101,204 research outputs found
Préparation de sérums anti-Pasteurella multocida monospécifiques de type
No full textPerreau Pierre, Botto T. Préparation de sérums anti-Pasteurella multocida monospécifiques de type. In: Bulletin de l'Académie Vétérinaire de France tome 123 n°6, 1970. pp. 283-291
Pengembangan Formulasi Sediaan Gel Ekstrak Botto'-Botto' (Chromolaena odorata (L) King& H.E. Robins) Sebagai Obat Luka
No full textLuka adalah suatu penyakit akibat hilang/rusaknya sebagian dari jaringan tubuh. Keadaaan ini dapat disebabkan oleh beberapa faktor seperti trauma benda tajam ataupun benda tumpul, ledakan, zat kimia, perubahan suhu, sengatan listrik, atau gigitan hewan. Daun tanaman Chromolaena odorata (L.) King & H.E. Robins mengandung senyawa saponin, alkaloid, tanin, steroid, antrakuinon.
Telah dilakukan penelitian tentang pengembangan formulasi sediaan gel ekstrak daun Botto’-Botto’ (Chromolaena odorata (L.) King & H.E.Robins) sebagai obat luka. Penelitian ini bertujuan untuk memperoleh suatu formula sediaan gel ekstrak daun Chromolaena odorata (L.) King & H.E. Robins dengan karakteristik farmaseutik dan stabilitas fisik yang baik
serta konsentrasi ekstrak yang efektif untuk menyembuhkan luka insisi dan luka bakar.
Desain penelitian yang digunakan adalah Rancangan Acak
Kelompok (RAK) dengan ruang lingkup penelitian prospektif laboratorium eksperimental sungguhan yang bersifat komparatif. Penentuan jumlah hewan uji yang digunakan dihitung berdasarkan rumus Federer yaitu (n-1)(t-1) ≥15. Penelitian dilakukan dalam beberapa tahapan, yang dimulai dengan ekstrasi daun tanaman Botto’-botto (Chromolaena odorata (L.) dan pemekatan ekstrak; Penetapan konsentrasi ekstrak yang efektif untuk penyembuhan luka pada hewan uji; formulasi dan evaluasi mutu, stabilitas
fisik, dan cemaran mikroba sediaan.
Dari pengujian menunjukkan konsentrasi ekstrak daun Chromolaena odorata (L.) King & H.E. Robins dalam sediaan gel berpengaruh terhadap efek penyembuhan luka insisi dan luka bakar; sediaan gel yang mengandung ekstrak daun Chromolaena odorata (L.) dengan carbopol 940
konsentrasi 0,7% sebagai pembentuk gel memiliki karakteristik yang baik dan stabil secara fisika, dan sediaan gel dengan kandungan ekstrak daun Chromolaena odorata (L.) sebesar 0,1 % efektif menyembuhkan luka
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Characterization of contact parameters and fretting wear behavior of T-800 coating on Inconel 718
No full textFretting wear is a complex phenomenon that occurs at component interfaces that are subjected to low amplitude oscillation under high contact pressure.
In turbomachinery fretting also occurs at the blade tip interfaces where shrouds are machined. To diminish the fretting damage coatings are applied to the blade tips. The aim of this work is to study the wear mechanism
by point contact at room temperature and characterize the friction behavior and the fretting wear of Tribaloy T-800 coating, applied by plasma spray on an Incone718 superalloy. Some wear test of Tribaloy by pin-on-disc, ball-on-disc and block-on-ring can be found in literaure. Experiments were conducted with a self made test rig where a nominal spherical surface was
pressed against a flat surface of the same material . The mating surfaces were worn with an alternating relative displacement with an amplitude of 150
μm, at a frequency of 100 Hz for 5×106; 10×106; 15×106 wear cycles and two normal load. The hysteresis cycles, namely the tangential contact force against the relative displacement, were measured throughout the experiment and the contact parameters (friction coefficient and contact stiffness) as function of wear cycles were obtained. At the end of the wear process, the three-dimensional topography of mating surfaces were measured by focus variation technology and observed through a SEM analysis. Loss volume during the wear processes were obtained by topography measurements
Fretting Wear of T800 Coating in Aero-Engine Applications
No full textHigh cycle fatigue in blades is triggered by oscillating
forces. Devices such as shrouds, that exploit dry friction, are
commonly introduced in the blade assembly to reduce the blade
vibrations. If severe wear occurs, the effectiveness of the dry
friction damping decreases, vibrations increase, and the number
of cycles to failure of the blade diminishes. Mating surfaces in
shrouds undergo high loads combined with relative displacement
of low amplitude. This is the typical condition known as fretting.
Coatings are commonly applied on damping surfaces of turbine
blades to mitigate wear.
This study investigates the wear mechanism of contact
interfaces coated by Tribaloy® T-800, a coating greatly used in
aeroengines. The experimental campaign was performed with a
point contact test rig. The investigation was carried out using as
test parameters temperature, normal load and fretting
amplitude. Nine sets of parameters were analyzed at different test
durations. Friction coefficients were computed using the
hysteresis loops measured during the fretting tests. The worn
surfaces were measured by an optical equipment based on focus
variation and the volume losses were accurately measured. The
wear region was observed by scanning electron microscopy at
the end of each test.
At room temperature, the friction coefficient was found
substantially independent of the normal load. The wear rates at
room temperature were higher than at high temperature.
Observation of the worn surfaces by scanning electron
microscopy revealed several brittle cracks. The damage
mechanism changes from brittle (at room temperature) to ductile
(at high temperature). The volume loss as a function of the
dissipated energy was found independent of the normal load,
showing that dissipated energy is a better variable rather than
the number of wear cycles to show results of wear tests
Single chamber ICD with single-pass AV defibrillation lead. Outcome s of the ADAMO Italian Registry
No full text
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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