1,721,032 research outputs found
Variation of mandibular radiomorphometric indices in metastatic bone cancer patients undergoing antiresorptive treatment: a prospective study
No full textIntroduction The aim of this study was to identify and evaluate the changes of oral health and panoramic radiograph indexes in cancer patients that have been administered antiresorptive drugs. Materials and methods Subjects who had a diagnosis of cancer with bone metastasis that were about to start antiresorptive therapy with denosumab or zoledronic acid were included. A preliminary dental clinical assessment, together with a panoramic radiograph, was performed at T0 to prevent the onset of Medication related osteonecrosis of the jaw (MRONJ) and T1 (1 year follow up). In order to calculate at both T0 and T1 the mandibular cortical width (MCW), the panoramic mandibular index (PMI), and the mandibular cortical index (MCI), panoramic radiographs were analyzed by a single operator. Results Thirty-three subjects with a mean age of 59.9 years were included in the study. A significant reduction in the PMI value from T0 to T1 (p = 0.00236) and a significant variation from T0 to T1 for MCI (p < 0.05) were observed. Conclusions Radiomorphometric indices could represent a promising field of research that can take advantage from the easy detectability in dental panoramic radiographs. Further research is needed to explore the possible role of PMI and MCI in bone cancer patients
The role of mechanical stretching in the activation and localization of adhesion proteins and related intracellular molecules
Full text linkChondrogenic induction of human mesenchymal stem cells using combined growth factors for cartilage tissue engineering
No full text
Biological effects of RGD and SIKVAV grafted peptides: Different strategies to improve bioactivity on PLLA to guide cellular contractile phenotype
No full textMULTIBOCK POLYURETHANES IN BIOMEDICAL APPLICATIONS: FINE TUNING OF DEGRADATION NAD BIOMIMETIC PROPERTIES
No full textThe role of the inflammatory response in tissue regeneration: new prospective in materials for cardiovascular application
No full text
New thermoplastic elastomer triblock copolymer of PLLA for cardiovascular tissue engineering: Annealing as efficient tool to tailor the solid-state properties
No full textA new high molecular weight aliphatic copolyester of PLLA characterized by a ABA triblock architecture was successfully synthesized by ring opening polymerization, using as initiator a low molecular weight hydroxyl terminated random copolymer of PBS, poly(butylene/triethylene succinate). To increase the final polymer molecular weight, thus ensuring both good processability and mechanical properties, chain extension reaction has been performed with hexamethylene diisocyanate (HDI) as chain extender. All the synthetic steps have been carried out in solvent-free conditions. Specifically, the A block consists of LLA sequences, whereas the B one is an aliphatic biodegradable and biocompatible random copolyester of poly(butylene succinate) containing “PEG-like” moiety. The so-obtained material was first characterized by the molecular point of view and then, prior to further characterization, subjected to two different annealing treatments. Annealing revealed to be an efficient tool to control the kind and amount of crystalline phase developed by the material, as confirmed by WAXS structural analysis, and to tailor the mechanical properties, typical of thermoplastic elastomers. Thermal treatment was found to affect also the mechanism of polymer degradation under physiological conditions. Last, but not least, in order to explore the possible use of such new PLLA-based copolymer in vascular tissue engineering, preliminary biocompatibility tests, using endothelial cells, were carried out
- …
