1,721,023 research outputs found
28. Marcello Fogolino, Madonna del Popolo incoronata da due angeli tra i santi Nicola di Bari, Giovanni Battista, Dorotea, Giuseppe e tre angioletti musicanti
27. Marcello Fogolino, Dio Padre benedicente tra due angioletti (cimasa); Madonna col Bambino in trono incoronata da due angioletti tra i santi Andrea e Pietro (pala); Vocazione dei santi Pietro e Andrea; Adorazione dei Magi; Martirio di san Pietro (predella)
21. Marcello Fogolino, Madonna col Bambino in trono tra i santi Filippo e Giacomo Maggiore
24. Marcello Fogolino, Annunciazione (architrave); Madonna del Latte incoronata da due angioletti tra i santi Agostino e Bernardino da Siena (pala); Santa Caterina d’Alessandria; Visione di sant’Agostino; Adorazione del Bambino; Predica di san Bernardino da Siena; Simonino da Trento (predella)
"Fradeli banditi quali habitano a Trento": pale trentine e amicizie friulane di Marcello Fogolino
Cerebral Blood Flow Thresholds in Acute Stroke Triage. Response to letters by Lee et al and Lev et al [5]
A discussion about the methodology used for systematic review and meta-analysis of cerebral blood flow threshold in ischemic strok
Discriminating between brain infarct and reversible brain ischaemia in acute stroke patients: A systematic review.
Background and Purpose—Cerebral blood flow (CBF) reduction below critical thresholds discriminates between irreversible infarct core, penumbra, and benign oligemia (penumbra that recovers spontaneously). Thresholds are based on animal studies, and their diagnostic accuracy in humans has never been established. The purpose of this study was to assess the evidence available on CBF thresholds for infarct core and penumbra in adult stroke patients.
Methods—Electronic database searching using Medline, Embase and the Cochrane Library, crosschecking of references, and contact with experts and authors of primary studies was used. Studies on adult stroke patients were included if they compared CBF measurements with a diagnostic gold standard (follow-up brain CT/MRI), and reported CBF thresholds. Two reviewers independently extracted the data and assessed study quality.
Results—A meta-analysis could not be carried out because of insufficient data. The optimal reported CBF thresholds varied widely, from 14.1 to 35.0 and from 4.8 to 8.4 mL/100 g per minute for penumbra and infarct core, respectively.
Conclusions—The use of CBF thresholds in commercial software for imaging methods cannot be recommended without further evaluation. (Stroke. 2006;37:1334-1339.
Cerebral blood flow thresholds for cerebral ischemia in traumatic brain injury. A systematic review
BACKGROUND:: Reduction of cerebral blood flow plays a crucial role in causing posttraumatic cerebral ischemia. However, the methodologic adequacy of studies from which currently used cerebral blood flow thresholds in traumatic brain injury have been derived has not been evaluated. OBJECTIVE:: To systematically evaluate the evidence available on cerebral blood flow thresholds and its methodologic adequacy in adults with traumatic brain injury. METHODS:: Included were primary studies on adults with traumatic brain injury in which cerebral blood flow thresholds were evaluated and reported, and follow-up brain computed tomography or magnetic resonance imaging was used as the gold standard for diagnosing the finally infarcted area. RESULTS:: Among the 53 diagnostic studies identified, 31 did not report any threshold value, whereas 20 studies used thresholds derived from the literature, mainly animal or clinical studies on ischemic stroke. One study measured cerebral blood flow thresholds, but did not use accepted neuroradiological criteria for the diagnosis of posttraumatic cerebral ischemia. The remaining study fulfilled all methodologic inclusion criteria, but was restricted to 14 patients with severe traumatic brain injury and cerebral contusion. This study proposed a cerebral blood flow threshold of 15 mL/100 mL/min, with sensitivity and specificity of 43% and 95%, respectively. CONCLUSIONS:: Cerebral blood flow thresholds for the diagnosis of posttraumatic cerebral ischemia are based on weak evidence, and cannot be recommended. © 2008 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins
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