2 research outputs found
Investigation of furan metabolite BDApolyamine crosslinks in cell toxicity and carcinogenesis
No full textMentor: Lisa PetersonFuran is a product of incomplete combustion present in canned foods, tobacco smoke and exhaust fumes. It has been shown to be a liver toxicant and carcinogen in rodents. This project seeks to determine the toxic carcinogenic effect of furan in human liver cells as these remains unknown. Cis-2-butene-1,4-dial (BDA), a highly reactive breakdown product of furan, has been shown to form
stable crosslinks with polyamines and glutathione in vivo and in cell models. The
spermine and ornithine crosslinks were synthesized and purified using high pressure liquid chromatography and characterized using mass spectrometry and nuclear magnetic resonance. The synthesized crosslinks will be introduced into human liver cell cultures to study if these products of furan metabolism play a role in liver toxicity and carcinogenicity. These data will be combined with others to determine if furan is a human health concern.This research was supported by the Undergraduate Research Opportunities Program (UROP).Bonglack, Mildrede. (2012). Investigation of furan metabolite BDApolyamine crosslinks in cell toxicity and carcinogenesis. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/123471
Cotyledonoid dissecting leiomyoma in pregnancy: a case report
No full textCotyledonoid dissecting leiomyoma (CDL) is a rare variant of uterine leiomyoma characterized by intramural dissection within the uterine corpus and a distinctive gross appearance resembling the cotyledons of the placenta. Despite their alarming, sarcomatous appearance both macroscopically and radiographically, these tumors are typically associated with bland histologic findings. Approximately 70 cases of CDL have been described in the literature. This case represents the second described case of CDL in pregnancy, the first in which a pregnancy was carried to term. A 28-year-old primigravid was incidentally found to have a massive, exophytic growth of the uterus on ultrasound with concomitant 14-week intrauterine pregnancy. The pregnancy was monitored with serial growth ultrasounds. She was delivered at 37 weeks via Cesarean section. After being lost to follow-up, the patient presented 2.5 years later with worsening abdominal fullness and persistent uterine mass
