1,721,031 research outputs found
The role of human eye in resource-limited settings: preserving essential diagnostic skills in dermatology
No full textUse of a large patient database to analyze disease burden and treatment patterns among patients with vitiligo
No full textImatinib, dasatinib and nilotinib: a review of adverse cutaneous reactions with emphasis on our clinical experience.
No full textIn the last years, several tyrosine kinase inhibitors (TKIs) have been developed and approved for human cancer treatment. Imatinib mesylate was the first of this novel family of drugs that target cancer-specific molecules and signalling pathways. The appearance of imatinib resistances led to the introduction of second-generation TKIs with higher potency and selectivity, such as dasatinib and nilotinib. However, the range of activity of these agents is not simply directed at tumour cells. Patients and their clinicians are indeed frequently confronted with the cutaneous side-effects associated with the employ of these drugs, which represent the most common non-hematological adverse reactions. For this reason, a systematic dermatological survey of patients receiving these therapies is highly important, and an early and appropriate dermatological treatment is required. In this review, we analyse the clinical and pathological characteristics of the most commonly reported adverse skin events associated with first- and second-generation tyrosine kinase inhibitors, with a particular emphasis on our clinical experience
Cuteneous blisters as the presenting signs of recurrent thyroglossal duct cyst in a child.
No full textAtypical exanthem with acral involvement in adult patients associated with human herpesvirus 7 active replication: A case series
No full textAn "atypical exanthem" (AE) is an eruptive skin eruption that differs in morphology and etiology from classical exanthems and is often a reason for urgent medical evaluation. The most frequent cause of AEs is a viral infection, but an accurate etiology cannot be established basing on the sole clinical features. Human herpesviruses (HHV) have been often suspected as etiologic agents or cofactors in atypical rashes. We performed a retrospective analysis of adult patients presenting an atypical exanthem associated with HHV-7 active replication in our center. The charts of patients were reviewed and the demographic, clinical and laboratory data collected. Nine patients (six males and three females) were included in the study, with a mean age of 43 years for men and of 26 years for women. All patients presented active HHV-7 replication in plasma during the rash, which turned negative after the exanthem resolved. The exanthem displayed a maculopapular pattern involving the trunk, limbs and, notably, the acral regions, in six patients. In three cases the exanthem was confined to only the acral sites. In most cases, there was no fever and the inflammatory indices remained unchanged. Antihistamines, topical and systemic corticosteroids were used as treatment, with excellent symptom control. We propose adding skin manifestation associated with HHV-7 to the concept of atypical exanthems, in particular those localized to the acral regions
Acute adverse reaction to self-prescribed potassium hydroxide 5% solution in a child with papular acrodermatitis of childhood
No full textAn atypical presentation of tuberculous gumma heralding a diagnosis of lymph node tuberculosis: Hindsight is 20/20
No full textBleomycin-induced flagellate dermatitis: report of four paediatric cases.
No full textThe reduced concentration of bleomycin hydrolase enzyme in the skin, pruri- tus and the concomitant radiotherapy could have had a synergistic role in the accumulation of the drug and triggered the flagellate dermatitis
Successful ustekinumab treatment of severe refractory psoriasis vulgaris in a hemodialysis patient
No full textIs There a Role for the Detection of Autoantibodies in the Clinical Practice of Treating Infants with Bullous Pemphigoid? A Case Report.
No full textWe present a case of infantile bullous pemphigoid (BP) triggered by primary infection with varicella zoster virus and we analyze the correlation between autoantibody levels and disease activity. With this report we suggest that serum autoantibody titers may not necessarily mirror the clinical course of the disease or represent a helpful tool in guiding therapeutic decisions in infantile BP
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