1,721,054 research outputs found
Synthesis and biological evaluation of chlofibrate-like drugs on voltage-gated chloride channels (CLC)
No full textValutazione della tecnica RP-LC-ESI-MS per l’identificazione dell’isoniazide in latte bovino
No full text
Assessment of dietary intake of Patulin from baby foods.
No full textPatulin is a mycotoxin produced by microscopic fungi belonging to the Penicillium and Aspergillus genera, frequently detectable in moldy fruits and their derivatives fruit products. The EC Regulation 1881/06 has imposed the limit for the presence of patulin equal to 10 mu g/kg or 10 mu g/L in baby food on the basis of a PMTDI of 0.4 mu g/kg bw set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). A total of 120 homogenized baby foods were analyzed to evaluate the exposure of baby and children to patulin through the consumption of these products. None of examined samples has shown a toxin concentration above the limit imposed by the law, however a PAT concentration equal to 9 mu g/kg was found in 22 samples, slightly below the fixed limit. The presence of patulin in marketed baby food can be regarded as a parameter indicative of the quality of raw materials used
Determination of ochratoxin A in eggs and target tissues of experimentally drugged hens using HPLC–FLD
No full textOchratoxins are fungal secondary metabolites that may contaminate various foods and beverages. The
intake of ochratoxins by humans may result in typical syndromes (nefrotoxicity, carcinogenity, teratogenicity
and immunotoxicity) and has been associated with Balkan Endemic Nephropathy (BEN). In this
study we evaluated the effects of accumulation of ochratoxin A throughout the chain production of eggs,
by investigating the dynamics of OA accumulation in eggs placed by laying hens experimentally exposed
to OA.
It was demonstrated that after exposure at the concentrations admitted by the current European legislation
(100 lg/kg) and at concentrations 20-folds as much the European Legislation limit (2000 lg/kg),
OA was not detectable in the eggs, although a number of eggs were found to have altered structure or
conformation and/or pathological lesions.
Monitoring fungal contamination and toxins in animal feeds is necessary to guarantee animal health
and to prevent the risk of decreased productions in livestock animals
Ochratoxin A in laying hens: high-performance liquid chromatography detection and cytological and histological analysis on target tissues
Full text linkOchratoxins are fungal secondary metabolites that contaminate grains, legumes, coffee, dried fruits, beer,
wine, and meat. Ochratoxins are considered powerful nephrotoxins, carcinogens, teratogens, and immunotoxins
in rats and likely in humans. In 2006 during a pilot program of Hazard Analysis Critical Control Point in the
Apulian region, Southern Italy, ochratoxin A (OA) was detected in commercial feed for laying hens in 2 farms.
The OA-contaminated feed had been administered to animals for at least 2 mo. Analysis by HPLC with
fluorometric detection of the tissues of 4 layer hens that displayed gross and microscopical lesions identified
OA in the kidney (8.7 to 16.9 g/kg, average 13.65 ± 3.58 g/kg) and liver (3.7 to 5.1 g/kg, average 4.43
± 0.64 g/kg) but not in the other tissues
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