111,912 research outputs found

    Lasmiditan: an additional therapeutic option for the acute treatment of migraine

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    Introduction: Migraine is currently listed as the second cause of ‘years lived with disability’ and the sixth cause of global disability. Despite the burden associated to the disease, availability of specific drugs is still limited. Areas covered: The authors have evaluated lasmiditan, the first ‘ditan’ approved by the Food and Drugs Administration in 2019, from a global perspective: basic chemistry, pharmacodynamic and pharmacokinetic profiles, efficacy in migraine as a 5-HT1F receptor selective agonist, tolerability and clinical safety, and impact on migraine-related disability. Our evaluation considered original papers and review articles published from 2010 to 2020. Expert opinion: Available data point to the efficacy of lasmiditan in reducing migraine pain and the most bothersome symptoms within 2 hours from oral administration. Moreover, lasmiditan has a positive effect on migraine-related disability. Its side effects mostly reflect an involvement of the central nervous system or the vestibular system, while cardiovascular side effects are rare and mild. Lasmiditan can be safely prescribed in patients who have failed non-steroid anti-inflammatory drugs or triptans or with cardiovascular risk factors. Caution is advised in frequent users, due to lack of reliable data on its abuse potential. Further data are necessary to determine the usability of lasmiditan in particular populations, e.g. children and adolescents, pregnancy

    Effects of N fertilizers and rates on yield, safety and nutrients in processing spinach genotypes

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    Two field experiments were carried out at the Experimental Field, Department of Food Science (TE, Italy) in 2004 and 2005 to evaluate the effects of genotypes, different N forms and N rates on yield, safety and nutritional features of processing spinach. Experiment 1, as treatments, included spinach genotypes and N forms (CO(NH2)2; Agricote; NH4NO3); experiment 2 included three N forms (Ca(NO3)2; (NH4)2SO4; NH4NO3) applied at rates of 0, 75, 150, 200 kg N ha1. This research work confirmed differences among spinach genotypes in terms of efficiency in N use and oxalate and nitrate accumulation. Spinach accumulated much more nitrate in petioles and much more oxalate in blades indicating that nitrate and oxalate might play a counterrole to each other. Fertilizers containing N under forms not readily available to the crop, i.e. Agricote, CO(NH2)2 and (NH4)2SO4, increased nitrate and oxalate accumulations less than fast N-release fertilizers, but their effect on yield was limited. Highest yield with contents of nitrate and oxalate lower than the limits imposed to avoid health problems, were achieved with Ca(NO3)2, at rates of 130 and 150 kg N ha1 NH4NO3. A good accumulation in some important macronutrients for the human diet such as Ca, K and P were allowed by application of Ca(NO3)2, at rates of 130 and 150 kg N ha1 NH4NO3. The glucose, fructose, sucrose as well as Mg accumulation were not alterable in spinach with nitrogen fertilization or with genotype choice

    Attori Meridiani. Emancipazione e nuovi stili di vita dal Sud

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    La ricerca è partita dallo studio dei Gruppi di Acquisto Solidale in Terra di Bari e in Puglia scegliendo di partire dal Sud per conoscere le realtà esistenti senza necessariamente paragonarle a quelle del Nord Italia. Ciò ha consentito uno sguardo più libero da definizioni normative precostituite. Gli intervistati sono stati coinvolti in fase di avvio della ricerca invitandoli ad un workshop ad Altamura durante il Festival dei Claustri, poi in Università nell’iniziativa Cartografie sostenibili. Nuovi stili di vita e integrazione dei soggetti deboli, aprendo una sorta di tavolo di confronto fra soggetti molto diversi, e realizzando insieme un ciclo di seminari contro lo spreco. Il ‘racconto dei racconti’ è confluito poi in una iniziativa nazionale di ricognizione degli esperimenti di economia trasformativa organizzata da Comune-info a Roma. I soggetti coinvolti nella ricerca rappresentano un tentativo di emanciparsi dallo sfruttamento legato all’acquisto e alla produzione nel sistema capitalistico che è connesso a sfruttamento intensivo della terra e dei lavoratori, quindi, parte dal metodo (la scelta di partire dal Sud dando voce a soggetti marginali) e dallo sguardo con cui il ricercatore si relaziona a un mondo che non conosce e da cui talvolta è interrogato. La ricerca è stata una ricerca conoscitiva ma i soggetti incontrati hanno mostrato caratteri di impegno politico e lotta per il riconoscimento delle proprie specificità che ha portato ad una loro descrizione come ‘attori meridiani’

    author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct

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    Supplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
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