247 research outputs found
Finding Our Hue
No full textAuthor: Abrianna Gill | Illustrator: Lilliana Guerra | Editor: Jacquelyn Miles | Designer: Hugo ZhengBlue is faced with a choice: Follow their dreams and let down their parents, or follow their parents’ wishes and let down themselves. When different colors meet, will they collide, or mix to create a new hue
Human trafficking and migration: Interview with Jacquelyn Meshelemiah
No full textDr. Jacquelyn C.A. Meshelemiah is a Licensed Social Worker (LSW). She earned her Bachelor of Science in Social Work (BSSW), Master of Social Work (MSW), and Doctorate (PhD) from the College of Social Work, of The Ohio State University, USA. Dr. Meshelemiah has taught numerous courses across the curricula, but now exclusively teaches Assessment & Diagnosis in Clinical Social Work Practice, as well as Human Trafficking. She is the author and co-author of numerous publications, such as “Human sex trafficking” and, her latest, “Human rights perspectives in social work education and practice”. Has also done a series of presentations and trainings at the university, local, national, and international levels. Her primary research agenda centres on social justice, human rights, and anti-trafficking work. She has a crosscomparative analysis of human trafficking in Ghana, Uganda, Ethiopia, England, Mexico, Canada, Costa Rica, and the United States
A MAPK/c-Jun-mediated switch regulates the initial adaptive and cell death responses to mitochondrial damage in a neuronal cell model
No full textParkinson's disease (PD) is defined by the progressive loss of dopaminergic neurons. Mitochondrial dysfunction and oxidative stress are associated with PD although it is not fully understood how neurons respond to these stresses. How adaptive and apoptotic neuronal stress response pathways are regulated and the thresholds at which they are activated remains ambiguous. Utilising SH-SY5Y neuroblastoma cells, we show that MAPK/AP-1 pathways are critical in regulating the response to mitochondrial uncoupling. Here we found the AP-1 transcription factor c-Jun can act in either a pro- or anti-apoptotic manner, depending on the level of stress. JNK-mediated cell death in differentiated cells only occurred once a threshold of stress was surpassed. We also identified a novel feedback loop between Parkin activity and the c-Jun response, suggesting defective mitophagy may initiate MAPK/c-Jun-mediated neuronal loss observed in PD. Our data supports the hypothesis that blocking cell death pathways upstream of c-Jun as a therapeutic target in PD may not be appropriate due to crossover of the pro- and anti-apoptotic responses. Boosting adaptive responses or targeting specific aspects of the neuronal death response may therefore represent more viable therapeutic strategies
Measles virus causes immunogenic cell death in human melanoma
No full textNoOncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response
Not Too Late: Changing the Climate Story From Despair to Possibility
No full textNot Too Late brings strong climate voices from around the world to address the political, scientific, social, and emotional dimensions of the most urgent issue human beings have ever faced. Accessible, encouraging, and engaging, it\u27s an invitation to everyone to understand the issue more deeply, participate more boldly, and imagine the future more creatively. In concise, illuminating essays and interviews, Not Too Late features the voices of Indigenous activists, such as Guam-based attorney and writer Julian Aguon; climate scientists, among them Jacquelyn Gill and Edward Carr; artists, such as Marshall Islands poet and activist Kathy Jtil-Kijiner; and longtime organizers, including The Tyranny of Oil author Antonia Juhasz and Emergent Strategy author adrienne maree brown. Shaped by the clear-eyed wisdom of editors Rebecca Solnit and Thelma Young Lutunatabua, and enhanced by illustrations by David Solnit, Not Too Late is a guide to take us from climate crisis to climate hope. Contributors include Julian Aguon, Jade Begay, adrienne maree brown, Edward Carr, Renato Redantor Constantino, Joelle Gergis, Jacquelyn Gill, Mary Annaise Heglar, Mary Ann Hitt, Roshi Joan Halifax, Nikayla Jefferson, Antonia Juhasz, Kathy Jetnil Kijiner, Fenton Lutunatabua & Joseph Sikulu, Yotam Marom, Denali Nalamalapu, Leah Stokes, Farhana Sultana, and Gloria Walton.https://digitalcommons.library.umaine.edu/fac_monographs/1324/thumbnail.jp
Jealous Men but Evil Women: The Double Standard in Cases of Domestic Homicide
No full textIn 1989, Sarah Thornton killed her abusive husband with a knife, after years of abuse and threats to her daughter. She was convicted of murder and sentenced to life imprisonment. Also in 1989, Kiranjit Ahluwalia soaked her husband’s bedclothes with petrol and set them alight. He died from burns 10 days later, and she was subsequently convicted of murder and sentenced to life in prison.
In 1991, Joseph McGrail kicked his alcoholic common-law wife to death whilst she lay unconscious. He walked free from court, the judge telling him that “this lady would have tried the patience of a saint”. In 1992, Les Humes told a court that he “saw a red mist” after his wife admitted loving someone else. He fatally stabbed her whilst their teenage children struggled with him. He was convicted of manslaughter due to provocation and was imprisoned for 7 years.
Double standards in judicial processes are notorious. Chivalric justice is the case in which women are given lighter sentences for similar offences to men. This does not apply in the case of domestic homicide, where women are seen as evil and calculating when killing a spouse, men are seen as provoked beyond reason. Women who kill husbands do so with weapons that they need to acquire, men do it with their hands or weapons that are immediately available. So it is seems the defence of crime passionnel is reserved for men; women, it is implied, premeditate the murder of abusive husbands, and are justifiably punished. This paper explores the double standard in uxoricide vs. mariticide, and why it appears that killing a wife is justified and killing a husband is evi
MULTIMORBIDITY IN OLDER ADULTS: CAN DISEASE CLUSTER PREDICT DEPRESSION SEVERITY?
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in Innovation in Aging following peer review. The version of record Minahan, Jacquelyn. “MULTIMORBIDITY IN OLDER ADULTS: CAN DISEASE CLUSTER PREDICT DEPRESSION SEVERITY?.” Innovation in Aging vol. 3,Suppl 1 S393–S394. 8 Nov. 2019, doi:10.1093/geroni/igz038.1450 is available online at: https://doi.org/10.1093/geroni/igz038.1450.
This work is licensed under a Creative Commons Attribution 4.0 International License.Multimorbidity, defined as the co-occurrence of two or more chronic conditions, is positively correlated with depression severity among older adults. However, few studies have compared depression outcomes by disease cluster. To address this gap, secondary data analyses were performed using data from the National Social Life, Health, and Aging Project (NSHAP), Wave 2. For the purpose of this study, disease clusters are composed of conditions that implicate similar body systems (e.g., musculoskeletal system, cardiovascular system). Participants reported an average of 2.69 (+/- 1.97) chronic conditions. Multimorbidity and depressive symptom severity, as measured by the Center for Epidemiological Studies – Depression, Iowa Form (CES-D) were positively associated (p<0.001). Individual disease clusters, age, self-identifying as female, and lower educational attainment were predictive of depressive symptom severity (p<0.001). Findings support the necessary inclusion of social determinants (health status, gender, education, age) in the conceptualization of health and health outcomes within an aging population
Enhancing Inferential Abilities in Adolescence: New Hope for Students in Poverty
No full textThe ability to extrapolate essential gist through the analysis and synthesis of information, prediction of potential outcomes, abstraction of ideas, and integration of relationships with world knowledge is critical for higher-order learning. The present study investigated the efficacy of cognitive training to elicit improvements in gist-reasoning and fact recall ability in 556 public middle-school students (grades seven and eight), versus a sample of 357 middle school students who served as a comparison group, to determine if changes in gist-reasoning and fact recall were demonstrated without cognitive training. The results showed that, in general, cognitive training increased gist-reasoning and fact recall abilities in students from families in poverty as well as students from families living above poverty. However, the magnitude of gains in gist-reasoning varied as a function of gender and grade-level. Our primary findings were that seventh and eighth grade girls and eighth grade boys showed significant increases in gist-reasoning after training regardless of socioeconomic status. There were no significant increases in gist-reasoning or fact recall ability for the 357 middle school students who served in the comparison group. We postulate that cognitive training in middle school is efficacious for improving gist-reasoning ability and fact recall in students from all socioeconomic levels
Scholar to Discuss Civil Rights and Why They Matter
No full textAuthor, researcher Jacquelyn Down Hall to lecture Sept. 2
Forum: Jacquelyn Dillon and the Development and Promotion of Heterogeneous String Class Teaching Methods in the United States
No full text This historical study was primarily focused with the influence of Jacquelyn Dillon on string music education in the United States, and more specifically, her role in the use and promotion of heterogeneous string classroom teaching methods. Although this study briefly covers Dillon's childhood and education, the primary research questions centered around the regional and national aspects of her career, and the impact of these events on string music education in the United States. Having served as a public-school educator, clinician, conductor, author, professional cellist, music industry representative, and teacher trainer, Dillon dedicated nearly every aspect of her more than 50-year career to the advancement of string music education in the United States. One of her most important contributions, however, involves her use and promotion of heterogeneous string classroom teaching methods. </jats:p
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