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PROPHYLAXIS AND TREATMENT OF NEONATAL ISOIMMUNE THROMBOCYTOPENIA - DESCRIPTION OF 2 CASES
No full textPrognostic value of abnormal EEG transients in preterm and full-term neonates
No full textThe prognostic value of abnormal EEG transients was investigated in 362 subjects submitted to EEG recording during the neonatal age and followed-up at least until the 12th month of corrected age. The incidence of negative and positive spikes and sharp waves, of rhythmic sharp theta and delta activities and of alpha discharges were evaluated by means of a quantitative score. These abnormal EEG transients appeared to be generally rare and even absent in a large number of subjects. In infants with normal outcome their incidence tends to increase from low postmenstrual ages towards term period. Full-term newborns with abnormal neurological outcome presented a significantly higher incidence of these transients. Preterm infants with unfavourable evolution showed a higher incidence only when submitted to EEG recording at around term age. However, no difference between subjects with normal and abnormal outcome was detected in preterm infants when evaluated at low postmenstrual ages. The hypothesis that at low postmenstrual ages brain damage might, on the one hand, give rise to abnormal transients and, on the other, alter the 'capability' of manifesting them (together with other EEG maturational aspects), might explain these results
Final height in girls with slowly progressive untreated central precocious puberty.
No full textA group of six girls with slowly progressive idiopathic precocious puberty (IPP) and a good initial height prognosis was followed without treatment. At first observation the girls had a bone age advance over chronological age of no more than 18 months, a Delta height age (Delta HA):Delta bone age (Delta BA) ratio higher than 0.9 and height prognosis was unimpaired after 6 months. During the first two years of follow-up the girls maintained an acceptable height potential. The Delta HA:Delta BA ratio remained constant at greater than 0.9. Predicted height showed a slight increase or decrease (+/- 4 cm). The girls were reevaluated after the age of 14 years and followed-up until they reached their final height (FH). The mean FH (155.4 +/- 2.8 cm) was below the mean target height (159.3 +/- 4.2 cm) by 3.9 cm (range -2.1 to -6.7 cm); this difference was not statistically significant. The FH was more than 5 cm below the target height in only one case; this girl had the most precocious onset of puberty, at 6 years of age. In three cases FH was between the 3rd and 10th centiles. These three girls had a target height below 158 cm (< 25th centile). Girls with slowly progressive IPP and a good initial height prognosis preserved height potential with an acceptable final height without therapy
Immunoreactive parathyroid hormone and calcitonin in children's cerebrospinal fluid.
No full textCerebrospinal fluid (CSF) levels of immunoreactive parathyroid hormone (iPTH) and immunoreactive calcitonin (iCT) were measured by radioimmunoassay in 23 outpatient leukemic children on maintenance chemotherapy. These hormones were detectable in the CSF of all patients: iPTH 148 +/- 11 pg/ml (mean +/- SEM); iCT 14.3 +/- 0.8 pg/ml. iPTH and iCT were also measured in serum (iPTH 396 +/- 18 pg/ml; iCT 32.3 +/- 1.4 pg/ml). CSF values were significantly lower (p less than 0.001) than serum concentrations; no significant correlation between the two compartments was found. Our study indicates the presence of iPTH and iCT in the CSF of children
Low serum thymic hormone levels in patients with in insulin dependent diabetes mellitus (IDDM)
No full textA case of Noonan syndrome with unusual clinical severity and familial factor XII deficiency
No full textWe report the case of a term infant with cystic hygroma revealed by fetal ultrasound scanning and characteristic craniofacial dysmorphism at birth, compatible with a clinical picture of Noonan syndrome. The infant had a significant factor XII deficiency, found also in his parents. In the following months, a worsening of cardiorespiratory function, due to a rapidly progressive hypertrophic cardiomyopathy, occurred, causing the death of the infant
La associazione di IL-7 e FLT-3 ligand incrementa la crescita dei progenitori mieloidi umani di sangue cordonale supportata da stroma
No full text
Constantly discontinuous EEG patterns in full-term neonates with hypoxic-ischaemic encephalopathy
No full textObjectives: Selected EEG features were evaluated in 21 constantly discontinuous tracings recorded on the same number of full-term neonates with hypoxic-ischaemic encephalopathy. Methods: The tracings were examined without using interval amplitude as the basis for distinguishing between burst-suppression and non-burst-suppression patterns. Results: The results were related to outcomes and other clinical parameters (severity of hypoxic-ischaemic encephalopathy, pO(2) levels and drug intake). Conclusions: Features defining the grade of EEG discontinuity (i.e. maximum interval duration, minimum burst duration and interval amplitude) significantly related to outcome and, in most cases, to the grade of hypoxic-ischaemic encephalopathy. Other features (amplitude of slow waves within the burst and incidence of abnormal EEG transients) related to pO(2) levels. The consumption of anticonvulsant drugs increased EEG discontinuity, but this effect did not seem dose-related. Finally, the persistence of a constantly discontinuous EEG pattern after the first week of life is a sign of unfavourable prognosis. In full-term neonates with hypoxic-ischaemic encephalopathy quantitative analysis of all constantly discontinuous EEGs seems more useful than only describing burst-suppression patterns on the basis of interval amplitude. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved
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