpose of this anatomical study was to assess the vascularization of the supraclavicular skin and the possibility of finding an adequate pedicle to harvest it as a free flap in order to close the donor site directly.
METHODS:
A total of 25 cadavers, 10 formalin fixed and 15 fresh, have been studied in cooperation with the Division for Clinical-Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria and the Laboratoire d'Anatomie, Universiteé R. Descartes, Paris, France.
RESULTS:
The supraclavicular skin was nourished by perforators coming from the transverse cervical artery and constantly present in an average number of four. Venous drainage was accomplished through the superficial cervical vein, and not through the venae comitantes of the transverse cervical artery.
CONCLUSIONS:
Based on the results of this investigation, a free supraclavicular transverse cervical artery perforator (STCAP) flap seems to be feasible pedicled on perforators from the transverse cervical artery and drained by the superficial cervical vein. Due to its thickness and skin texture, it can be indicated for facial and intraoral defects, with the limitations of a relatively short pedicle. Primary closure of the donor site can be accomplished concealing the scar in the neck creas
p63 expression in ovarian tumours: A marker for Brenner tumours but not transitional cell carcinomas
No full textAims: To investigate p63 expression in ovarian neoplasms. Methods and results: Immunohistochemistry using an antibody that detects all p63 isoforms was performed on 103 primary ovarian neoplasms of different histological types. Diffuse nuclear immunoreactivity of p63 was demonstrated in the 17 benign and five borderline Brenner tumours. Only one of the six malignant Brenner tumours displayed p63 expression. p63 immunoreactivity was absent in all the ovarian transitional cell carcinomas (TCC), but was demonstrated extensively in TCCs of the urinary bladder. Besides focal p63 expression in epidermal basal cells of immature and mature teratomas, all other ovarian lesions were devoid of p63 expression. p63 expression was also demonstrated in cervical transitional cell metaplasia and Walthard cell nests of fallopian tubes. Conclusions: Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours. The loss of expression in malignant Benner tumours suggests a role for p63 in Brenner carcinogenesis. The distinct patterns of p63 expression in TCCs in the ovary and urinary bladder may help in their differential diagnosis. © 2007 The Authors.link_to_subscribed_fulltex
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Vascular anatomy of the supraclavicular area revisited: feasibility of the free supraclavicular perforator flap.
No full textVascular anatomy of the supraclavicular area revisited: feasibility of the free supraclavicular perforator flap.
Cordova A, Pirrello R, D'Arpa S, Jeschke J, Brenner E, Moschella F.
Source
Cattedra di Chirurgia Plastica e Ricostruttiva, Dipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, Palermo, Italy. [email protected]
Abstract
BACKGROUND:
The supraclavicular skin has been studied extensively and used as a pedicled flap for face and neck reconstruction. Its use as a free flap has not paralleled its use as a pedicled flap. The authors performed an anatomical investigation to assess the possibility of harvesting a free supraclavicular flap with the donor-site scar lying in the supraclavicular crease. In this article, the authors present the results of their anatomical study together with the preliminary clinical applications.
METHODS:
Skin vascularization and feasibility of a free supraclavicular perforator flap were studied on 25 cadavers (15 fresh cadavers injected with colored latex at the Universiteé René Descartes in Paris; and 10 formalin-fixed, noninjected cadavers at the Innsbruck Medical University). The flap was used in two patients at the Plastic Surgery Department of the University of Palermo for a cutaneous facial reconstruction and intraoral reconstruction after cancer excision.
RESULTS:
An average of four perforators were consistently found in the supraclavicular area coming from the transverse cervical artery. Venous perforators drain into the superficial venous plexus rather than into the venae comitantes of the transverse cervical artery. Two flaps were successfully used based on these vessels.
CONCLUSIONS:
The vascularization of the supraclavicular skin depends on skin perforators coming from the transverse cervical artery and draining into the superficial venous plexus. Based on these vessels, a reliable free supraclavicular flap seems to be safe to harvest, with the scar hidden in the supraclavicular crease. The preliminary clinical applications of such a flap gave promising results, suggesting its potential applications
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