4,059 research outputs found

    Development of Biocatalytic Processes in Japan and Germany: From Research Synergies to Industrial Applications

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    Gröger H, Asano Y, Bornscheuer UT, Ogawa J. Development of Biocatalytic Processes in Japan and Germany: From Research Synergies to Industrial Applications. Chemistry - An Asian Journal. 2012;7(6):1138-1153

    Possibilities and limitations of biotechnological plastic degradation and recycling

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    Wei R, Tiso T, Bertling J, O’Connor K, Blank LM, Bornscheuer UT. Possibilities and limitations of biotechnological plastic degradation and recycling. Nature Catalysis. 2020;3(11):867-871

    Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction

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    Scherkus C, Schmidt S, Bornscheuer UT, Gröger H, Kara S, Liese A. Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction. Biotechnology and Bioengineering. 2017;114(6):1215-1221

    UT Tyler Patriot Vol. 21 no. 2

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    The official newspaper for the University of Texas at Tyler from 1979 to 1993. Articles in this issue include: We Must Never Stop Trying to Find Peaceful Solutions -Eban; Caddy Shack Home for Graduate Student; Safe-D Promotes Safety, Auto Accidents Curbed; Highest Fall Enrollment Totals 4101 at UT Tyler; Stones Tickets Still Available; Campus Organizations Co-Sponsor Student/Faculty Reception Oct. 17; Think Again; There\u27s No Such Thing as a Little Freedom; Poll Reflects Optimism; The SA Beat; Registration Deadline Nears for Nov. 7 City, State Elections; UTT Drama Production Dining Room Opens Oct. 27; Dr. George Feifer Noted Author Explains Russian Life; Professor, Son Spend Year in Sister City ; Counseling Center Offers a Variety of Services; Kidd, Fitzgerald Win; SIFE Students Meet Saturday; Tennis Team Wins Championshiphttps://scholarworks.uttyler.edu/uttylerpatriot/1131/thumbnail.jp

    Opportunities and challenges for combining chemo- and biocatalysis

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    Rudroff F, Mihovilovic MD, Gröger H, Snajdrova R, Iding H, Bornscheuer UT. Opportunities and challenges for combining chemo- and biocatalysis. NATURE CATALYSIS. 2018;1(1):12-22.The past decade has seen a substantial increase in successful examples of the combination of chemo-and biocatalysis for multistep syntheses. This is driven by obvious advantages such as higher yields, decreased costs, environmental benefits and high selectivity. On the downside, efforts must be undertaken to combine the divergent reaction conditions, reagent tolerance and solvent systems of these 'different worlds of catalysis'. Owing to progress in enzyme discovery and engineering, as well as in the development of milder and more compatible conditions for operating with various chemocatalysts, many historical limitations can already be overcome. This Review highlights the opportunities available in the chemical space of combined syntheses using prominent examples, but also discusses the current challenges and emerging solutions, keeping in mind the fast progress in transition metal-, organo-, photo-, electro-, hetero- and biocatalysis

    Biocatalytic access to chiral polyesters by an artificial enzyme cascade synthesis

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    Schmidt S, Buechsenschuetz HC, Scherkus C, Liese A, Gröger H, Bornscheuer UT. Biocatalytic access to chiral polyesters by an artificial enzyme cascade synthesis. ChemCatChem. 2015;7(23):3951-3955.Chiral polyesters in general can be employed for versatile biomedical purposes, but in vitro enzyme catalyzed biocatalytic routes by a multiple-step cascade to make these functional biodegradable chiral polyesters have been hardly investigated. Recently, we developed an artificial three-step enzymatic cascade synthesis by combining an alcohol dehydrogenase (ADH), a Baeyer-Villiger monooxygenase (BVMO) and a lipase (CAL-A). Here, we extended this cascade for the synthesis of chiral methyl-substituted oligo-e-caprolactone derivatives to achieve both, the generation of chirality in a monomer and the subsequent polymerization. Several substrates were examined and provided access to functionalized chiral compounds in high yields (up to > 99%) and optical purities (up to > 99% ee). By subsequent enzymatic enantioselective ring opening of the enantiopure monomers, oligomeric lactones were successfully synthesized

    Copyright Issues Got You Down?: Updates from the Scholarly Communications Working Group

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    The use and creating of research are integral parts of faculty’s teaching and scholarship, but navigating the ins and outs of copyright issues, the allowances and exclusions, can be overwhelming. During this workshop, participants will hear about what UT Tyler’s Scholarly Communications working group has developed for faculty, including information relating to author rights, copyright, fair use, open access, creating access to faculty scholarship through Scholar Works at UT Tyler, and the use of open textbooks and other free course materials

    Intercom 1995 November 27

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    Campus Campaign Exceeds Goal, UT Tyler, TJC Music Groups to Perform, Repertory Plays Scheduled in December, Graduate Students Author AmeriCorps Grant, In The Spotlight, Alphi Chi Names Outstanding Faculty, Personnel Update, Service Recognition, Christmas Holiday Schedule

    Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone

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    Staudt S, Bornscheuer UT, Menyes U, Hummel W, Gröger H. Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology. 2013;53(4):288-292.The development of a biocatalytic process concept for ɛ-caprolactone, which directly converts cyclohexanol as an easily available industrial raw material into the desired ɛ-caprolactone in a one-pot fashion while only requiring air as sole reagent, is reported. The desired product ɛ-caprolactone was obtained with 94-97% conversion when operating at a substrate concentration in the range of 20-60mM. At higher substrate concentrations, however, a significant drop of conversion was found. Subsequent detailed studies on the impact of the starting material, intermediate and product components revealed a significant inhibition and partial deactivation of the BVMO by the product ɛ-caprolactone (in particular at higher concentrations) as well as an inhibition of the BVMO by cyclohexanol and cyclohexanone
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