84 research outputs found
Supplementary_Table_1-4__Association_021019 – Supplemental material for Electroconvulsive therapy, depression severity and mortality: Data from the Danish National Patient Registry
No full textSupplemental material, Supplementary_Table_1-4__Association_021019 for Electroconvulsive therapy, depression severity and mortality: Data from the Danish National Patient Registry by Martin Balslev Jørgensen, Maarten Pieter Rozing, Charles H. Kellner and Merete Osler in Journal of Psychopharmacology</p
The effect of socioemotional wealth diversity within the top management team on earnings management in private family firms: The moderating role of the board of directors
No full textUsing a unique multiple-respondent dataset of 218 individual managers of 37 private family firms, this study examines differences in the importance attached to socioemotional wealth (SEW) preservation among top management team (TMT) members as a determinant of earnings management. Such SEW diversity might cause conflicts that can harm TMT decision-making quality and, ultimately, firm performance, which the TMT might cover up by engaging in earnings management. Furthermore, we examine to what extent a board of directors that functions as a sounding board is able to mitigate the relationship between SEW diversity within the TMT and earnings management.We thank the participants of the 2019 European Academy of Man-agement Conference held in Lisbon and the 2019 AccountingResearch Day held in Hasselt for their valuable comments.Corten, M (corresponding author), Hasselt Univ, Res Ctr Entrepreneurship & Family Firms RCEF, Martelarenlaan 42, B-3500 Hasselt, Belgium.
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CAY HILL: The possibilities of creating a synergy between an informal settlement, local craftmanship and cultural economic opportunities on Sint Maarten
No full textOn September 6th of 2017 Sint Maarten got struck by Hurricane Irma, which caused severe damage to the houses, especially to the informal settlements. Sint Maarten is a Caribbean island with a rooted past from its history that has caused severe economic difficulties. Along with, a high amount of migration that has been common among he islands, Sint Maarten has a tourism-led economy. In Turn, the hurricane also affected the tourism-led economy as many visits to the island declined. Lots of building materials on the island are getting imported. The island is lacking of local building resources and knowlegde. This project aims to propose an alternative housing solution and local economic business model for the people living in the informal settlement Cay Hill. This study is investigating the possibilities of creating a synergy between an informal settlement, local craftmanship and cultural economic opportunities on Sint Maarten.Architecture, Urbanism and Building Science
Profit (p)-index: the degree to which authors profit from co-authors.
No full textCurrent metrics for estimating a scientist's academic performance treat the author's publications as if these were solely attributable to the author. However, this approach ignores the substantive contributions of co-authors, leading to misjudgments about the individual's own scientific merits and consequently to misallocation of funding resources and academic positions. This problem is becoming the more urgent in the biomedical field where the number of collaborations is growing rapidly, making it increasingly harder to support the best scientists. Therefore, here we introduce a simple harmonic weighing algorithm for correcting citations and citation-based metrics such as the h-index for co-authorships. This weighing algorithm can account for both the nvumber of co-authors and the sequence of authors on a paper. We then derive a measure called the 'profit (p)-index', which estimates the contribution of co-authors to the work of a given author. By using samples of researchers from a renowned Dutch University hospital, Spinoza Prize laureates (the most prestigious Dutch science award), and Nobel Prize laureates in Physiology or Medicine, we show that the contribution of co-authors to the work of a particular author is generally substantial (i.e., about 80%) and that researchers' relative rankings change materially when adjusted for the contributions of co-authors. Interestingly, although the top University hospital researchers had the highest h-indices, this appeared to be due to their significantly higher p-indices. Importantly, the ranking completely reversed when using the profit adjusted h-indices, with the Nobel laureates having the highest, the Spinoza Prize laureates having an intermediate, and the top University hospital researchers having the lowest profit adjusted h-indices, respectively, suggesting that exceptional researchers are characterized by a relatively high degree of scientific independency/originality. The concepts and methods introduced here may thus provide a more fair impression of a scientist's autonomous academic performance
The relative contribution of co-authors.
No full text<p>Among the University Medical Centre researchers (n = 161), there was a non-significant trend for the association between the <i>p</i>-index and the <i>h</i>-index (ρ = +0.15, p = 0.067), while the <i>p<sub>h</sub>-</i>index and the <i>h</i>-index were only weakly associated (ρ = +0.17, p = 0.031), suggesting that the relative contribution of co-authors to the work of an author is relatively stable over his/her scientific career.</p
Altered cardiovascular risk pattern of LDL cholesterol in older adults
No full textPurpose of review Elevated serum low-density lipoprotein cholesterol (LDL-C) levels at middle-age constitute a strong risk factor for later cardiovascular events. In older populations, however, LDL-C levels are no longer predictive of cardiovascular mortality or may even seem protective. Whether the altered risk pattern of LDL-C in old age reflects a causal mechanism or is due to confounding and bias is subject to debate. In this review, we briefly discuss the possible explanations for the altered risk pattern of LDL-C observed in old age.Recent findings Using examples from the recent literature we illustrate how LDL-C levels ‘lose’ their predictive value as a cardiovascular risk factor in old age. We review three potential explanations for the changed cardiovascular risk pattern of LDL-C in older populations: survivorship bias, reverse causation, and effect modification.Summary The absent or protective effect of LDL-C on cardiovascular mortality in older populations found in observational studies might be explained by survivorship bias, reverse causation, and effect modification. However, this does not necessarily preclude the possibility that (specific) cholesterol-lowering treatment could decrease the risk of morbidity and mortality. Placebo-controlled trials may importantly add to our understanding of who may benefit from lipid-lowering therapy or statins at an older age.Purpose of reviewElevated serum low-density lipoprotein cholesterol (LDL-C) levels at middle-age constitute a strong risk factor for later cardiovascular events. In older populations, however, LDL-C levels are no longer predictive of cardiovascular mortality or may even seem protective. Whether the altered risk pattern of LDL-C in old age reflects a causal mechanism or is due to confounding and bias is subject to debate. In this review, we briefly discuss the possible explanations for the altered risk pattern of LDL-C observed in old age.Recent findingsUsing examples from the recent literature we illustrate how LDL-C levels 'lose' their predictive value as a cardiovascular risk factor in old age. We review three potential explanations for the changed cardiovascular risk pattern of LDL-C in older populations: survivorship bias, reverse causation, and effect modification.SummaryThe absent or protective effect of LDL-C on cardiovascular mortality in older populations found in observational studies might be explained by survivorship bias, reverse causation, and effect modification. However, this does not necessarily preclude the possibility that (specific) cholesterol-lowering treatment could decrease the risk of morbidity and mortality. Placebo-controlled trials may importantly add to our understanding of who may benefit from lipid-lowering therapy or statins at an older age. copy; </p
Electroconvulsive therapy and occupational functioning in individuals with major depression
No full textPurposeElectroconvulsive therapy (ECT) is a well-established treatment for severe depressive episodes, but its effect on subsequent occupational functioning remains unclear. This study examined labour market trajectories among individuals with major depression treated with ECT, compared to similar individuals with depression who did not receive ECT.MethodsThis population-based cohort study included all patients aged 15–55 with a first-time hospital contact for major depression (ICD-10 codes F32 and F33) in Denmark between 2000 and 2022. Patients treated with ECT were identified using the Danish National Patient Registry and matched 1:5 by age and sex to patients not treated with ECT. Labour market outcomes were assessed using data from the Danish Register for Evaluation of Marginalisation, tracking changes in employment and social transfer payments from one year before to three years after ECT/matching. Sequence analysis and Cox proportional hazards regression were used to evaluate time to regained employment, categorized as ≤6 months, 7–12 months, and 1–3 years.ResultsWe included 6672 ECT-treated patients and 27,940 matched non-ECT individuals. At baseline, ECT patients had lower employment rates (6.9 % vs. 39.5 %) but higher education and marriage rates. ECT was associated with slower return to work within 6 months (adjusted HR: 0.59, 95 % CI: 0.54–0.64), but similar or faster return at 7–12 months (HR: 1.12, 95 % CI: 1.01–1.24) and 1–3 years (HR: 1.05, 95 % CI: 0.96–1.14).ConclusionECT was linked to delayed short-term occupational recovery, but comparable or improved long-term return to work, supporting its continued use in treating major depression.Purpose Electroconvulsive therapy (ECT) is a well-established treatment for severe depressive episodes, but its effect on subsequent occupational functioning remains unclear. This study examined labour market trajectories among individuals with major depression treated with ECT, compared to similar individuals with depression who did not receive ECT. Methods This population-based cohort study included all patients aged 15–55 with a first-time hospital contact for major depression (ICD-10 codes F32 and F33) in Denmark between 2000 and 2022. Patients treated with ECT were identified using the Danish National Patient Registry and matched 1:5 by age and sex to patients not treated with ECT. Labour market outcomes were assessed using data from the Danish Register for Evaluation of Marginalisation, tracking changes in employment and social transfer payments from one year before to three years after ECT/matching. Sequence analysis and Cox proportional hazards regression were used to evaluate time to regained employment, categorized as ≤6 months, 7–12 months, and 1–3 years. Results We included 6672 ECT-treated patients and 27,940 matched non-ECT individuals. At baseline, ECT patients had lower employment rates (6.9 % vs. 39.5 %) but higher education and marriage rates. ECT was associated with slower return to work within 6 months (adjusted HR: 0.59, 95 % CI: 0.54–0.64), but similar or faster return at 7–12 months (HR: 1.12, 95 % CI: 1.01–1.24) and 1–3 years (HR: 1.05, 95 % CI: 0.96–1.14). Conclusion ECT was linked to delayed short-term occupational recovery, but comparable or improved long-term return to work, supporting its continued use in treating major depression.</p
Geotextile tubes filled with mine tailings as a construction element
No full textLarge quantities of mine tailings are stored in mine tailings storage facilities. These facilities are only costing money for mining companies. In addition, these tailings storage facilities are prone to failure. To prevent this from happening these facilities have to be reinforced. This research introduces a concept to use geotextile tubes filled with mine tailings as reinforcing construction elements. That way value is assigned to the mine tailings while also making the storage facilities safer. However, pumping mine tailings in geotextile tubes is not an option due to the small particle sizes which will flow through the openings in the geotextile fabric. In addition, the contaminations in the mine tailings will also be mobilised using this method. Therefore, this research investigates potential enhancement of mine tailings to make them suitable to be pumped in geotextile tubes. The potential enhancement is in the form of flocculation and remediation. While flocculation increases the dewatering properties of mine tailings, the remediation will prevent the contaminations from mobilising. Test performed in this research include a series of jar tests, cone tests, two different strength tests and hanging bag tests. The results show that when flocculants are added to the tailings, the dewatering rate increases. The flocculant type which proved the most effective for these specific tailings type is a flocculant with an average molecular weight and average anionic value. Adding coagulant to the tailings further increases the dewatering rate of the tailings. When Ordinary Portland Cement is added, to stabilise and solidify the tailings, the dewatering rate increases even more. In addition, adding Ordinary Portland Cement to the tailings resulted in an increase of shear strength and unconfined compressive strength. After seven days of curing, the highest strength of curing was measured for the mixtures where fifteen mass percentage Ordinary Portland Cement was added. The mixture where the highest strength and the fastest dewatering rate was measured, was the mixture composes of mine tailings, flocculants, coagulants and fifteen mass percentage Ordinary Portland Cement.With these results, it may be concluded that mine tailings can be used to fill geotextile tubes to form reinforcing construction elements if its dewatering behaviour is enhanced and its contaminants remediated
DotBot: Searching for a positive white cane experience
No full textThe design of the white cane, the most used mobility aid for visually impaired, has not changed significantly since the mid-20th century. New concepts and technological solutions have failed to catch on. However, the cane seems unappealing and outdated to some potential users. Margot Scheltema, the initiator of this graduation project, is a future cane user. She feels that the current cane design is alien from her identity and she feels reluctant to use it. She is not alone: due to the social stigma, many cane users feel self-conscious when using the device, some even decide not to use it, despite the mobility limitations resulting from such decision. Research After the initial desk research phase, field research was conducted to explore questions of VIP mobility. The process contributed to a high level of empathy for VIPs. Autoethnographic studies were conducted in collaboration with Thijs te Velde, to build a base of self-experience concerning VIP mobility struggles. Through the collaboration with Visio Den Haag and Margot Scheltema, different perspectives were represented in the research data. The most important mobility struggles and attitudes concerning mobility aids were identified. Positive aspects of VIP life and the inherent dilemmas were also collected. The design solution The Dot Bot is a navigation aid consisting of a network of location-specific navigational and environmental information nodes (Dots) accessible to a specific user group. The information is stored in the form of audio descriptions created by the userbase. This way virtual DotBot community facilitates the sharing of commuting know-how. The information Dots make use of existing VIP relevant infrastructural elements in the tactile paving. It is aimed to enhance the perks of being part of the VIP community, cultivating feelings of connectedness and belonging. The semantic qualities of the cane are preserved, to keep it recognisable and ensure user safety in commute. However, there are moments where the effects of impairment are preferred to keep private. For this reason, I aimed to limit the need to ask for directions and aid VIPs in cultivating pride and the feeling of competence through exercising their ability to navigate autonomously. The way the information is stored and accessed supports this: for the outsider eye accessing information from a road stud on the tactile paving is invisible. During the evaluation phase, several aspects of the DotBot concept were tested with VIP participants. In the first validation session, insights on information needs during navigation were collected. In the second validation session the envisioned interaction was evaluated by the help of functional prototypes, and feedback types were also investigated. Further studies would be needed to establish the optimal Dot density in vibrotactile feedback pattern and intensity.Integrated Product Desig
Primitiveren met elementaire functies
No full textIn dit bachelor eindproject kijken we naar de integreerbaarheid van eindige elementaire functies. Soms heb je het vermoeden dat een functie geen primitieve heeft in eindige termen, maar dan is dat vaak lastig om te bewijzen. Aan de hand van de stelling van Liouville-Rosenlicht gaan we in een aantal van zulke gevallen bewijzen dat de gevraagde primitieve niet bestaat. Je kunt er in dat proces ook achter komen dat de functie toch wel zo'n primitieve heeft. Dan krijg je met deze stelling vaak ook een aardig beeld van hoe de primitieve er ongeveer uit zou moeten zien. Voor het bewijzen van de stelling van Liouville-Rosenlicht duiken we een stuk de differentiaalalgebra in.Applied Mathematic
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