4,518 research outputs found
Slipper vi nogensinde af med coronavirus?
No full textI dette afsnit af ”Sundhedstegn” handler det om coronavirus/COVID-19. Vi skal finde ud af, hvad vi har lært om coronavirus indtil nu – og vi skal høre eksperternes bud på, hvor langt vi er med udviklingen af en vaccine. Endelig skal vi dykke ned i noget af den forskning i at finde effektive behandlinger, som foregår på blandt andet Aalborg Universitetshospital.Gæsterne denne gang er professor Henrik Nielsen og afdelingslæge Jacob Bodilsen fra Infektionsmedicinsk Afdeling på Aalborg Universitetshospital
Slipper vi nogensinde af med coronavirus?
No full textI dette afsnit af ”Sundhedstegn” handler det om coronavirus/COVID-19. Vi skal finde ud af, hvad vi har lært om coronavirus indtil nu – og vi skal høre eksperternes bud på, hvor langt vi er med udviklingen af en vaccine. Endelig skal vi dykke ned i noget af den forskning i at finde effektive behandlinger, som foregår på blandt andet Aalborg Universitetshospital.Gæsterne denne gang er professor Henrik Nielsen og afdelingslæge Jacob Bodilsen fra Infektionsmedicinsk Afdeling på Aalborg Universitetshospital
Optimization of antiviral dosing in Herpesviridae encephalitis: a promising approach to improve outcome?
No full textBackgroundDespite established antiviral therapy for herpes simplex virus, varicella zoster and cytomegalovirus encephalitis, the outcome remains poor.ObjectivesTo assess pharmacokinetic (PK) and pharmacodynamic (PD) data of antiviral drugs in the central nervous system (CNS) to optimize the treatment of Herpesviridae encephalitis.SourcesPUBMED search 1950 to September 2024, terms (1) “encephalitis” and (“HSV” or “VZV” or “CMV”) or (2) cerebrospinal and (“(val)acyclovir” or “(val)ganciclovir” or “foscarnet” or “cidofovir”).ContentAntivirals against herpes viruses apparently act in a time-dependent manner. To suppress viral replication, drug concentration in the extracellular space at the site of the infection should be kept above the concentrations active in cell cultures for 24 h/d. Most data reflect delayed drug entry into lumbar cerebrospinal fluid (CSF). Ratios of the areas of the concentration/time curves (AUC) in CSF and serum (AUCCSF/AUCS) of acyclovir, ganciclovir and foscarnet are 0.15−0.3 in the absence of meningeal inflammation and increase in severe meningoencephalitis. Elimination half-lives (t1/2β) are longer in CSF than in plasma. CSF concentrations are rough approximations of drug concentrations in the cerebral extracellular fluid. Lumbar CSF concentrations are usually higher than ventricular or cisternal CSF concentrations tending to overestimate cerebral extracellular fluid concentrations. Provided the availability of adequate measurements in individual CNS compartments, antiviral concentrations and efficacy may be predicted by future PK/PD modelling. Probenecid holds the potential to reduce the efflux of antiviral drugs from the CNS.ImplicationsThe long t1/2β of antiviral drugs in CSF suggest relatively uniform steady state CSF levels at dosing intervals ≤12h and accumulation after repeated dosing. Probenecid is of unproven utility. To rapidly attain effective concentrations in the infected tissue, physiologically based pharmacokinetic and PK/PD modelling may be helpful. Until reliable PK/PD data are available, doubling the first dose should be considered
Jacob of Sarug's Homily on Tamar (Gen 38)
No full textThis small volume contains an edition (from Vatican ms. 117) of Jacob of Sarug’s homily on Tamar (420 lines long). The full title is “On Tamar and on the Mystery of the Church.” The biblical narrative on which the poem is based (Gen 38) gives Jacob the opportunity to discuss various women in the early part of biblical history and in Jesus’ lineage, as well as the fact that a woman who is called a prostitute is in that lineage. Jacob explains how Scripture’s language is used in this regard
Jacob Wassermann.
No full textOne of several renderings of the German author Jacob Wassermann by the painter and illustrator Suzanne Carvallo-Schülein.Digital ImageArtwork
Jacob of Serugh's Homilies on the Spectacles of the Theatre
No full textThis fascinating volume contains excerpts from four otherwise unedited (and untranslated) homilies from Jacob of Sarug on the theatre. These homilies, extant only in a single manuscript (BM Add. 17158), which is unfortunately poorly preserved, are unique for the light they cast on the Greek theatre in the Byzantine period. In this article, originally published in Le Muséon 48 (1935), Moss gives a substantive introduction to the selections presented from these homilies, and then presents the texts in Syriac and in English translation. Scholars and readers interested in Syriac literature, and in Jacob of Sarug in particular, as well as students of the history of the theatre, will find this work of great interest.Translated into English from the Syriac text
Jacob Viner’s Reminiscences from the New Deal (February 11, 1953)
Get PDFThis paper presents and reproduces an unpublished oral history interview given by Jacob Viner in 1953. The interview released by Viner for the Columbia Oral History Project gives us a valuable opportunity to throw light on his advisory activity during the New Deal Era. In our introduction we attempt to make a critical appraisal of Viner's reminiscences and to state the contribution they can provide to our general knowledge of the period. In addition, we also attempt to find out some biographical and interpretative elements useful to understand Viner’s own vision and his contribution to important economic policy processes during the New Deal.
Jacob of Serugh on the Eucharist: Homilies 22 and 95
No full textIn the two articles reprinted here, Dom Hugh Connolly offers an English translation of two homilies from Jacob of Serugh dealing with the Eucharist. Connolly used the Syriac text of Bedjan’s edition of Jacob’s homilies (also available from Gorgias Press), homilies 22 and 95 in that edition. A short selection from homily 53 is also translated because of its related subject matter. Connolly gives an introduction to each homily and includes some explanatory notes to the texts. These translations originally appeared in The Downside Review, nos. 27 (1908) and 29 (1910).Translated into English from the Syriac text of Bedjan’s edition of Jacob’s homilies.These translations originally appeared in The Downside Review, nos. 27 (1908) and 29 (1910)
Gebißbuch Oder Kurtzer und Gründlicher Bericht/ von Gebiß und Zeumung der Pferd : sampt deroselben unterschiedlichen Würckung/ auch wie dieselben nützlich und nach gelegenheit der Pferde zugebrauchen sein / Allen ... Standes Personen/ und dieser Kunst Liebhabern zu Ehren ... verfaßt/ und in offnen Druck gegeben/ Durch Christoff Jacob Lieb
No full textJacob Roman Commentary on Aristotle's _Physics_ : 218b10 to 223a23
No full textThe author Jacob Roman (Parr) provides commentary and line by line analysis of 218b10 through 223a23 , which is of Aristotle's Physica .
written in 2023
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