1,721,094 research outputs found
Recent advances and conceptual changes in the classification of neuroendocrine tumors of the thymus
No full textAbstract
Neuroendocrine tumors of the thymus (TNET) are exceedingly rare neoplasms. Their histomorphology is identical to neuroendocrine tumors elsewhere in the body (in particular the lungs) and bears no similarity with thymomas and thymic carcinomas. Recent molecular findings have profoundly changed our perception of these tumors and may impact future histological classification systems.Projekt DEA
New methods at the transition from research to routine diagnostics
No full textHintergrund:Die Pathologie, traditionell auf Klassifikation und Diagnose fokussiert, entwickelt sich durch neue Technologien kontinuierlich weiter. Fortschritte in Proteomik, Epigenetik, Multiplex-Gewebefärbung und 3D-Bildgebung erweitern die Möglichkeiten der klassischen Morphologie.Ziel der Studie:Ziel dieser Studie ist es, zu untersuchen, wie moderne Technologien die diagnostische Genauigkeit und die resultierende Therapieauswahl verbessern können und wie sie in die pathologische Routinediagnostik integriert werden können.Materia und Methoden:Es wurden aktuelle Studien zu Proteomik, Epigenetik, Multiplex-Gewebefärbung und 3D-Gewebe-Bildgebung analysiert, um deren Anwendung und Herausforderungen in der klinischen Implementierung zu bewerten.Ergebnisse:Die Analyse zeigt erhebliches Potenzial für die pathologische Diagnostik. Proteomik ermöglicht ein tieferes Verständnis der molekularen Tumorarchitektur, während Epigenetik und 3D-Genomarchitektur neue Einblicke in genetische Regulation und Tumorheterogenität geben. Multiplex-Gewebefärbung und 3D-Gewebe-Bildgebung verbessern die räumliche Gewebeanalyse.Diskussion:Trotz des Potenzials zur Verbesserung der Diagnostik behindern hohe Kosten, technische Komplexität und fehlende Standardisierung die Integration in die klinische Praxis. Dennoch bieten diese Technologien vielversprechende Ansätze zur Optimierung der Diagnostik und Therapieauswahl. Forschung und interdisziplinäre Zusammenarbeit sind entscheidend, um diese Innovationen in die klinische Routine zu integrieren.Background:Pathology, traditionally focused on classification and diagnosis, is continuously evolving through new technologies. Advances in proteomics, epigenetics, tissue staining, and 3D imaging expand the possibilities of classical morphology.Aim of the study:The aim of this study was to investigate how modern technologies can improve diagnostic accuracy and therapy selection and how they can be integrated into pathologic routine diagnostics.Materials and methods:Recent studies in proteomics, epigenetics, multiplex tissue staining, and 3D tissue imaging were analyzed to assess their application and the challenges of clinical implementation.Results:The analysis shows significant potential for pathologic diagnostics. Proteomics provides a deeper understanding of the molecular architecture of tumors, while epigenetics and 3D genome architecture offer new insights into genetic regulation and tumor heterogeneity. Multiplex tissue staining and 3D tissue imaging improve spatial tissue analysis.Discussion:Despite the potential to improve diagnostics, high costs, technical complexity, and lack of standardization hinder integration into clinical practice. Nevertheless, these technologies offer promising approaches for optimizing diagnostics and therapy selection. Research and interdisciplinary collaboration are crucial to successfully integrating these innovations into routine clinical practice
The prognostic capacities of CBP and p300 in locally advanced rectal cancer
No full textCREB-binding protein (CBP) and p300 represent histone acetyltransferases (HATs) and transcriptional coactivators that play essential roles in tumour initiation and progression. Both proteins are generally thought to function as tumour suppressors, although their distinct roles in colorectal cancer (CRC) remain inconsistent and ambiguous. Thus, we analysed the expression of these two HATs in human tissue samples from patients with locally advanced rectal cancer via immunohistochemistry and evaluated their potential impacts on future CRC diagnosis and treatment
Increased expression of FBW7 may improve the prognosis of lung adenocarcinoma after pemetrexed chemotherapy by transforming the epithelial-to-mesenchymal process
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Hepatic arterial infusion with nanoliposomal irinotecan leads to significant regression of tumor size of colorectal liver metastases in a CC531 rat model
No full textIdentification of a novel prognostic signature based on vitamin metabolism clustering-related genes in lung adenocarcinoma
No full textSyk and Btk Transduce Survival and Proliferation-Inducing Signals By Activating Distinct Signaling Pathways and Transcriptional Programs in AML Cells
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