1,005 research outputs found

    Modeling and simulation of dissolution and erosion of porous solids

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    Tablet dissolution modeling has seen multiple eff orts from both empirical and physical approaches. We present an expandable 3-D Cartesian framework for modeling many of the physical processes involved in tablet dissolution, which allows for powerful model manipulation. The primary focus of this framework is the way in which the moving boundaries are handled, while the internal mechanisms represent one possible set of physical process interaction. The effects of external fluid shear and internal density profiles are compared for several cases including active and inactive internal processes.M.S.Includes bibliographical referencesIncludes vitaby Daniel Braid

    Characterization and modeling the dissolution performance of tablets focusing on powder processing effects

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    Tablet dissolution modeling has seen many efforts from both empirical and physical approaches. We present an expandable 3-D Cartesian framework for modeling multiple physical processes involved in tablet dissolution, which allows for a more straightforward generation of models while maintaining powerful model manipulation. Also presented is an experimental technique for quantifying solvent penetration and dynamic surface erosion. Two types of solid oral dosage forms are experimentally characterized and then modeled. One system is governed by drug particle dissolution, the other by surface erosion.Ph. D.Includes bibliographical referencesIncludes vitaby Daniel Braid

    Overwintering behavior of the entomopathogenic nematodes Steinernema scarabaei and AND Heterohabditis bacteriophora (Rhabditida: Steinernematidae and Heterorhabditidae) and their white grub hosts (Coleoptera: Scarabaeidae)

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    Entomopathogenic nematodes (EPN) Steinernema scarabaei and Heterorhabditis bacteriophora, species endemic to New Jersey turfgrass habitats, have great potential as biological control agents of various white grub pest species. EPN have potential for long-term white grub suppression, but to more reliably achieve this, a better understanding is necessary of the nematodes' survival mechanisms expresses during harsh seasonal conditions. Infective juveniles (IJ) may employ similar vertical migratory patterns as other soil-inhabiting animals during harsh seasonal conditions. To determine the existence of vertical relocation as an overwintering mechanism we investigated the vertical distribution of S. scarabaei and H. bacteriophora relative to (1) fluctuating soil temperature and (2) changing vertical position of two white grub hosts, Japanese Beetle (Popillia japonica) and oriental beetle (Anomala orientalis), during the late fall, winter and early spring season. The vertical distributions of white grub and IJ populations were monitored every 14-18 days in established turf plots (3-4 years old) from mid-October to the first week of May in two consecutive years (2006-2007 and 2007- 2008). The vertical distribution of S. scarabaei, H. bacteriophora, and Steinernema carpocapsae did not change from the fall to the spring season. Soil temperature did not appear to influence IJ vertical distribution. The vertical distribution of both white grub species changed with temperature during fall and spring but not in winter. Overwintering S. scarabaei and H. bacteriophora IJs were only recovered in the soil. There was no evidence for successful in-host survival or latent infection in endemic white grub populations. Although the relationship between temperature and vertical distribution for EPN and their white grub hosts differed, a considerable degree of spatial and temporal overlap was observed between respective EPN and host populations. Overwintering EPN appear to survive primarily or exclusively as IJs in the soil and presumably employ various physiological and biochemical mechanisms as survival strategies during seasonally cold and freezing conditions.M.S.Includes bibliographical references (p. 34-40)by Daniel Ethan Elmowit

    Advice to all parties: By the author of The true-born English-man.

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    16p. ; 4⁰.The author of The true-born English-man = Daniel Defoe.Reproduction of original from the Harvard University Houghton Library.Moore, 99English Short Title Catalog, ESTCN2029.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    An essay at a plain exposition of that difficult phrase a good peace. By the author of the Review:

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    52p. ; 8⁰.The author of the Review = Daniel Defoe.Reproduction of original from the British Library.Moore, 221Goldsmiths', 4810English Short Title Catalog, ESTCT56892.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    Some thoughts upon the subject of commerce with France: By the author of the Review.

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    48p. ; 8⁰.Author of the Review = Daniel Defoe.An argument in favor of reopening trade with France.Reproduction of original from the University of London's Goldsmiths' Library.Moore, 257Hanson, 1854Goldsmiths', 5018English Short Title Catalog, ESTCN23850.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    The Spanish descent. A poem. By the author of The true-born Englishman:

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    16p. ; 8⁰.Author of The true-born Englishman = Daniel Defoe."Probably a piracy" (Foxon).Reproduction of original from the Harvard University Houghton Library.Foxon, D152English Short Title Catalog, ESTCN23890.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    A collection of the writings of the author of The true-born English-man.:

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    [2],112,117-289,[1]p. ; 8⁰.The author of The true-born English-man = Daniel Defoe.The unauthorized edition.Publisher identified in Moore.Text and register continuous despite pagination.Reproduction of original from the British Library.Moore, 54English Short Title Catalog, ESTCT71926.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    An enquiry into occasional conformity: Shewing that the dissenters are no way concern'd in it. By the author of the preface to Mr. Howe.

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    31,[1]p. ; 4⁰.The author of the preface to Mr. Howe = Daniel Defoe.Reproduction of original from the British Library.Moore, 48English Short Title Catalog, ESTCT32986.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)

    Advice to all parties: By the author of The true-born English-man.

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    [4],24p. ; 4⁰.The author of The true-born English-man = Daniel Defoe.In this edition the ornament on the title-page is in seven lines; and there is a price below the imprint: 'Price 6d.'.Reproduction of original from the British Library.Moore, 99English Short Title Catalog, ESTCT66298.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)
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