1,721,093 research outputs found
Radiological mimics of cerebral microbleeds following endovascular aneurysm treatment: Implications for cerebral amyloid angiopathy diagnosis
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The association between statins and telomere shortening
No full textStatins are well-established drugs for primary and secondary prevention of cardiovascular diseases. Many statin cholesterol-lowering independent actions, known as 'pleiotropic effects', have been identified in different cell types, including modulation of inflammation, oxidative stress, apoptosis, cell proliferation, immune response and platelet aggregation. Recent evidence suggested an additional pleiotropic effect of statins on cellular senescence mediated by their interaction with telomere maintenance system. In this special report, we will present the most important findings regarding the association between statins therapy and telomere dynamic
Telomerase activation: A potential key modulator for human healthspan and longevity
No full textThe elderly population is increasing progressively. Along with this increase the number of age related diseases, such as cardiovascular, neurodegenerative diseases, metabolic impairment and cancer, is also on the rise thereby negatively impacting the burden on health care systems. Telomere shortening and dysfunction results in cellular senescence, an irreversible proliferative arrest that has been suggested to promote organismal aging and disabling age-related diseases. Given that telomerase, the enzyme responsible for maintaining telomere lengths, is not expressed at levels sufficient to prevent telomere shortening in most of our cells, telomeres progressively erode with advancing age. Telomerase activation, therefore, might serve as a viable therapeutic strategy to delay the onset of cellular senescence, tissue dysfunction and organismal decline. Here we analyze the more recent findings in telomerase activation as a potential key modulator for human healthspan and longevity
Perspective: Dietary Protein Needs of Elderly People: Protein Supplementation as an Effective Strategy to Counteract Sarcopenia
No full textNutrition and lifestyle in healthy aging: the telomerase challenge
No full textNutrition and lifestyle, known to modulate aging process and age-related diseases, might also affect telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation in stem cells and potentially in other cells by diet and lifestyle interventions may represent an intriguing way to promote health-span in humans
Letter to "Statin Use Is Associated With Reduced Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases"
No full textA narrative review on mild behavioural impairment: an exploration into its scientific perspectives
No full textIn clinical practice, the admission of patients with late-onset psychological and behavioural symptoms is frequent, regardless of the presence or absence of cognitive decline. These symptoms commonly occur in the prodromal stage of dementia and can precede the onset of dementia. While the concept of Mild Cognitive Impairment (MCI) -which is defined as a level of cognitive impairment insufficient to impact daily functioning- is well established, the notion of Mild Behavioural Impairment (MBI) is not yet widely recognized. However, studies have demonstrated that the presence of MBI in both cognitively normal patients and individuals with MCI is associated with an increased risk of dementia progression. Thus, MBI may serve as a neurobehavioral indicator of pre-dementia risk states. This narrative review aims to discuss the evolution of the term, the relevant clinical aspects, and potential biomarkers that may contribute to the clinical definition of MBI. The objective is to assist clinicians in recognizing the diagnosis and differentiating it from psychiatric syndromes, as well as identifying possible etiologies of neurodegeneration
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