1,658 research outputs found
Annette Harvey Diary, 1906-1910
No full textAnnette Harvey, of Arkansas, West Virginia, and Ohio, recounts events of her daily life in this 'Line a Day' diary. She was the daughter of William Hope Harvey, aka 'Coin' Harvey, a well-known businessman, politician, author and founder of the resort of Monte Ne and the Ozark Association. Annette's brief entries record visits, housework, dances, parties, a train trip to New York, weather, church services and socials over a 5 year period, 1906-1910. Addresses and miscellaneous thoughts, quotations, poems, are recorded at the end of the volume. A photograph of her home made in 1906 is tipped in at the front of the diary
Interview with Annette Lareau
No full textAnnette Lareau is the Stanley I. Sheerr Professor in the Department of Sociology at the University of Pennsylvania. She is the author of Unequal Childhoods: Class, Race, and Family Life (University of California Press). Unequal Childhoods won the best book award from three sections of the American Sociological Association: Sociology of the Family, Sociology of Children and Youth, and Sociology of Culture (co-winner)
Therapeutic Targeting the Cell Division Cycle 25 (CDC25) Phosphatases in Human Acute Myeloid Leukemia — The Possibility to Target Several Kinases through Inhibition of the Various CDC25 Isoforms
No full textThe cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent kinases (CDKs). CDC25s seem to have a role in the development of several human malignancies, including acute myeloid leukemia (AML); and CDC25 inhibition is therefore considered as a possible anticancer strategy. Firstly, upregulation of CDC25A can enhance cell proliferation and the expression seems to be controlled through PI3K-Akt-mTOR signaling, a pathway possibly mediating chemoresistance in human AML. Loss of CDC25A is also important for the cell cycle arrest caused by differentiation induction of malignant hematopoietic cells. Secondly, high CDC25B expression is associated with resistance against the antiproliferative effect of PI3K-Akt-mTOR inhibitors in primary human AML cells, and inhibition of this isoform seems to reduce AML cell line proliferation through effects on NFκB and p300. Finally, CDC25C seems important for the phenotype of AML cells at least for a subset of patients. Many of the identified CDC25 inhibitors show cross-reactivity among the three CDC25 isoforms. Thus, by using such cross-reactive inhibitors it may become possible to inhibit several molecular events in the regulation of cell cycle progression and even cytoplasmic signaling, including activation of several CDKs, through the use of a single drug. Such combined strategies will probably be an advantage in human cancer treatment
CDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors
No full textCell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. CDC25 inhibition is regarded as a possible therapeutic strategy for the treatment of human malignancies, including acute myeloid leukemia (AML). We investigated the in vitro effects of CDC25 inhibitors on primary human AML cells derived from 79 unselected patients in suspension cultures. Both the previously well-characterized CDC25 inhibitor NSC95397, as well as five other inhibitors (BN82002 and the novel small molecular compounds ALX1, ALX2, ALX3, and ALX4), only exhibited antiproliferative effects for a subset of patients when tested alone. These antiproliferative effects showed associations with differences in genetic abnormalities and/or AML cell differentiation. However, the responders to CDC25 inhibition could be identified by analysis of global gene expression profiles. The differentially expressed genes were associated with the cytoskeleton, microtubules, and cell signaling. The constitutive release of 28 soluble mediators showed a wide variation among patients and this variation was maintained in the presence of CDC25 inhibition. Finally, NSC95397 had no or only minimal effects on AML cell viability. In conclusion, CDC25 inhibition has antiproliferative effects on primary human AML cells for a subset of patients, and these patients can be identified by gene expression profiling
Mitteilungen aus dem Brenner-Archiv / Stirne an Stirne : Zu zwei Briefen Christine Lavants an Hermann Lienhard
No full textInterview with Annette J. Smith
No full textInterview in seven sessions, December 2010 to January 2011 with Annette J. Smith, visiting professor of French at Caltech from 1970 to 1982, appointed associate professor with tenure in 1982, promoted to professor of French in 1985, and Professor of Literature emeritus since 1993.
Family history, childhood and education in Algiers, Algeria. Family history and background of late husband, Caltech Professor of Literature David R. Smith (1960-1990). Bachelor’s degree in Classics (1948) from Sorbonne in Paris. Attended the School of Professors of French Abroad at the Sorbonne and taught at the University of Wales in Swansea. Master’s degree in English. Marriage to D. Smith and move to the United States.
Teaches at Scripps College and Claremont Men’s College [now Claremont McKenna College], where she had tenure position. Caltech hires D. Smith as professor and A. Smith as lecturer in French language. D. Smith as Joseph Conrad scholar. Doctorate degree (1964) and dissertation on author Nicole Védrès. D. Smith made Master of Student Houses (1969-1975); life in Virginia Steele Scott house. Descriptions of faculty and atmosphere within Division of Humanities and Social Sciences (HSS), beginning when Hallett Smith was chair. Friendship with Max and Manny Delbrück. Cultural life at Caltech; D. Smith brings poets, actors, directors and musicians to campus. Life as professor’s spouse and efforts to improve working conditions and salaries for female staff. Sexual discrimination in HSS and support for Jenijoy La Belle. History and founding of Baxter Art Gallery (1970), significant exhibitions organized by D. Smith, closing of Baxter Art Gallery (1985). Important relationships with Caltech professors, postdocs and staff: R. Sperry, R. Feynman, A. Hibbs, J. and F. Audouze, D. and C. Cesarsky, J.-P. Bibring, and N. and C. Corngold.
Elevated to associate professor (1982). Literature courses she taught and impressions of students. Two books accepted for publication: one on Arthur de Gobineau and translation of poems by Aimé Césaire. Explanation of racial theories of Gobineau and discussion of his fiction; impact of Gobineau’s racist writings and theories, including appropriation by Nazis. Discussion of Darwinism. Comments about translating poetry and working with poet Clayton Eshleman on four books of Césaire’s poetry. Description of Césaire’s life and politics and his importance as a leader and author. Reads her translations of Césaire’s poems.
Impressions of foreign language study at Caltech and further descriptions of HSS, including some unfortunate hires and tension in the division. D. Smith’s illness and death. Teaching in Papeete, Tahiti, 1990-1991. Circular nature of her life and work. Purchase of land and building of second home in Point Dume, Malibu, (1980-1981) and celebratory party there. Expressions of gratitude for Caltech and its brilliant scientists and community
The censor without, the censor within: the resistance of Johnstone’s improv to the social and political pressures of 1950s Britain
No full textKeith Johnstone's improv, popularly known through the Theatresports format, was forged in the cultural and historical context of 1950s Britain. In this paper I will argue that Johnstone's incarnation of theatrical improvisation was defined by its reaction to the normalising forces exerted by the social elite upon the broader population and by civilised society upon the individual.
Johnstone's improv was a reaction against the Lord Chamberlain’s power to censor the British stage and a challenge to the internalised 'censor' British society of the time implanted in the minds of his students, stunting their creative imaginations. Johnstone borrowed elements of professional wrestling to break down the regimented conventions of the theatre space and enliven the spectator-performer relationship. As well as echoing Roland Barthes’ idealistic analysis of professional wrestling (Barthes, 1984: n.p.), Johnstone’s improv shares Barthes’ critique of the authority of the author and allows meaning to be generated out of the encounter between performers and spectators in the instant of the performance’s emergence. Through these processes, Johnstone’s improv defies the censor without (The Lord Chamberlain) by rooting out the censor within (the socially learnt inhibitions to the creative imagination).
By delineating the political and social pressures at play in the historical context of 1950s Britain and the ways that the stylistic conventions of Johnstone's improv resist and subvert these forces, I will demonstrate the emancipatory power latent in this mode of popular performance. This is a particularly timely analysis given the increasing authority of free market economics to dictate what appears on contemporary British stages, and the internalised censor that panoptical CCTV and social media is implanting within the minds of British citizens today
Mitteilungen aus dem Brenner-Archiv / Stirne an Stirne : Zu zwei Briefen Christine Lavants an Hermann Lienhard
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