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Retinal thickness reduction and layers involvement in different diseases visualized by SD-OCT
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Research of the feeder vessels in secondary choroidal neovascularization with age-related macular degeneration
No full textPhotocoagulation of the feeder vessels of choroidal neovascularization in age-related macular degeneration. Preliminary considerations on some cases.
No full textHyper-autofluorescence in outer retinal layers thinning
No full textPurpose. To evaluate if paracentral hyperautofluorescence (HAF) retinal regions, which can be occasionally found and analyzed by optical coherence tomography (OCT), were related to retinal layer changes and to detect which layer was involved. Methods. This is a cross-sectional and retrospective study. 648 OCT files were revised. OCTs that showed a paracentral HAF area by using the fundus autofluorescence imaging inHeidelberg Spectralis (Heidelberg Engineering, Germany) were selected. Then retinal layer morphology was analyzed observingOCT scans and a retinal thickness was measured.
Results. 31 patients were selected: 20 patients had chronic serous epitheliopathy (CSE), 8 patients had resolved central serous chorioretinopathy (CSC), and 3 patients wet age
related macular degeneration (ARMD). The HAF zones corresponded to areas of thickness reduction of the external hypo reflective band. In all these areas the retinal pigment epithelium was not atrophic and the neuroepithelium was more or less dystrophic. In particular the retinal thickness was 264 um, 232 um, and 243um in wet ARMD, CSE, and CSC, respectively; the reduction was significant ( < 0.01) compared to the same area of the other eye.
Discussion.The presence of HAF imaging might be mostly due a “window effect” rather than an accumulation of lipofuscin
Clinical assessment of retinal changes by spectral-domain OCT.
No full textPurpose: To evaluate optical coherence tomography changes in patients with retinal thinning at the posterior pole.
Methods: In this cross-sectional and retrospective study, 648 files were reviewed, and 67 patients were selected.
Optical coherence tomography images that showed an area with a retinal thickness reduction at the macular
region by using the Asymmetry Analysis Map in Heidelberg Spectralis were selected. The presence of hemisphere
asymmetry in the same eye and asymmetry between the paired eyes were calculated and used for the
analysis. Retinal thickness was measured in 3 different retinal areas (squares): (1) the area (square) involved by
the pathology (IA), (2) the specular area (square) in the opposite hemifield (SA), and (3) the corresponding IA
in the contralateral eye (CIA) (area used to recruit the patients). Retinal layer morphology was analyzed observing
the Spectralis screen.
Results: The thickness of the IA was 235.54 ± 39.95 μm (mean ± standard deviation), while it was 269.84 ± 36.16 μm
and 293.81 ± 37.52 μm for SA and CIA, respectively.
Conclusions: Different retinal layers could be involved in reduction of the retinal thickness: a reduction of the inner
layers was related to disease in which ciliary or retinal arterial vessel flow was involved, while a reduction of
the outer retinal layer was related to pathologies related to choroidal flow diseases
Increased fundus autofluorescence (AF) in retinal regions characterized by thickness reduction in outer retinal layers
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