67,453 research outputs found
Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery
No full textCopyright @ 2014 Booth et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poorly characterised compartment. In this study, we report that the nucleolar protein Ki-67 is required for the assembly of the perichromosomal compartment in human cells. Ki-67 is a cell-cycle regulated protein phosphatase 1-binding protein that is involved in phospho-regulation of the nucleolar protein B23/nucleophosmin. Following siRNA depletion of Ki-67, NIFK, B23, nucleolin, and four novel chromosome periphery proteins all fail to associate with the periphery of human chromosomes. Correlative light and electron microscopy (CLEM) images suggest a near-complete loss of the entire perichromosomal compartment. Mitotic chromosome condensation and intrinsic structure appear normal in the absence of the perichromosomal compartment but significant differences in nucleolar reassembly and nuclear organisation are observed in post-mitotic cells
C-testable modified-booth multipliers
No full textIn this paper the testability of modified-Booth array multipliers for standard cells based design environments is examined for first time. In such cases the structure of the cells may be unknown, thus Cell Fault Model (CFM) is adopted. Two C-testable designs are proposed. A design for an N-x x N-y. bits modified-Booth multiplier, which uses ripple carry addition at the last stage of the multiplication, is first proposed. The design requires the addition of only one extra primary input and 38 test vectors with respect to CFM. A second C-testable design is given using carry lookahead addition at the last stage which is the case of practical implementations of modified-Booth multipliers. Such a C-testable design using carry lookahead addition is for first time proposed in the open literature. This second design requires the addition of 4 extra primary inputs. One-level and two-levels carry lookahead adders, are considered. The C-testable design requires 61 test vectors for the former and 73 test vectors for the latter, respectively. The hardware and delay overheads imposed by both C-testable designs are very small and decrease when the size of the multiplier increases
Booth, Edwin
No full textCarte-de-visite of Edwin Booth from the United States Civil War period. Famous actor and brother of John Wilkes Booth, the man who assassinated President Lincoln
Rules, discretion and local responsibility : development control case studies in the urban community of Lyon.
No full textThe research presented in this thesis rests on the premise that the administrative and legal systems of France have a critical bearing on the way that decisions on applications for permissions to build are taken, and the nature of the
decisions themselves. In the knowledge that the French system of law offered a legalistic, regulatory franiework for planning policy and policy implementation, four
specific questions are posed: firstly about the relationship of plans to development control decisions; secondly about the effects of the system on applicants; thirdly about the possibilities for third parties to be involved in, and seek redress from, development control decisions and fourthly about the effects of the decentralisation of development control powers that has taken place since 1983. These questions are then located within a broader discussion of discretion, accountability and the management of uncertainty. The theoretical discussion of the first chapter paves the way for a more detailed presentation of the nature and origins of French local administration and French planning law and procedure which in turn lead to a case study of the 55 communes of the Urban Community of Lyon and eight studies of development control applications which are explored through an examination of the case file documents and interviews with participants. Two sets of conclusions are drawn from the study. The first set concerns the
effects of a legalised system on the making and implementation of planning policy. The first conclusion is that the legalistic approach of the French planning system
appears to create serious difficulties for finding an appropriate expression for policy. In part the problem is shown to be as much a question of ethos as of what is really
possible under the law, amid some examples of practice in Lyon show how flexibility is still possible even within a legalised system. The second conclusion is that once the
rules are departed from, the system offers no alternative means of testing policy in its specific application, although the use of non-statutory consultation meetings in Lyon has gone some way to meeting the problem. The third is that the pattern of zoning and regulations does not appear to help the maintenance of a planning strategy. The fourth is that a legalised system does not promote certainty for either administrators or applicants. The fifth is that a legalised system does not permit third parties to participate in the decision-making and ensures that objections are seen mainly as being about property values.
The second set of conclusions has to do with the question of the power to decide and the accountability of decision-makers. The first is that the legalised system, while offering potential for agency discretion, nevertheless appears to favour officer discretion which on the evidence of the case studies is rife. While offering mayors the possibility of tactical power, it appears to reduce the accountability for decisions taken. Moreover, the control of the legality of decisions is dependent equally upon the discretion of the prefect. The second is that the pattern of crossregulation within the French system of local government has ensured the continuity of dependencies between the principal actors in the planning system. The final
conclusion is that decentralisation has had relatively little effect on the balance of power. In the Lyon conurbation, COURLY would appear to be the principal
beneficiary of the new powers, which would suggest that more power will be concentrated in future at the local level, but that the power will not be any more susceptible to control by the electorate
Booth, John Wilkes
No full textCarte-de-visite of John Wilkes Booth from the United States Civil War period. American stage actor who assassinated President Lincoln
Letter from D. E. Wilson to C. H. Booth, Taylor, Texas, January 29, 1918
No full textA document from an extensive collection spanning four generations of the Woodward family that operated merchant pig iron companies in West Virginia and Alabama. The collection begins with Stimpson Harvey Woodward (S. H. Woodward), a native of Massachusetts, who moved from Pittsburgh to Wheeling, West Virginia in 1852. He had interests in an iron company as early as 1852 in West Virginia and began Alabama operations in 1869. The family business continued in Alabama until the death of S. H. Woodward's great-grandson in 1965
Angela Booth
No full textPhotograph used for a newspaper owned by the Oklahoma Publishing Company. Caption: "Fifth grader Angela Booth is all smiles as she anticipates her trip to Washington, D. C.
Tsacalakis (Antoine), Le Dodécanèse, étude de droit international ; Booth (C. D.) et Isabelle Bridge, Italy's Aegean Possessions
No full textJanin Raymond. Tsacalakis (Antoine), Le Dodécanèse, étude de droit international ; Booth (C. D.) et Isabelle Bridge, Italy's Aegean Possessions. In: Échos d'Orient, tome 28, n°154, 1929. p. 250
Letter from D. E. Wilson to C. H. Booth, Taylor National Bank, Taylor, Texas, February 11, 1918
No full textA document from an extensive collection spanning four generations of the Woodward family that operated merchant pig iron companies in West Virginia and Alabama. The collection begins with Stimpson Harvey Woodward (S. H. Woodward), a native of Massachusetts, who moved from Pittsburgh to Wheeling, West Virginia in 1852. He had interests in an iron company as early as 1852 in West Virginia and began Alabama operations in 1869. The family business continued in Alabama until the death of S. H. Woodward's great-grandson in 1965
Priorities and Principles for Investment in Aquaculture Research by NSW Department of Primary Industries
No full textThis review examined the characteristics of the main aquaculture industries in NSW with respect to current impediments to growth, market development and future opportunities. Within this context, it examined the nature, funding and impacts of the NSW Department of Primary Industries’ current and proposed investments in aquaculture R&D and industry development, as well as its alignment with DPI and industry priorities.aquaculture, research evaluation, public good, Agribusiness, Livestock Production/Industries, Research and Development/Tech Change/Emerging Technologies, Q160,
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