1,721,076 research outputs found
Le zone industriali del Basso Padovano. Elementi strutturali per la rigenerazione urbana e territoriale
No full textLa dismissione del patrimonio industriale non dipende solamente da fattori edilizi (la dimensione del bene, la sua destinazione d’uso, il suo grado di conservazione), ma anche da fattori complessi che riguardano il sistema delle relazioni tra il bene ed il territorio, l’economia, la struttura sociale. Per questo motivo è necessario che il tema venga affrontato attraverso analisi conoscitive complesse che leggano sia gli aspetti qualitativi che quelli quantitativi. Solo attraverso queste letture sarà possibile comprendere a fondo le dinamiche per giungere a proposte di rigenerazione capaci di rispondere appieno alle dinamiche del reale
La regola della singolarità
No full textUna riflessione fra montagna e urbanistica, ossia la prassi urbanistica nei territori montani. Richiamando parallelamente il caso concreto del Piano Generale di Zona del Centro commerciale e turistico di San Martino di Castrozza. Il contributo si sofferma su alcuni aspetti maggiormente generali, di pianificazione e di organizzazione strategica del territorio montano: attraverso gli indirizzi e gli strumenti proposti dal nuovo PTRC del Veneto. La montagna veneta ha sviluppato propri sistemi insediativi che però comunque nel loro complesso hanno dovuto necessariamente relazionarsi con i sistemi insediativi planiziali di principale afferenza spaziale, territoriale e geografica. E' evidente quindi rilevare che anche il sistema insediativo storicamente sviluppato in ambito prealpino e alpino è anch'esso fortemente caratterizzato da fenomeni di accentuata dispersione
Mechanism of occupational asthma
No full textInhalation of agents in the workplace can induce asthma in a relatively small proportion of exposed workers. Like nonoccupational asthma, occupational asthma is probably the result of multiple genetic, environmental, and behavioral influences. It is important that occupational asthma be recognized clinically, because it has serious medical and socioeconomic consequences. Environmental factors that can affect the initiation of occupational asthma include the intrinsic characteristics of causative agents, as well as the influence of the level and route of exposure at the workplace. The identification of host factors, polymorphisms, and candidate genes associated with occupational asthma may improve our understanding of mechanisms involved in asthma. High-molecular-weight compounds from biological sources and low-molecular-weight chemicals cause occupational asthma after a latent period of exposure. Although the clinical, functional and pathologic features of occupational asthma caused by low-molecular-weight agents resemble those of allergic asthma, the failure to detect specific immunoglobulin E antibodies against most low-molecular-weight agents has resulted in a search for alternative or complementary physiopathologic mechanisms leading to airway sensitization. Recent advances have been made in the characterization of the immune response to low-molecular-weight agents. In contrast, the mechanism of the form of occupational asthma that occurs without latency after high-level exposure to irritants remains undetermined
Neutrophils and Asthma
No full textThe importance of inflammation in asthma has been recognized for a long time and recently proved in man and animal models. All inflammatory cells are probably involved in exacerbations of asthma. Neutrophils in particular are present in the airways during and after the spontaneous asthma attacks in man and during asthmatic reactions and airway hyperresponsiveness induced experimentally in man and animals. Depletion of neutrophils prevents these effects and repletion with neutrophils reconstitutes them. Moreover, the supernatant from stimulated human neutrophils causes transient hyperresponsiveness. However, neutrophils are not increased in stable asthmatics with hyperreactive airways and are not involved in airway hyperresponsiveness induced experimentally in some animals (e.g. guinea-pigs). The studies reviewed suggest that neutrophils may be involved in the transient increases of airway responsiveness associated with exacerbations of asthma, but not in the long-lasting hyperresponsiveness of stable asthmatics
Lack of increase or reduction in circulating platelet factor 4 and heparin-releasable platelet factor 4 in symptomatic patients with asthma.
No full textWe measured circulating platelet factor 4 (PF4) and heparin-releasable platelet factor 4 (HR-PF4) in 13 symptomatic patients suffering from bronchial asthma and in 10 matched normal controls. Neither a difference between patients and controls, nor a correlation between platelet count and HR-PF4 was found (PF4: controls 2.1 +/- 2.9; patients 3.6 +/- 4.4 ng/ml (n.s.); HR-PF4: controls 127 +/- 49, patients 101 +/- 34 ng/ml (n.s.). Therefore, the pathogenetic role of PF4 in the mechanism of bronchial asthma, elsewhere hypothesized, cannot definitely be established
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