1,721,075 research outputs found
Assessment of plasma homocysteine levels in shift healthcare workers
No full textPrevious studies have indicated an association between shift work and cardiovascular disease. Increased plasma homocysteine levels has been proposed as a cardiovascular risk factor independent of other conventional risk factors.
Our aim is to verify the usefulness of plasma homocysteine as a screening test to prevent cardiovascular diseases in shift workers.
Thirty rotating shift nurses and 28 daytime nurses have been submitted during 18 months to regular taking of arterial pressure and body weight. Venous blood was drawn to measure glycaemia, triglycerides, plasma cortisol level, HDL cholesterol, blood cell count, alanine-aminotransferase, aspartate-aminotransferasi, gamma-GT, and plasma homocysteine.
No increase in average plasma homocysteine in rotating shift nurses, nor a higher frequency in hyperomocisteinemia than in daytime workers was found. A significant difference was observed in body weight and systolic blood pressure (p<0.05), which resulted higher in rotating shift workers than in daytime workers. A significant increase was observed in alanine-aminotransferase (ALT) among shift workers (p<0.05).
Plasma homocysteine measurement should not be employed as a screening test for the prevention of cardiovascular disease in rotating shift workers
Shift work and cardiometabolic risk
No full textShift work is frequently associated with coronary heart disease. Medical research indicate metabolic disturbance among shift workers, which is characterized by associated modifications in the concentration of serum glucose and serum lipids, hypertension and obesity, especially addominal weight. Atrasversal study has been carried out: 193 (126 females and 67 males) healthcare shift workers were compared with 221 (160 females and 61 males) day workers. Medical history, health examination including anthropometric and arterial blood pressure measurements were assessed. All participants were submitted a standardized questionnaire on health-related behaviours and biochemical determinations (fasting plasma glucose, HDL-cholesterol, triglycerides). Job seniority of shift work resulted at 13.5 +/- 8.2 among shift workers and 19.0 +/- 11.3 among day workers. Assessment of the metabolic syndrome relevance was defined according to the criterions proposed by the International Diabetes Federation. The 20% shift workers (33% males and 13% females) was affected by metabolic syndrome against 12% non shift workers (20% males and 9% females). The most frequently altered parameter, apart from metabolic syndrome, was high abdominal obesity, which occurred in 64% of the sample (70% shift workers vs 58% day workers). The results of multiple logistic regression attested the presence of a higher relative risk among shift workers regarding both the prevalence of a metabolic syndrome (OR 2,1 - 95% Cl 1.15-3.86) and the excess in abdominal obesity (OR 1.8 - 95% Cl 1.16-3.25). After adjusting confusing factors such as smoke, age, alchool, consumption, physical activity, scholastic degree, a OR 2.9 - 95%Cl 1,53-5.53 and a OR 1.9 - 95%.Cl 1.32-3.86 were confirmed
In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-gamma, IL-6): role of the nitric oxide-L-arginine pathway.
No full textValutazione di parametri immunitari in soggetti professionalmente esposti a campi elettromagnetici: risultati preliminari
No full textLaboRisCh: an algorithm for assessment of health risks due to chemicals in research laboratories and similar workplaces
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Rapporto sulla frequenza degli infortuni e delle malattie professionali nel settore smaltimento dei rifiuti
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