196,562 research outputs found
Giftighet av avfallsvann fra polyesterproduksjon (Alf Bjerke A/S) overfor fisk
No full textAlf Bjerke A/
Preliminary project Fv.841: Ringvålvegen pedestrian sidewalk and bycicle lane
No full textBacheloroppgave - Høgskolen i Sør-Trøndelag, Avdeling for teknologiEn ny gang- og sykkelveg fra Ringvålvegen fra like vest for Hestsjøen til der Tunellvegen krysser Ringvålvegen er prosjektert. Vegen som går her er stedvis uoversiktlig og trafikksikkerheten for myke trafikanter er dårlig. Derfor vil det være behov for en gang- og sykkelveg for å bedre trafikksikkerheten til myke trafikanter. Samtidig vil veglinja legges om noen plasser, slik at det blir plass til gang- og sykkelvegen og man bedrer sikten på steder med dårlig oversikt.
Det skal utarbeides tegninger som beskriver detaljer fra prosjekteringen, samt en rapport der valgene blir forklart. Det skal også produseres en reguleringsplan
Quantifying cellular parameters across the murine brain: New practices for integrating and analysing neuroscience data using 3D brain atlases
No full textEfforts to advance our understanding of the brain has led to an exponentially growing number of publications. However, research reporting practices are often insufficient for independent researchers to interpret and replicate findings, and underlying data are rarely made available. This hampers efforts to compare, integrate and re-use data from different studies.
Bjerke and colleagues aimed to develop new standards and workflows to facilitate data integration in neuroscience. They defined new standards for reporting anatomical locations in the murine brains, and showed how new methods to spatially define data in three-dimensional brain reference atlases can facilitate integration of data from multiple studies. They further built a database of published quantitative data from the murine basal ganglia, demonstrating how such data can be collected and compared. Lastly, they combined spatial registration of microscopic images to brain atlases with semi-automatic image analysis to quantify cell numbers and densities across murine brains. The work presented in this thesis together demonstrates how neuroscience data can be organized, integrated, and shared to facilitate their re-use
Hypotrachyna densirhizinata Hale 1975
No full textH. densirhizinata (Kurok.) Hale (1975: 31) One large colony was discovered on a north-facing rock wall in Torres del Paine National Park. The specimens contain atranorin, α-alectoronic acid and cf. α-collatolic acid. In the study area it has previously only been reported from Puerto Yartou in Chilean Tierra del Fuego (Hale & Kurokawa 1968). Specimen examined: CHILE. XII REGIÓN DE MAGALLANES: Parque Nacional Torres del Paine, between Lago Grey and Lago Pehoe, 200 m S of ‘elevation 269’, 51 ° 06’S, 73 ° 09’W, 150 m, on a vertical, north-facing cliff wall, ass. with Parmotrema reticulata and Normandina pulchella, 11 Mar 1998, Elvebakk, A. 98:472 & Bjerke, J.W. (TROM, SGO).Published as part of Elvebakk, A., Bjerke, J. W. & Støvern, L. E., 2014, Parmelioid lichens (Parmeliaceae) in southernmost South America, pp. 1-30 in Phytotaxa 173 (1) on page 8, DOI: 10.11646/phytotaxa.173.1.1, http://zenodo.org/record/514271
Parmotrema reticulatum Choisy 1952
No full textP. reticulatum (Taylor) Choisy (1952: 175) Reported from Argentinian Tierra del Fuego and Falkland Islands / Islas Malvinas by Calvelo & Liberatore (2002). The species is common in central parts of Torres del Paine National Park, more often on rocks than tree trunks. Specimens examined: CHILE. XII REGIÓN DE MAGALLANES: Parque Nacional Torres del Paine, 300 m E of Camping Pehoe, 51 ° 07’S, 73 ° 00’W, 80 m, on Nothofagus sp., 12 Mar 1998, Bjerke, J. W . 159/98 (TROM); 0.5 km NW of Guardería Laguna Amarga. 50 ° 59’S, 72 ° 47’W, 80 m, on cortex of Nothofagus antarctica in a SW facing slope near the river, 27 Nov 1996, Elvebakk, A . 96:521 (TROM); 500 m N of the western lake of Lagunas Mellizas, 51 ° 03’30”S, 72 ° 59’W, 100 m, very large specimens on rock surfaces in an open forest in a S-facing slope, 3 Dec 2000, Elvebakk, A . 00:900 (TROM); 00:904 (TROM); Pudeto, 300 m W of the northernmost inlet, 51 ° 04’S, 73 ° 01’W, 100 m, on a S-facing rock surface in Mulinum spinosum shrubland, 11 Dec 1999, Elvebakk, A . 99:1303 (TROM); Camping Pehoe, E side of Lago Pehoe, 51 ° 07’S, 73 ° 01’W, 70 m, on trunks of Nothofagus antarctica, 10 Mar 1998, Elvebakk, A . 98:459 & Bjerke, J. W. (TROM).Published as part of Elvebakk, A., Bjerke, J. W. & Støvern, L. E., 2014, Parmelioid lichens (Parmeliaceae) in southernmost South America, pp. 1-30 in Phytotaxa 173 (1) on page 11, DOI: 10.11646/phytotaxa.173.1.1, http://zenodo.org/record/514271
The 2012 Pilot Source Study (Phase III): Response to the Pilot Certification and Qualification Requirements for Air Carrier Operations
No full textThe 2012 Pilot Source Study (Phase III) was a continuation of the 2010 Pilot Source Study (Smith, Bjerke, NewMyer, Niemczyk & Hamilton, 2010), using the same research design with a new data set containing no duplicate records. University faculty and students assisted seven regional airlines to enter data on 4,024 pilots hired between 2005 and 2011. New-hire pilots’ college and piloting backgrounds defined their input (Source) variables. Training and first year operations data defined the output (Success) variables. Identifying information for pilots and participating airlines was removed fromthe data sets, and records were combined into a single data set for independent analysis by five researchers. Results were verified by two independent researchers from the University of Central Florida (a non-affiliated university). Results showed considerable consistency between the 2010 Pilot Source Study and the 2012 Pilot Source Study regarding initial pilot training at a regional air carrier. The study found that pilots entering the industry with an aviation-specific college degree, particularly a degree froman AABI-accredited flight program, performed better in initial training than those with no degree or a non-aviation degree. The results also indicated that a pilot’s background, such as having a CFI certificate and obtaining advanced training from a collegiate aviation program, is an indicator of success in training. One important result was that commercial pilots had more completions than pilots with an ATP certificate. On the other hand, total flight hours produced inconclusive results
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
No full textNucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. Human cells contain four distinct deoxyribonucleoside kinases that have partially overlapping substrate specificities for both naturally occurring deoxyribonucleosides as well as nucleoside analogs.The deoxycytidine analog 2 ,3-dideoxycytidine (ddC) has been used for treatment of human immunodeficiency virus (HIV) infections. ddC causes delayed toxicity, due to mitochondrial DNA (mtDNA) depletion, when cells are exposed to the drug at low concentration for prolonged periods of time. CEM T-lymphoblast cell lines resistant to the delayed toxicity of ddC were generated and studied. Although the cells were resistant to mtDNA depletion they had a retained anti-HIV activity of ddC. The ddC resistant cells were shown to have slightly increased levels of mtDNA and decreased mRNA expression of deoxycytidine kinase and thymidine kinase 2.Mitochondria are the main providers of energy for cells and these organelles have a separate genome distinct from the nuclear genome. The mitochondrial genome is dependent on the mitochondrial deoxyribonucleoside kinases for normal DNA replication. Inherited deficiency of either of the two mitochondrial deoxyribonucleoside kinases deoxyguanosine kinase (dGK) and thymidine kinase 2 (TK2), causes mtDNA depletion in patients. In order to understand the molecular mechanism of mtDNA depletion due to TK2 deficiency, a Tk2 deficient mouse strain was generated and characterized. The Tk2 deficient mice showed growth retardation, severe hypothermia and a reduced life span. They also exhibited mtDNA depletion in multiple organs. It was concluded that TK2 has a major role in supplying deoxyribonucleotides for mtDNA replication and that other pathways of deoxyribonucleotide synthesis cannot compensate for the loss of this enzyme.TK2 phosphorylates several nucleoside analogs that are also substrates of other deoxyribonucleoside kinases. To elucidate the role of TK2 mediated phosphorylation in the cytotoxic effects of nucleoside analogs, a human fibroblast cell line with partial TK2 deficiency was studied. A recombinant enzyme with the same mutation found in the TK2-deficient cells was also investigated in order to obtain further insights into the mechanisms of TK2 deficiency. It was concluded that the loss of TK2 activity did not alter the cells sensitivity to nucleoside analogs and that TK2 phosphorylation may be less important, compared to other deoxyribonucleoside kinases, for the cytotoxic effects of these compounds.The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside analogs. The broad substrate specificity together with the high catalytic rate makes it an interesting candidate gene for suicide gene therapy. In order to understand the determinants of the substrate specificity of the enzyme and to find Dm-dNK mutants with improved kinetic properties for application in suicide gene therapy, we performed site directed mutagenesis on the enzyme. It was shown that the mutants showed partial or complete loss of activity compared with the wild type enzyme in terms of thymidine phosphorylation. This decreased phosphorylation efficiency supports their importance for substrate binding.List of scientific papersI. Solaroli N, Bjerke M, Amiri MH, Johansson M, Karlsson A (2003). "Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase." Eur J Biochem 270(13): 2879-84 https://pubmed.ncbi.nlm.nih.gov/12823558II. Bjerke M, Franco M, Johansson M, Balzarini J, Karlsson A (2008). "Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2,3-dideoxycytidine." Biochem Pharmacol 75(6): 1313-21. Epub 2007 Dec 15 https://pubmed.ncbi.nlm.nih.gov/18206854III. Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A (2008). "Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice." Hum Mol Genet 17(15): 2329-35. Epub 2008 Apr 22 https://pubmed.ncbi.nlm.nih.gov/18434326IV. Bjerke M, Solaroli N, Lesko N, Balzarini J, Johansson M, Karlsson A (2008). "Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts" (Manuscript)</p
Hypotrachyna brevirhiza Hale 1975
No full textHypotrachyna brevirhiza (Kurok.) Hale (1975: 26) This species was described with its type (S) from Mina Elena at Isla Riesco, Magallanes (Hale & Kurokawa 1968). The species was described as common in southernmost South America, a conclusion confirmed by our studies. All studied specimens contain atranorin and salazinic acids (majors), and norstictic acid (minor). Specimens examined: ARGENTINA. PROVINCIA DE TIERRA DEL FUEGO: Río Irigoyen, Stenroos, S . 2715 (H; immixed with, and filed below Menegazzia magellanica). CHILE. XII REGIÓN DE MAGALLANES: Parque Nacional Torres del Paine, 2 km N of Salto Grande, 51 ° 04’S, 73 ° 01’W, 80 m, on S-facing rocks and on bases of Berberis microphylla, 7 Dec 2000, Elvebakk, A . 00:921 (TROM); Lago Pehoe NW, 500 m SE of Refugio y Camping Pehoe, 51 ° 04’30”S, 73 ° 07’W, 80 m, on a log in a river gorge, 6 Jan 1998, Elvebakk, A . 98:060 (TROM); Lago Pehoe E, at Camping Pehoe, 51 ° 07’S, 73 ° 01’W, on Nothofagus antarctica, Mar 1998, Elvebakk, A . 98:343 & Bjerke, J. W. (TROM); Puerto Natales, Cerro Dorotea, on sandstone rocks, 9 May 1940, Santesson, R . 8246a (S), Seno Skyring, N part, 3 km W of Puerto Altamirano, 52 ° 35’S, 72 ° 06’W, 30 m, on a fallen log of Nothofagus antarctica, 30 Nov 1999, Elvebakk, A . 99:979 (TROM); Península Brunswick, Punta Arenas W, Río de las Minas, 100 m, on Nothofagus pumilio, 12 Mar 1992, Elvebakk, A . 92:003; 21 Mar 1992, Elvebakk, A . 92:082 (TROM).Published as part of Elvebakk, A., Bjerke, J. W. & Støvern, L. E., 2014, Parmelioid lichens (Parmeliaceae) in southernmost South America, pp. 1-30 in Phytotaxa 173 (1) on page 7, DOI: 10.11646/phytotaxa.173.1.1, http://zenodo.org/record/514271
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
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