1,721,098 research outputs found
Pilomatrixoma: A case report
No full textPilomatrixoma (Malherbe's calcifying epithelioma) is a benign tumor that arises from the matrix of hair follicles. It has the propensity to occur in the head region and often involves the eyelid or eyebrow. Although pilomatrixoma is well known to dermatologists and ophthalmologists, it is not widely recognized among otolaryngologists as a cause of a solitary, round, firm, intradermal nodule in head skin in a child. We report the findings in a 5-year-old child who developed a single pilomatrixoma of the right upper eyebrow
Massive mediastinal enlargement due to extramedullary haematopoiesis in a patient with MYH9-related thrombocytopenia
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Marginal zone-related neoplasms of splenic and nodal origin
No full textBackground. The marginal zone is an anatomically distinct B-cell compartment of lymphoid tissue with an abundant antigenic influx. Among marginal zone-derived lymphomas the WHO classification listed, in addition to extranodal marginal zone B-cell lymphoma of MALT type, two other marginal zone B-cell neoplasms: splenic marginal zone B-cell lymphoma (+/- villous lymphocytes) and nodal marginal zone B-cell lymphoma (+/- monocytoid B cells). These two entities are well characterized histologically, but specific biological markers are lacking. Treatment options are heterogeneous, including a watch-and-wait policy, surgery with or without chemotherapy, purine analogs, and interferon. No prospective studies have been conducted so far.
Information sources. Clinical and pathologic data were reviewed by searches of the published medical literature, including searches in PubMed(R), important printed publications, and abstracts presented at recent hematology and pathology meetings.
State of the art. Splenic and nodal marginal zone lymphomas are typical low-grade lymphomas with an indolent course. A subset of patients, however, presents with more aggressive disease and have a shorter survival. Clinical and biological prognostic factors identified in reported series are heterogeneous. The role played by hepatitis C virus (HCV) in marginal zone lymphomas is not fully elucidated, but there is demonstration that eradication of HCV infection in splenic lymphoma with villous lymphocytes causes regression of the lymphoma. The optimal treatment has not yet been identified. Retrospective series, however, show that splenectomy is a good option if symptoms from the presence of spleen enlargement or cytopenias need to be treated. The utility of purine analogs and of anti-CD20 immunotherapy needs to be clarified in prospective trials.
Perspectives. Clinicians and pathologists should cooperate to define stringent diagnostic criteria for these indolent disorders. The optimal therapeutic approach and the role of new treatments need to be assessed in prospective clinical trials
Nodal marginal zone lymphoma: current knowledge and future directions of an heterogeneous disease
No full textWandering Spleen: An Unusual Cause of Recurrent Abdominal Pain
No full textWandering spleen is a rare condition characterized by
abnormal migration of the spleen from its normal fixed
location in the left upper abdomen. During these movements, the spleen may twist around the splenic vascular
pedicle, leading to recurrent episodes of hypoperfusion,
abdominal pain, and ultimately infarction and necrosis.
Imaging studies are pivotal to help reach a diagnosis and
surgical intervention is the only definitive treatment
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