2,938 research outputs found
Rozpor ako východisko, láska ako smer u Simone Weilovej (Contradiction as base, Love as direction in writings of Simone Weil)
No full textArticle is explaining contradiction and love, Simone Weil‘s essential terms of hermeneutics of human Being. It introduces close relation of these terms with her understanding of God as well as with her overall concept of religion. Author also mentions Simone Weil‘s inspirations with philosophical and spiritual concepts of the East
Ship detection using GNSS-reflectometry in backscattering configuration
No full textThe chance of exploiting the Global Navigation Satellite Systems-Reflectometry (GNSS-R) remote sensing technology in the field of maritime surveillance and ship traffic monitoring has been explored in the very recent past. The conventional bistatic GNSS-R is based on the acquisition of GNSS navigation messages in a forward-scattering geometry, where the investigated region surrounds the specular reflection point. The peculiarities of the ship detection problem, where man-made dihedral structures come into play, make the conventional configuration unsuitable for such an application, especially from spaceborne platforms. Very recently, the backscattering configuration has been demonstrated to greatly enhance the presence of targets within GNSS-R delay-Doppler maps (DDM). In this paper, a thorough comparison of the forward-and back-scattering configurations for ship detection application from spaceborne GNSS-R instruments is presented in order to quantitatively evaluate the benefits of the backscattering configuration with respect to the conventional one. The analysis is performed by computing the signal-to-noise-plus-clutter ratio in both configurations as a function of the sea state, ship orientation and radar look angle
Ship detection using GNSS-Reflectometry in backscattering configuration
No full textThe chance of exploiting the Global Navigation Satellite Systems-Reflectometry (GNSS-R) remote sensing technology in the field of maritime surveillance and ship traffic monitoring has been explored in the very recent past. The conventional bistatic GNSS-R is based on the acquisition of GNSS navigation messages in a forward-scattering geometry, where the investigated region surrounds the specular reflection point. The peculiarities of the ship detection problem, where man-made dihedral structures come into play, make the conventional configuration unsuitable for such an application, especially from spaceborne platforms. Very recently, the backscattering configuration has been demonstrated to greatly enhance the presence of targets within GNSS-R delay-Doppler maps (DDM). In this paper, a thorough comparison of the forward- and back-scattering configurations for ship detection application from spaceborne GNSS-R instruments is presented in order to quantitatively evaluate the benefits of the backscattering configuration with respect to the conventional one. The analysis is performed by computing the signal-to-noise-plus-clutter ratio in both configurations as a function of the sea state, ship orientation and radar look angle
“I beg you to tell me what has become of Djamila”: The Political Mobilization of Simone de Beauvoir’s Readers During the Boupacha Affair
No full textBy Sophia Millman This is a condensed version of a Masters thesis dedicated to the political mobilization of Simone de Beauvoir’s readers. The citations from the letters were translated from French by the author. *** On June 2, 1960, the French government ordered all copies of the daily Algiers edition of Le Monde seized and destroyed to suppress the publication of Simone de Beauvoir’s article “Pour Djamila Boupacha.” Beauvoir, a self-professed “woman of letters”, not “of action[1]”, and one ..
Anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of vestibular migraine: A prospective observational cohort study
No full textBackground: Vestibular migraine is considered the most common cause of recurrent vertigo for which specific treatments are missing. Monoclonal antibodies against calcitonin gene-related peptide,, are effective in preventing migraine. Since CGRP is also detected in human cochlear and vestibular organs it may also play a role in vestibular physiology. Methods: This is a prospective observational cohort study, aiming at evaluating the efficacy of erenumab, fremanezumab or galcanezumab for the treatment of fifty vestibular migraine patients. We assessed mean monthly days with headache and dizziness/vestibular symptoms, pain intensity and migraine-related clinical burden occurring for 18 months. Results: Response to treatment was excellent as 45 (90%) patients had at least a 50% reduction in vertigo frequency, 43 (86%) had at least a 50% reduction in headache frequency, and 40 (80%) a MIDAS reduction of at least 50%. Overall, 39 (78%) patients had a concomitant reduction of all three parameters. Mean monthly days with dizziness/vestibular symptoms showed an overall significant decrease from a mean of 10.3 ± 1.9 at baseline to 0.8 ± 0.3 days, difference 9.5 (CI 95% 3.6, 15.4; p < 0.001) after twelve months. Conclusion: We show that anti-CGRP mAbs may be effective in the treatment of Vestibular Migraine. Their use should be encouraged early in the disease course to allow for a better symptom control and quality of life improvement
Are anti-calcitonin gene-related peptide monoclonal antibodies effective in treating migraine aura? A pilot prospective observational cohort study
No full textBackground: About 15% to one third of migraineurs experience aura symptoms. Aura is a reversible focal neurological phenomenon involving visual, sensory, speech, and motor symptoms that usually precede migraine pain. Monoclonal antibodies against calcitonin-related peptide (anti- CGRP mAbs) are effective in preventing chronic and episodic migraine, but little is known about their effectiveness on specifically preventing migraine with aura. Methods: This is a pilot prospective observational cohort study, aiming at evaluating the effectiveness and safety of Erenumab, Fremanezumab or Galcanezumab for the treatment of migraine aura. We enrolled 14 patients at the Headache Centre of University Federico II of Naples. Duration of follow-up was 12 months. We assessed mean monthly days with aura symptoms, with or without subsequent headache, as well as mean monthly days with headache and mean monthly MIDAS score, by reviewing standardized paper patient headache diaries every three months. Results: A significant decrease in mean monthly aura days was observed throughout the observation period (median baseline: 13, interquartile range: 4-16; after 12 months: 1, interquartile range: 0-3, p < 0.001). We observed a statistically significant decrease in mean monthly headache days as well (median baseline 21, interquartile range: 16-30; after 12 months: 5, interquartile range: 4-7, p < 0.001). During the 12-month treatment period, none of the 14 patients reported mild or serious adverse events. Conclusion: Our findings suggest that anti-CGRP mAbs are highly effective in migraine with aura, both in reducing mean monthly aura days and mean monthly days with headache
The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack
No full textBesides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance
A comparative study of form and theology in the works of Flannery O'Connor and Simone Weil
No full textIn this comparative study of the form and theology of Flannery O'Connor and Simone Weil I interrogate how Weil's philosophical writings and her theology illuminate O'Connor's use of both narrative and non-fictional forms, and her Catholicism. The Introduction analyses how Weil's concept of superposed reading provides a new method of approaching both O'Connor, her writings, and O'Connor
studies, and focuses on how such apparently different women interconnect. Chapter One explores how both Weil and O'Connor attempt to write their theologies on the
souls of their readers yet are each subject to constraints imposed by form. Weil's concept of locating equilibrium between incommensurates is discussed, and her
distinctively philosophical approach to fictions and fictionality is used to investigate O'Connor's notion of prophetic fictions and the writer's role. Chapter Two assesses how both writers revivify Christian paradoxes. Weil's monstrous concept of affiiction, and O'Connor's use of the grotesque genre to jolt secular man into an
awareness of the sacred are scrutinised. Chapter Three studies how both writers consider an encounter between God and man is possible through the action of grace. My Conclusion interrogates how Weil's work can deepen our understanding of O'Connor's writings, and examines how successful O'Connor is at realising a truly
Christian literature. I conclude that despite being a writer of powerful fictions, O'Connor can not be totally successful in her mission as writer-prophet because
ultimately fiction escapes orthodoxy
Microlinices benthovus Simone 2014
No full textbenthovus, Microlinices Simone, 2014 Microlinices benthovus Simone, 2014: 575–578 (figs 6A–J, 7A–H, 11A–C). Gastropoda, Naticidae Paratypes (22 spc): MZSP 105269. Paratypes 1 (15 spc): MZSP 105270. Paratypes 2 (16 spc): MZSP 105271. Paratypes 3 (7 spc): MZSP 105272. Localities: Brazil, Espírito Santo, off Itaúnas, Abrolhos Slope, 18°59' S, 37°50' W, MD55 sta. DC 73, 637 m depth, 27 May 1987; 1) 19°00' S, 37°48' W, MD55 sta. DC72, 950– 1050 m, 27 May 1987; 2) off Regência, 19°40' S, 37°48' W, MD55 sta. CB77, 790– 940 m depth, 27 May 1987; 3) off Itaúnas, Abrolhos Slope, 19°01' S, 37°47' W, MD55 sta. CB79, 1500–1575 m depth, 28 May 1987. Collectors: P. Bouchet, J.H. Leal and B. Métivier. Preservation: Dry. Remarks: Former MNHN, Paris. The catalogue number MZSP 105250 is mentioned twice in Simone’s (2014) paper, among the paratypes of M. ibitingus Simone, 2014 and M. benthovus. This duplicity was a mistake by the author: the latter is an erroneous designation and should be disregarded. The only valid paratype lots for M. benthovus are the ones shown above.Published as part of Cavallari, Daniel C., Dornellas, Ana Paula S. & Simone, Luiz Ricardo L., 2016, Second annotated list of type specimens of molluscs deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil, pp. 1-59 in European Journal of Taxonomy 213 on page 10, DOI: 10.5852/ejt.2016.213, http://zenodo.org/record/384012
A head‐to‐head observational cohort study on the efficacy and safety of monoclonal antibodies against calcitonin gene–related peptide for chronic and episodic migraine
No full textObjective: To compare the effectiveness and safety of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine, through real-world data. Background: Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been tested extensively in several clinical trials for both episodic and chronic migraine, showing high effectiveness, safety, and tolerability; however, there are no prospective real-world studies intending to compare their efficacy and safety. Methods: This is a prospective observational cohort study comparing the effectiveness and safety profiles of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine. We enrolled 140 patients at the Headache Centre of University Federico II of Naples, with a history of multiple failed treatments with validated migraine preventatives. Framenezumab, erenumab, or galcanezumab were administered for 12 months. The mean monthly days with headache, Migraine Disability Assessment (MIDAS) score, and adverse events were evaluated during the run-in period and every 3 months by reviewing standardized paper patient headache diaries. Results: We found a mean reduction of migraine monthly days from baseline of -12.0 (-9.8, -14.1) in the galcanezumab group, -12.3 (-10.2, -14.3) in the fremanezumab group, and -10.8 (-8.5, -13.1) in the erenumab group (for all, p < 0.001). We found a mean reduction of MIDAS score of -32.6 (-26.6, -38.5) in the galcanezumab group, -33.4 (-28.0, -38.9) in the fremanezumab group, and -29.2 (-23.0, -35.4) in the erenumab group (for all, p < 0.001). We found no significant differences between mAbs in the reduction of mean monthly days with headache and MIDAS score. We found a more rapid effect of galcanezumab and erenumab compared to fremanezumab in medication overuse headache patients after 3 months of treatment (-10.8 and -11.1 vs. -4.0 days; p = 0.029). Conclusion: Our results confirm the therapeutic benefits of anti-CGRP mAbs. There is no evidence that suggests that one antibody may be superior to the others in terms of effectiveness, both in chronic and episodic patients
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